A Review Article on Implications of Prenatal Folic Acid Supplements on the Risk of Autism Spectrum Disorder (ASD )in Offspring
Article Sidebar
Main Article Content
Page: 575-585
Abstract
Folic acid plays an important role for the health of mothers and babies, especially in the growth and development of the fetus. Based on several previous studies, it was found that prenatal folic acid deficiency or excess can increase the risk of Autism Spectrum Disease (ASD) in infants. This raises concerns about the adverse effects of prenatal folic acid supplements including an increased risk of ASD. Therefore, this literature review article was created to further explore the implications or involvement of maternal folic acid supplementation on the risk of ASD in their offspring. The Google Scholar, Pubmed, and Connected Papers electronic databases were used to find literature that met the criteria. The results of this review found a potential beneficial effect of prenatal folic acid supplementation on the risk of developing ASD, although conflicting results have been reported. In summary, this literature review article demonstrates that prenatal folic acid supplementation can significantly reduce the risk of ASD in offspring compared to women without prenatal folic acid supplementation.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
References
Adams, J. B., Audhya, T., Geis, E., Gehn, E., Fimbres, V., Pollard, E. L., Mitchell, J., Ingram, J., Hellmers, R., Laake, D., Matthews, J. S., Li, K., Naviaux, J. C., Naviaux, R. K., Adams, R. L., Coleman, D. M., & Quig, D. W. (2018). Comprehensive nutritional and dietary intervention for autism spectrum disorder—a randomized, controlled 12-month trial. Nutrients, 10(3), 1–43. https://doi.org/10.3390/nu10030369
American Psychiatric Association. (2013). DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS FIFTH EDITION (DSM-5) (5th ed). American Psychiatric Association.
Braun, J. M., Froehlich, T., Kalkbrenner, A., Pfeiffer, C. M., Fazili, Z., Yolton, K., & Lanphear, B. P. (2014). Are autistic-behaviors in children related to prenatal vitamin use and maternal whole blood folate concentrations? NIH Public Acces, 44(10), 2602–2607. https://doi.org/10.1212/WNL.0000000000003475
Brieger, K., Bakulski, K., Pearce, C., Baylin, A., Dou, J., Feinberg, J., Croen, L., Hertz-Picciotto, I., Newschaffer, C., Fallin, M., & Schmidt, R. (2021). The Association of Prenatal Vitamins and Folic Acid Supplement Intake with Odds of Autism Spectrum Disorder in a High-Risk Sibling Cohort, the Early Autism Risk Longitudinal Investigation (EARLI). https://doi.org/10.1007/s10803-021-05110-9
CDC (Centers for Disease Control and Prevention). (2021). Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network , 11 Sites , United States , 2018. Surveillance Summaries, 70(11).
DeVilbiss, E., Magnusson, C., Gardner, R., Rai, D., Newschaffer, C., Lyall, K., Dalman, C., & Lee, B. K. (2017). Antenatal nutritional supplementation and autism spectrum disorders in the Stockholm youth cohort: population based cohort study. https://doi.org/10.1136/bmj.j4273
Guo, M., Li, L., Zhang, Q., Chen, L., Dai, Y., Liu, L., Feng, J., Cai, X., Cheng, Q., Chen, J., Wei, H., & Li, T. (2020). Vitamin and mineral status of children with autism spectrum disorder in Hainan Province of China: associations with symptoms. Nutritional Neuroscience, 23(10), 803–810. https://doi.org/10.1080/1028415X.2018.1558762
Hernawan, A. D., Diningrum, A., Jati, S. N., & Nasip, M. (2018). Risk Factors of Autism Spectrum Disorder (ASD). Unnes Journal of Public Health, 7(2), 104–112.
Hoxha, B., Hoxha, M., Domi, E., Gervasoni, J., Persichilli, S., Malaj, V., & Zappacosta, B. (2021). Folic Acid and Autism: A Systematic Review of the Current State of Knowledge. https://doi.org/10.3390/cells10081976
Huang, X., Ye, Y., Li, Y., Zhang, Y., Zhang, Y., Jiang, Y., Chen, X., Wang, L., & Yan, W. (2020). Maternal folate levels during pregnancy and children’s neuropsychological development at 2 years of age. European Journal of Clinical Nutrition, 74(11), 1585–1593. https://doi.org/10.1038/s41430-020-0612-9
Levine, S., Kodesh, A., Viktorin, A., Smith, L., Uher, R., Reichenberg, A., & Sandin, S. (2018). Association of Maternal Use of Folic Acid and Multivitamin Supplements in the Periods Before and During Pregnancy With the Risk of Autism Spectrum Disorder in Offspring. JAMA Psychiatry. https://doi.org/10.1001/jamapsychiatry.2017.4050
Li, Q., Yang, T., Chen, L., Dai, Y., Wu, L. J., Jia, F. Y., Hao, Y., Li, L., Zhang, J., Ke, X. Y., Yi, M. J., Hong, Q., Chen, J. J., Fang, S. F., Wang, Y. C., Wang, Q., Jin, C. H., Dong, Z. F., Chen, J., & Li, T. Y. (2021). Serum Folate Status Is Primarily Associated With Neurodevelopment in Children With Autism Spectrum Disorders Aged Three and Under—A Multi-Center Study in China. Frontiers in Nutrition, 8(May), 1–11. https://doi.org/10.3389/fnut.2021.661223
Lord, C., Elsabbagh, M., Baird, G., & Veenstra-vanderweele, J. (2018). Autism spectrum disorder. The Lancet, 6736(18), 1–13. https://doi.org/10.1016/S0140-6736(18)31129-2
Orabona, R., Zanardini, C., Zatti, S., Sartori, E., & Prefumo, F. (2020). Folic Acid Supplementation in Pregnancy: A Matter of Doses? Hypertension, 76, 30–31. https://doi.org/10.1161/HYPERTENSIONAHA.120.15009
Raghavan, R., Fallin, M. D., & Wang, X. (2016). Maternal plasma folate, vitamin B12 levels and multivitamin supplementation during pregnancy and risk of Autism Spectrum Disorder in the Boston Birth Cohort. The FASEB Journal, 30, 151-6.
Raghavan, R., Riley, A. W., Volk, H., Caruso, D., Hironaka, L., Sices, L., Hong, X., Wang, G., Ji, Y., Brucato, M., Wahl, A., Stivers, T., Pearson, C., Zuckerman, B., Stuart, E. A., Landa, R., Fallin, M. D., & Wang, X. (2018). Maternal Multivitamin Intake, Plasma Folate and Vitamin B12 Levels and Autism Spectrum Disorder Risk in Offspring. Paediatric and Perinatal Epidemiology, 32(1), 100–111. https://doi.org/10.1111/ppe.12414
Salari, N., Rasoulpoor, S., Rasoulpoor, S., Shohaimi, S., Jafarpour, S., & Abdoli, N. (2022). The global prevalence of autism spectrum disorder : a comprehensive systematic review and meta ‑ analysis. Italian Journal of Pediatrics. https://doi.org/10.1186/s13052-022-01310-w
Sampaio, A. C., Neto, F. F. de M., Lopes, L. de L., Marques, Í. M. M., Tavares, R. M., Fernandes, M. V. de M., Teixeira, M. R. V. da S., de Brito, A. B., Feitosa, A. C., Guedes, T. O., & Mota, M. L. (2021). Association of the Maternal Folic Acid Supplementation with the Autism Spectrum Disorder : A Systematic Review. Rev Bras Ginecol Obstet, 43(10), 775–781. https://doi.org/ 10.1055/s-0041-1736298
Schmidt, R., Iosif, A., Angel, E. G., & Ozonoff, S. (2019). Association of Maternal Prenatal Vitamin Use With Risk for Autism Spectrum Disorder Recurrence in Young Siblings. https://doi.org/10.1001/jamapsychiatry.2018.3901
Shoffner, J., Trommer, B., Thurm, A., Farmer, C., Langley III, W. A., Soskey, L., Rodriguez, A. N., D’Souza, P., Spencer, S. J., Hyland, K., & Swedo, S. E. (2016). Author response: CSF concentrations of 5-methyltetrahydrofolate in a cohort of young children with autism. American Academy of Neurology, 86, 1–7. https://doi.org/10.1212/WNL.0000000000003475
Steenweg-de Graaff, J., Ghassabian, A., Jaddoe, V. W. V., Tiemeier, H., & Roza, S. J. (2014). Folate concentrations during pregnancy and autistic traits in the offspring. the Generation R Study. European Journal of Public Health, 25(3), 431–433. https://doi.org/10.1093/eurpub/cku126
Sudargo, Toto., Aristasari, Tita., 'Afifah, Aulia. (2018). 100 Hari Pertama Kehidupan. Yogyakarta: Gadjah Mada University Press.
Sun, C., Zou, M., Zhao, D., Xia, W., & Wu, L. (2016). Efficacy of folic acid supplementation in autistic children participating in structured teaching: An open-label trial. Nutrients, 8(6), 1–14. https://doi.org/10.3390/nu8060337
Swaroopa, M. M., Saranya, P., Premika, S. S., & Varsha, C. S. (2020). The impact of folic acid supplementation on pregnancy. 9(5), 778–783.
Tan, M., Yang, T., Zhu, J., Li, Q., Lai, X., Li, Y., Tang, T., Chen, J., & Li, T. (2019). Maternal folic acid and micronutrient supplementation is associated with vitamin levels and symptoms in children with autism spectrum disorders. Reproductive Toxicology. https://doi.org/10.1016/j.reprotox.2019.11.009
USPSTF (US Preventive Services Task Force). (2017). Folic Acid Supplementation for the Prevention of Neural Tube Defects. JAMA - Journal of the American Medical Association, 317(2), 183–189. https://doi.org/10.1001/jama.2016.19438
Valentin, M., Coste, P., Zerah, M., Franc, P., Benachi, A., & Luton, D. (2017). Acid folic and pregnancy : A mandatory supplementation. Ann Endocrinol. https://doi.org/10.1016/j.ando.2017.10.001
Vázquez, L. I., Canals, J., & Arija, V. (2019). Review and meta-analysis found that prenatal folic acid was associated with a 58% reduction in autism but had no effect on mental and motor development. Acta Paediatrica, International Journal of Paediatrics, 108(4), 600–610. https://doi.org/10.1111/apa.14657
Virk, J., Liew, Z., Olsen, J., Nøhr, E., Catov, J., & Ritz, B. (2015). Preconceptional and prenatal supplementary folic acid and multivitamin intake and autism spectrum disorders. Autism, 1–9. https://doi.org/10.1177/1362361315604076
World Health Organization. (2016). Guideline: WHO Recommendations on Antenatal Care for a Positive Pregnancy Experience. Geneva, Switzerland: World Health Organization.
World Health Organization. (2019). Periconceptional folic acid supplementation to prevent neural tube defects. e-Library of Evidence for Nutrition Actions (eLENA). Diakses pada Oktober 31, 2022, dari https://www.who.int/elena/titles/folate_periconceptional/en/
Zeidan, J., Fombonne, E., Scorah, J., Ibrahim, A., Durkin, M. S., Saxena, S., Yusuf, A., Shih, A., & Elsabbagh, M. (2022). Global prevalence of autism : A systematic review update Search strategy. 15(February), 778–790. https://doi.org/10.1002/aur.2696