Review of the Analysis of the Effectiveness and Risk of Aminophylline Toxicity in the Treatment of Asthma
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Abstract
Asthma is a chronic inflammatory disease of the airways that involves many cells and factors. Physiologically, asthma is characterized by narrowing of the airways that causes increased hypersensitivity which is characterized by repeated episodic symptoms of wheezing, shortness of breath, chest tightness, and coughing, especially at night and or in the morning. The World Health Organization (WHO) estimates that the number of asthmatic diseases in 2019 is around 235 million. Asthma is a worldwide health problem, affecting approximately 1-18% of the population in various countries around the world. Aminophylline is the most common asthma drug used to treat asthma in Indonesia and is a drug with a narrow therapeutic range with a high risk of adverse drug reaction (ADR). Improper use of aminophylline will cause many side effects that can potentially be fatal and can actually make a person experience medical problems due to side effects that are more severe than the main medical problem. The purpose of this review article is to analyze the effectiveness and risk of aminophylline in the treatment of asthma using a literature study method taken from various international and national journals. Based on the results of the literature study, it was found that aminophylline in its use produces a toxic effect that is greater than its effectiveness.
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References
Amelia L, Endang W, Supriadi. Keamanan Penggunaan Aminofilin pada Pengobatan Asma di Rumah Sakit Delta Surya Sidoarjo. Jurnal Farmasi Klinik Indonesia. Universitas Surabaya, Surabaya, Indonesia. Volume 1, Nomor 4.
Aralihond A, Shanta Z, Pullattayil A, et al. Treating acute severe asthma attacks in children: using aminophylline. Breathe 2020; 16: 200081.
Bereda G. Bronchial Asthma: Etiology, Pathophysiology, Diagnosis and Management. Austin J Pulm Respir Med. 2022; 9(1): 1085.
Dalabih AR, et al., Aminophylline infusion for status asthmaticus in the pediatric critical care unit setting is independently associated with increased length of stay and time for symptom improvement, Pulmonary Pharmacology & Therapeutics (2013), http://dx.doi.org/10.1016/j.pupt.2013.03.001
Dian A., Miyati, Hasty M. (2021). Pengaruh Kombinasi Teofilin Dan Ekstrak BawangPutih (Allium sativum) Terhadap Diameter Lumen Bronkiolus Mencit Asma. Jurnal Farmasi Indonesia.
Farida, F., Retnosari, A., & Maksum, R. (2020). Quality of Antibiotic Prescribing for Respiratory Tract Disease in Primary Healthcare Centers in Tegal Regency, Central Java, Indonesia. Indonesian Journal of Clinical Pharmacy, 9(2), 95-104.
Jocelyn SA. ElliottShannon DS. Parents' self-reported experiences and information needs related to acute pediatric asthma exacerbations: A mixed studies systematic review. Edmonton Clinic Health Academy, University of Alberta, Canada.PEC Innovation 1 (2022) 100006.
Leung JS. Paediatrics: how to manage acute asthma exacerbations. Drugs in Context 2021; 10: 2020-12-7. DOI: 10.7573/dic.2020-12-7.
Lorensia, A. (2020). Study of Cost-Consequences Analysis Between Salbutamol With Aminophyllin For Exacerbation Asthma. KELUWIH: Jurnal Kesehatan dan Kedokteran, 1(2), 60-66.
Lorensia, A., Ikawati, Z., Andayani, T. M., Suryadinata, R. V., Hantoro, K. A., & Firanita, L. D. (2018). Efektivitas dan risiko toksisitas aminofilin intravena pada pengobatan awal serangan asma. Jurnal Farmasi Klinik Indonesia, 7(2), 78-88.
Lutfiyati, H., Ikawati, Z., & Wiedyaningsih, C. (2015). Efek Samping Penggunaan Terapi Oral Pada Pasien Asma. Jurnal Farmasi Sains dan Praktis, 1(1), 21-28.
Neame M, Aragon O, Fernandes RM, et al. Arch Dis Child Educ Pract Ed 2015;100:215–222.
Soleimani Gh, Shafighi Shahri E, Soleimanzadeh MSH. Acute Bronchiolitis Treatment: A Comparison of Montelukast, Aminophylline and Ventolin in Pediatric Patients: A Clinical Trial Study. Int J Pediatr 2021; 9(6): 13683-690. DOI: 10.22038/IJP.2020.51086.4055.
Suryoputri, M. W., Mustikaningtias, I., & Maharani, L. (2020). Pemantauan kadar obat indeks terapi sempit melalui estimasi kadar obat di dalam darah pada pasien rawat inap di RSUD Prof. Dr. Margono Soekardjo, Purwokerto. Indones J Clin Pharm, 9(2), 105-17.
Tiwari A, Guglani V, Jat KR. Ketamine versus aminophylline for acute asthma in children: A randomized, controlled trial. Ann Thorac Med 2016;11:283-8.