Journal of Pharmaceutical and Sciences 2024-02-21T11:54:17+00:00 Salman Open Journal Systems <p>Thank you for visiting the Journal of Pharmaceutical and Sciences (e-ISSN: 2656-3088). It is with great pleasure that the first issue of the JJournal of Pharmaceutical and Sciences is released to the academic world, which is intended to accommodate the needs of researchers to publish their work. The Faculty of Pharmacy at Tjut Nyak Dhien University publishes this journal. This journal's publisher is dedicated to advancing research and knowledge in the pharmaceutical, science, and health fields. Articles that have been published can be accessed and downloaded online by the public (open-access journal). Manuscripts can be submitted to the Journal of Pharmaceutical and Sciences in Indonesian and English. The Journal of Pharmaceutical and Life Sciences has been accredited by the Directorate General of Higher Education, Ministry of Research, Technology, and Higher Education, Republic of Indonesia. With a SINTA accreditation rating of 4. Certificate No. 164/E/KPT/2021 (<a href="">download Certificate</a>).</p> <p><strong>Journal Migration</strong></p> <p>As of January 1, 2023, Volume 6 number 1, the Journal of Pharmaceutical and Sciences has migrated to a new website at <a href=""></a>. While the old version (volume 1 to volume 5) can still be accessed as usual at the URL: <a href=""></a> or <a href=""></a>.</p> <p><a href=""><strong>Submit your manuscript via the new website</strong></a></p> Effect of ball milling on ibuprofen solid dispersion with HPMC carrier on particle size and capsule dissolution rate 2024-02-13T18:32:56+00:00 Nining Nining Inding Gusmayadi Febri Romansyah <p>One factor that greatly influences the active drug solubility is particle size. Ibuprofen is a non-steroidal anti-inflammatory that is poorly water-soluble, potentially slowing its drug dissolution. Milling is one way to reduce particle size and help to enhance drug dissolution. This research aims to study the milling process effect on the particle size of ibuprofen and the capsule dissolution rate. Micrometer-sized ibuprofen (P1) is processed to nanometer size using the wet-milling method for 15 hours (P2) and 20 hours (P3) using HPMC (Hydroxy Propyl Methyl Cellulose) as a stabilising polymer. All particles were evaluated for particle size, and FTIR was tested and formulated into capsules. The powder mass was evaluated for flow properties. Capsule evaluation was also carried out, which included a disintegration time test, weight uniformity test, and dissolution test. The three particles have sizes of 40.6 µm (P1), 438.9 ± 20.9 nm (P2), and 267.1 ± 4.1 nm (P3). FTIR test results show compatibility between ibuprofen and HPMC. The disintegration time test results and capsule weight uniformity met the compendial requirements. Based on the dissolution test, the three formulas showed significant differences (sig p 0.0002 &lt; 0.05) in the per cent dissolution. Obtained Q60 F1-F3 respectively were 99.61 ± 8.75%; 110.03±5.97%; and 115.95 ± 3.34%. The conclusion obtained is that the milling process has a significant effect on the dissolution percentage of ibuprofen<strong>.</strong></p> 2024-02-15T00:00:00+00:00 Copyright (c) 2024 Nining Nining, Inding Gusmayadi, Febri Romansyah Associated effective communication on outpatient registration officers with patient satisfaction at Adven Hospital Medan 2024-02-18T16:49:22+00:00 Dyna Safitri Rakhelmi Rangkuti Andini Mentari Tarigan Panjaitan Hanyita Rachelia <p><em>Effective communication is conveying thoughts or information from one person to another so that others grasp what the information provider means. Effective communication is required while working with patients; if it is not used effectively, it will disrupt the connection, resulting in patient discontent. This study aimed to investigate the effectiveness of outpatient registration officers' communication associated with patient satisfaction at&nbsp; Advent Hospital Medan 2023.</em> <em>The research method was quantitative, using a cross-sectional approach. The population consisted of all outpatients registered at the Outpatient Patient Registration, including 28,963 respondents. Purposive sampling was utilized in this investigation, with a total sample of 100 respondents. The Chi-Square test used univariate and bivariate data analyses</em><em>. </em><em>The results showed that the respect variable had a p-value value of 0,000 &lt;0.05, the empathy variable had a p-value value of 0,000 &lt;0,05, the audible variable had a p-value value of 0.000 &lt;0.05, the clarity variable had a p-value value 0,000 &lt;0.05 and the Humble variable has a P-value value of 0,000 &lt;0.05</em><em>. </em><em>According to the findings of this study, respect, empathy, audibility, lucidity, and humble outpatient registration officers are associated with patient happiness. The registration officer advised to develop effective contact with patients to promote patient satisfaction with health services.</em></p> 2024-02-18T00:00:00+00:00 Copyright (c) 2024 Dyna Safitri Rakhelmi Rangkuti, Andini Mentari Tarigan, Panjaitan Hanyita Rachelia Anatomical Therapeutic Chemical / Define Daily Dose for evaluation of bronchopneumonia pediatric antibiotics use at Roemani Muhammadiyah Hospital 2024-01-08T14:59:26+00:00 Rissa Maharani Dewi Nanda Maprillia Nindita Sari Nastiti <p>The increase in repeat hospitalizations after the covid19 pandemic with bronchopneumonia diagnoses in pediatric patients is the first rank. Therapeutic management was associated with the length of hospitalization. Pediatric bronchopneumonia is the case with antibiotic therapy. Current guidelines recommend first-line and alternative options in the management of antibiotic therapy for pneumonia in hospitalized pediatric patients. Empirical broad-spectrum antibiotic therapy for acute infections with consideration of the common etiology of possible pneumococcal involvement The risk of resistance increases with the massive use of antibiotics. The study had an observational descriptive design with retrospective data collection from 280 samples of pediatric patients, aiming to evaluate the use of antibiotics with the ATC/DDD method. Based on empirical selected therapy DDD (Define Daily Dose)/100 patient days, the quantity of antibiotics that are widely used is ceftriaxon 38.36 DDD /100 patient days followed by Cefoperazon sulbactam 3.88 DDD /100 patient days, Cefotaxime 3.77 DDD /100 patient days, Gentamicin 2.57 DDD /100 patient days, Amikacin 1. 70 DDD /100 patient days, Azithromycin 0.76 DDD /100 patient days, Ampicillin Sulbactam 0.50 DDD /100 patient days, Cefixime 0.27 DDD /100 patient days, and Meropenem 0.13 DDD /100 patient days. Drug data included in DU90% are Ceftriaxon, Cefoperzon Sulbactam, Cefotaxime. From the research conducted, the highest DDD/100 patient days value was Ceftriaxon. DDD value indicates high use of antibiotics, does not mean unreasonable use of drugs, so a qualitative review must be done<strong>.</strong></p> 2024-02-22T00:00:00+00:00 Copyright (c) 2024 Rissa Maharani Dewi , Nanda Maprillia , Nindita Sari Nastiti The effect of concentration variation on the physical properties and stability tests of freeze-thaw cycling on gel formula for the combination of moringa leaf extract and lime leaf extract 2024-02-20T13:52:25+00:00 Intan Juliana Annisa Fatmawati Muhammad Abdurrahman Munir Emelda Emelda Feti Rahmawati <p><em>Moringa leaves are a major source of antioxidant compounds due to their high content in carotenoids, ascorbic acid, glucosinolates and other bioactives. Lime contains elements of useful chemical compounds, such as alkaloids, polysaccharides, flavonoids, and essential oils. This study aims to obtain a gel formula that is physically stable and stable during storage using the Freeze-Thaw Cycling method from Moringa leaf extract and lime leaf extract. This research is a laboratory experimental research. Gel preparation was carried out with varying concentrations of Moringa leaf extract and lime leaf extract F1 (75%:25%), F2 (50%:50%), and F3 (25%:75%). Testing the physical properties of the gel includes organoleptic, pH, homogeneity, viscosity, spreadability, adhesion and syneresis. The stability test carried out was a stability test using the Freeze-Thaw Cycling method for 3 cycles by observing the stability to be carried out where each cycle observed physical changes in the gel including organoleptic, homogeneity and pH. The results of gel preparations of the combination of ethanol extract of moringa leaves and lime leaves of formulations 1, 2, and 3 with differences in the concentration of the active substance were declared stable, because there was no significant change from organoleptic observations, homogeneity, pH, adhesion and spreadability. However, statistical tests stated that the 4</em><em>℃</em><em> temperature adhesion test obtained a p value (&lt;0.05) and a 40</em><em>℃</em><em> temperature p value (&gt;0.05), while the 4</em><em>℃</em><em> and 40</em><em>℃</em><em> temperature spreadability test obtained a p value (&lt;0. 05)</em><strong>.</strong></p> 2024-02-22T00:00:00+00:00 Copyright (c) 2024 Intan Juliana, Annisa Fatmawati, Muhammad Abdurrahman Munir, Emelda, Feti Rahmawati Acute toxicity test of rattan cell extract (Daemonorop melanochaetes Bl.) on shrimp larva (Artemia Salina Leach) using the brine shrimp lethality test (BSLT) method 2024-02-21T11:54:17+00:00 Athaillah Athaillah Roqayyah Maulida Lubis Putra Chandra Aswan Pangondian Robiatun Rambe <p>Cell rattan is very popular because it has properties in treating malaria, diabetes and also has appetite-stimulating properties. The chemical content of rattan consists of flavonoids, alcohol, triterpenoids, saponins and glycosides. Flavonoids consist of 15 carbon atoms with a C6-C3-C6 structure. In plants, flavonoids are bound to sugars in the form of flavonoid glycosides and aglycones. Research methods include making rattan extract using the maceration method, phytochemical screening, toxicity activity testing using the BSLT (Brine Shrimp Lethality Test) method and determining the LC<sub>50</sub> value based on the probit value. The research results show that rattan extract contains secondary metabolite compounds, including steroids/triterpenoids, saponins, flavonoids, glycosides and alkaloids. The results of the toxicity activity test showed that the LC<sub>50</sub> value was 322 ppm and was included in the toxic category.</p> 2024-02-22T00:00:00+00:00 Copyright (c) 2024 Athaillah, Roqayyah Maulida Lubis, Putra Chandra, Aswan Pangondian, Robiatun Rambe Lifestyle description of hypertensive patients in the Pamolokan health center of Sumenep city district of Sumenep regency in 2023 2024-01-27T01:17:24+00:00 Nadiyah Ulfa Henry Purbowo Sintoro Prajogo Wibowo Ronald Pratama A. <p>Hypertension, a widespread global health issue, significantly contributes to the burden of non-communicable diseases. Its escalating prevalence globally and in Indonesia necessitates a comprehensive understanding of associated lifestyle patterns. This study, conducted at Pamolokan Health Center in Sumenep City District, Sumenep Regency, in 2023, focuses on the lifestyles of hypertensive patients. Globally, hypertension affects a substantial portion of the population, impacting public health significantly. In Indonesia, the prevalence of hypertension has steadily risen, prompting a focused examination of contributing factors. Among 85 hypertensive respondents, those aged 36-45 comprised 74.12%, with females constituting 76.67%. Hypertension severity varied, with 55.29% experiencing grade 1 hypertension. The study assessed lifestyle components, revealing 23.53% smoking, 67.06% favouring salty foods, 52.94% consuming fatty foods, 58.82% indulging in coffee, and 35.29% reporting regular physical activity. Understanding the lifestyle patterns of hypertensive patients is crucial for devising targeted interventions. This study's findings illuminate the interplay between age, gender, hypertension severity, and lifestyle choices. Insights contribute to the hypertension management and prevention discourse, emphasising the imperative of tailored public health strategies to address this global health challenge<strong>.</strong></p> 2024-03-02T00:00:00+00:00 Copyright (c) 2024 Nadiyah Ulfa, Henry Purbowo Sintoro, Prajogo Wibowo, Ronald Pratama Adiwinoto The role of pharmacists in handling self-medication minor illness cases at the pharmacy 2024-02-01T13:21:17+00:00 Yasmin Ramadania Burhanudin Dolih Gozali <p>Health is a crucial part of life. An individual's level of living is reflected in their state of health. The most important thing to do if the person has health issues at any point is to make every effort to heal through self-medication. Preparing this article is to evaluate how healthy pharmacists perform self-medication and make drug selections to enhance public health. Self-medication is typically used to cure common minor health issues, such as skin infections, worm infections, coughs, influenza, stomach ulcers, dizziness, coughing, diarrhea, and coughing up blood. The research in question was derived from search engine results and examined pharmacists' capacity to prescribe medications for mild ailments. According to the search results in several journals, the overall accuracy rate of recommendations for children experiencing acute diarrhea is 13.09%; for diarrhea, including blood, it is 34.52%; for dyspepsia due to side effects of Diclofenac Sodium, it is 21%; and for dyspepsia without alarm, symptoms is 83%. According to research findings, enhancing pharmacists' capacity to offer drug guidance while facilitating self-medication is crucial<strong>.</strong></p> 2024-03-03T00:00:00+00:00 Copyright (c) 2024 Yasmin Ramadania Burhanudin, Dolih Gozali