Review artikel: Metode Analisis obat Tuberkulosis Dalam Plasma Darah
Bilah Samping Artikel
Isi Artikel Utama
Page: 848-862
Abstrak
Penyakit tuberkulosis merupakan suatu gangguan pernapasan yang menular dan penyebabnya dari adanya infeksi bakteri Mycobacterium Tuberkulosis (bakteri aerob). Pengobatan tuberculosis biasa digunakan obat lini pertama yakni isoniazid, rifampisin, etambutol dan pirazinamid. Tujuan penelitian ini adalah untuk meninjau efektivitas dari pengembangan metode HPLC atau UPLC dengan detektor UV dan MS untuk meninjau konsentrasi obat tuberkulosis dalam sampel biologis plasma darah. Metode pencarian penulis dalam menyusun hasil review jurnal mengenai pengembangan metode analisis obat anti tuberkulosis (OAT) dalam sampel biologis darah dengan menggunakan database dari Google Scholar dan Pubmed®. Sejumlah 26 jurnal yang relevan akan digunakan untuk pembahasan dalam review jurnal. Hasil yang diperoleh adalah metode yang paling banyak digunakan dalam analisis OAT dengan menggunakan HPLC/UPLC detektor massa dan ultaviolet dalam suatu sampel biologis, plasma darah. Dilaporkan dalam beberapa penelitian bahwa metode UPLC terjadi peningkatan sensitivitas yang ditunjukkan dengan adanya penurunan nilai LOD dan LOQ dibandingkan dengan metode HPLC.
Unduhan
Rincian Artikel
Artikel ini berlisensiCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Referensi
Akash, M. S. H., & Rehman, K. (2019). Essentials of pharmaceutical analysis. In Essentials of Pharmaceutical Analysis. https://doi.org-/10.1007/978-981-15-1547-7
Annissa. S., Musfiroh. I., Indriati. L. (2020). Metode Analisis Instrumen HPLC dan UHPLC : Artikel Review. Farmaka. Vol 17(3).
Aprilia, F. R., Ayuliansari, Y., Putri, T., Azis, M. Y., Camelina, W. D., & Putra, M. R. (2018). Analisis Kandungan Kafein Dalam Kopi Tradisional Gayo Dan Kopi Lombok Menggunakan Hplc Dan Spektrofotometri Uv/Vis. BIOTIKA Jurnal Ilmiah Biologi, 16(2), 40. https://doi.org/10.24198/bjib.v16i-2.19829
Arbianto, A. D., Rahayu, M. D., Kusumaningrum, S., Azhar, R., & Jannah, R. (2020). Pengembangan dan Validasi Metode High Performance Chromatography (HPLC) untuk Analisis Sodium Seftriakson. Pertemuan Dan Presentasi Ilmiah Standardisasi, 2019, 91–98. https://doi.org/-10.31153/ppis.2019.10
Aviana, F., Jati, S. P., & Budiyanti, R. T. (2021). Systematic Review Pelaksanaan Programmatic Management of Drug-Resistant Tuberculosis Pada Pasien Tuberkulosis Resistan Obat. Jurnal Kesehatan Masyarakat (Undip), 9(2), 215-222.
Baietto, L., Calcagno, A., Motta, I., Baruffi, K., Poretti, V., di Perri, G., Bonora, S., & D’Avolio, A. (2015). A UPLC-MS-MS method for the simultaneous quantification of first-line antituberculars in plasma and in PBMCs. Journal of Antimicrobial Chemotherapy, 70(9), 2572–2575. https-://doi.org/10.1093/jac/dkv148
Bozorg, B. D., Goodarzi, A., Fahimi, F., Tabarsi, P., Shahsavari, N., Kobarfard, F., & Dastan, F. (2019). Simultaneous determination of isoniazid, pyrazinamide and rifampin in human plasma by high-performance liquid chromatography and uv detection. Iranian Journal of Pharmaceutical Research, 18(4), 1735–1741. https://doi.org/10.22037/ijpr.20-19.1100849
Budiarti A., Herdiyanti Y.N. (2018). Validasi Metode Penetapan Kadar Isoniazid Dan Vitamin B6 Menggunakan Kromatografi Cair Kinerja Tinggi Serta Aplikasinya Dalam Sediaan Sirup Obat Tuberkulosis. Jurnal Ilmiah Cendekia Eksakta.
Chawla, G., & Ranjan, C. (2016). Principle, Instrumentation, and Applications of UPLC: A Novel Technique of Liquid Chromat-ography. Open Chemistry Journal, 3(1), 1–16. https://doi.org/10.2174/1874842201603-010001
Chemistry, P. (2015). Ultra Perform ance Liquid Chrom atography ( UPLC ) - A Review. 2(6).
Dewi, N. M. A. R. (2019). Aplikasi Analisis Kimia Kuantitatif Untuk Pemantauan Kadar Obat (Theurapetic Drugs Monitoring). Amina, 1(1), 6–10. https://doi.org/10.22373/amina.v1i1.8
Fachi, M. M., Vilhena, R. O., Boger, B., Domingos, E. L., dos Santos, J. M. M. F., Junkert, A. M., de Fátima Cobre, A., Momade, D. R. O., Beraldi-Magalhães, F., de Liz, M. V., Cordeiro-Santos, M., & Pontarolo, R. (2020). LC–QToF–MS method for quantification of ethambutol, isoniazid, pyrazinamide and rifampicin in human plasma and its application. Biomedical Chromatography, 34(5). https://doi.org/10.1002/bmc.4812
Gao, S., Wang, Z., Xie, X., You, C., Yang, Y., Xi, Y., & Chen, W. (2018). Rapid and sensitive method for simultaneous determination of first-line anti-tuberculosis drugs in human plasma by HPLC-MS/MS: Application to therapeutic drug monitoring. Tuberculosis, 109, 28–34. https://doi.org/10.1016/j.tube.-2017.11.012
Goutal, S., Auvity, S., Legrand, T., Hauquier, F., Cisternino, S., Chapy, H., Saba, W., & Tournier, N. (2016). Validation of a simple HPLC-UV method for rifampicin determination in plasma: Application to the study of rifampicin arteriovenous concentration gradient. Journal of Pharmaceutical and Biomedical Analysis, 123, 173–178. https://doi.org/10.1016/j.jpba-.2016.02.013
Govender, K., Adamson, J. H., & Owira, P. (2018). The development and validation of a LC-MS/MS method for the quantitation of metformin, rifampicin and isoniazid in rat plasma using HILIC chromatography. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1095, 127–137. https://doi.org/-10.1016/j.jchromb.2018.07.041
Grégoire, M., Leroy, A. G., Bouquié, R., Malandain, D., Dailly, E., Boutoille, D., Renaud, C., Jolliet, P., Caillon, J., & Deslandes, G. (2016). Simultaneous determination of ceftaroline, daptomycin, linezolid and rifampicin concentrations in human plasma by on-line solid phase extraction coupled to high-performance liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 118, 17–26. https://doi.org/10.1016/j.jpba.2015.10.008
Han M., Jun H.S., Lee H., dkk. (2013). Method For Simultaneous Analysis Of Nina Second-Line Anti-Tuberculosis Drug Using UPLC-MS/MS. Journal Antimicrob Chemother. doi:10.1093/jac/dkt154
Hazarika, I. (2015). Therapeutic drug monitoring (TDM): an aspect of clinical pharmacology and pharmacy practice. Research & Reviews: A Journal of Pharmacology, 5(3), 27-34.
Hee, K. H., Seo, J. J., & Lee, L. S. (2015). Development and validation of liquid chromatography tandem mass spectrometry method for simultaneous quantification of first line tuberculosis drugs and metabolites in human plasma and its application in clinical study. Journal of Pharmaceutical and Biomedical Analysis, 102, 253–260. https://doi.org/10.1016/j.jpba.2014.09.019
Hernández-González, O., Zarazúa, S., Veytia-Bucheli, J. I., González-Chávez, M. M., Rodríguez-Pinal, C. J., Medellín-Garibay, S. E., Uresti-Rivera, E. E., Pérez-Vázquez, F. J., Portales-Pérez, D. P., Romano-Moreno, S., & Milán-Segovia, R. del C. (2021). Quantification of pyrazinamide, isoniazid, acetyl-isoniazid, and rifampicin by a high-performance liquid chromatography method in human plasma from patients with tuberculosis. Journal of Separation Science, 44(2), 521–529. https://doi.org/10.1002/-jssc.202000672
Ingle, A., Baheti, M., Wate, S., Bhusari, K., & Ingle, A. (2017). International Journal of Advances in Pharmaceutical Analysis Bio-analytical method validation and its 57 importance in Pharma research-A Review Article QR Code *Correspondence Info. International Journal of Advances in Pharmaceutical Analysis, 04, 7. https://doi.org/10.7439/ijapa
Jang, S. H., Yan, Z., & Lazor, J. A. (2016). Therapeutic drug monitoring: A patient management tool for precision medicine. Clinical Pharmacology and Therapeutics, 99(2), 148–150. https://doi.org/10.1002-/cpt.298
John. E., Lin.E., Zhao. Y., Zurlinden. E. (2002). A High-Pressure Chromatographic-Tandem Mass Spectrometric Method For The Determination Of Ethambutol in Human Plasma, Bronchoalveolar Lavage Fluid, and Alveolar Cells. Journal of Chromatographic Science. Vol 40.
Jourdil, J. F., Tonini, J., & Stanke-Labesque, F. (2013). Simultaneous quantitation of azole antifungals, antibiotics, imatinib, and raltegravir in human plasma by two-dimensional high-performance liquid chro-matography tandem mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 919–920, 1–9. https://doi.-org/10.1016/j.jchromb.2012.12.028
Ju, W., Peng, K., Yang, S., Sun, H., Sampson, M., & Wang, M. Z. (2014). A chiral HPLC-MS/MS method for simultaneous quantification of warfarin enantiomers and its major hydroxylation metabolites of CYP2C9 and CYP3A4 in human plasma. Austin journal of analytical and pharmaceutical chemistry, 1(2).
Kautsar, A. P., & Intani, T. A. (2016). Kepatuhan dan Efektivitas Terapi Obat Anti Tuberkulosis (OAT) Kombinasi Dosis Tetap (KDT) dan Tunggal pada Penderita TB Paru Anak di Salah Satu Rumah Sakit di Kota Bandung. Jurnal Farmasi Klinik Indonesia, 5(3), 215-224.
Kemenkes RI. (2023, April 11). Indonesia Raih Rekor Capaian Deteksi TBC Tertinggi di Tahun 2022. Retrieved from Kementrian Kesehatan Direktorat Promosi Kesehatan dan Pemberdayaan Masyarakat: https://pro-mkes.kemkes.go.id/indonesia-raih-rekor-capaian-deteksi-tbc-tertinggi-di-tahun-2022
Kim, H. J., Seo, K. A., Kim, H. M., Jeong, E. S., Ghim, J. L., Lee, S. H., Lee, Y. M., Kim, D. H., & Shin, J. G. (2015). Simple and accurate quantitative analysis of 20 anti-tuberculosis drugs in human plasma using liquid chromatography electrospray ioniz-ation tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 102, 9–16. https://doi.org/10.1016/j.jpba.20-14.08.026
Kusuma, A. S. W., & Ismanto, R. M. H. (2016). Penggunaan Instrumen High-Performance Liquid Chromatography Sebagai Metode Penentuan Kadar Kapsaisin Pada Bumbu Masak Kemasan “Bumbu Marinade Ayam Special” Merek Sasa. Jurnal Farmaka, 14(2), 41–46.
Lee, K., Jun, S. H., Choi, M. S., Song, S. H., Park, J. S., Lee, J. H., Park, K. U., & Song, J. (2017). Application of the isoniazid assay in dried blood spots using the ultra-performance liquid chromatography-tandem mass spectrometry. Clinical Biochemistry, 50(15), 882–885. https://doi.org/10.1016/-j.clinbiochem.2017.04.010
Li, W., Peng, M., Long, M., Qiu, X., & Yang, L. (2014). Novel on-line column extraction apparatus coupled with binary peak focusing for high-performance liquid chromatography determination of rifampicin in human plasma: A strategy for therapeutic drug monitoring. Journal of Separation Science, 37(24), 3603–3609. https://doi.org/10.10-02/jssc.201400714
Louveau, B., Fernandez, C., Zahr, N., Sauvageon-Martre, H., Maslanka, P., Faure, P., Mourah, S., & Goldwirt, L. (2016). Determination of rifampicin in human plasma by high-performance liquid chromatography coupled with ultraviolet detection after automatized solid–liquid extraction. Biomedical Chromat-ography, 30(12), 2009–2015. https://doi.org-/10.1002/bmc.3778
Luyen T.L., Hung M.T., Tuan A.L., dkk. (2018). Simultaneous Determination of Pyrazinamide, Rifampicin, Ethambutol, Isoniazid and Acetyl Isoniazid in Human Plasma by LC-MS/MS Method. Jounal of Applied Pharmaceutical Science. Vol 8(09).
Panda, B. K., Bargaje, M., & Sathiyanarayanan, L. (2020). A simple and reliable analytical method for simultaneous quantification of first line antitubercular drugs in human plasma by LCMS/MS. Analytical Methods, 12(31), 3909–3917. https://doi.org/10.1039/-d0ay00889c
Papamichael, K., Casteele, N. Vande, Ferrante, M., Gils, A., & Cheifetz, A. S. (2017). Therapeutic Drug Monitoring during Induction of Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease: Defining a Therapeutic Drug Window. Inflammatory Bowel Diseases, 23(9), 1510–1515. https://doi.org/10.1097/MIB.000000-0000001231
Prawiranata H.P.I., Sugiastana N.B., dkk. Pengembangan Metode HPTLC-Spektrofotodensitometri Untuk Pemisahan Senyawa Rifampisin, Isoniazid, Pirazi-namida, dan Etambutol. Fakultas Kedok-teran Universitas Udayana.
Rafflesia, U. (2014). Model penyebaran penyakit tuberkulosis (TBC). Gradien, 10(2), 983-986.
Rizalina, H., Cahyono, E., Mursiti, S., & Nurcahyo, B. (2018). Optimasi Penentuan Kadar Metanol dalam Darah Menggunakan Gas Chromatography. Indonesian Journal of Chemical Science, 7(3), 254–261.
Rosydiati., Saleh K.E. (2019). Karakterisasi Puncak Kromatogram Dalam High Performance Liquid Chromatography (Hplc) Terhadap Perbedaan Fase Gerak, Laju Alir, Dan Penambahan Asam Dalam Analisis Indole Acetic Acid (IAA). Kandaga. Vol 1(2).
Sarkar, S., & Ganguly, A. (2016). Current Overview of Anti-Tuberculosis Drugs: Metabolism and Toxicities. Mycobacterial Diseases, 6(2). https://doi.org/10.4172/216-1-1068.1000209
Setiawan. J., Sari. A.N.M.P. (2022). Metode Analisis Rifampisin Dalam Plasma Darah. Journal Transformation of Mandalika. Vol 3(4).
Sholihah, S., Putriana, N. A., & Pratiwi, R. (2021). Review Metode Analisis Warfarin dalam Plasma dengan Berbagai Instrumen. Jurnal Sains Farmasi & Klinis, 8(2), 128-144.
Soedarsono, S. (2021). Tuberculosis: Develo-pment of New Drugs and Treatment Regimens. Jurnal Respirasi, 7(1), 36. https://doi.org/10.20473/jr.v7-i.1.2021.36-45
Sumarno, D., & Kusumaningtyas, D. I. (2018). Penentuan Limit Deteksi Dan Limit Kuantitasi Untuk Analisis Logam Timbal (Pb) Dalam Air Tawar Menggunakan. Jurnal Balitbang KKP, 16, 7–11.
Tamargo, J., Le Heuzey, J. Y., & Mabo, P. (2015). Narrow therapeutic index drugs: A clinical pharmacological consideration to flecainide. European Journal of Clinical Pharmacology, 71(5), 549–567. https://doi.org/10.1007/-s00228-015-1832-0
Torowati, & Galuh, B. S. (2014). Penentuan nilai limit deteksi dan kuantisasi alat titrasi potensiometer untuk analisis uranium. Jurnal Batan, 13, 9–15. http://jurnal.batan.go.id/index.php/pin/article/view/1371/1302
Tuzimski, T., & Petruczynik, A. (2020). Review of chromatographic methods coupled with modern detection techniques applied in the therapeutic drugs monitoring (TDM). Molecules, 25(17), 4026.
Van Der Werf, M. J., Hollo, V., Ködmön, C., Dara, M., & Catchpole, M. (2017). Eligibili3ty for shorter treatment of multidrug-resistant tuberculosis in the European Union. European Respiratory Journal, 49(3), 10–13. https://doi.org/10.1183/13993003.01992-2016
Vidushi, Y., & Meenakshi, B. (2017). A Review On HPLC Method Development And Validation. Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Chemistry, 2(6), 166–178. https://doi.org/10.26479/2017.0206.12
Vu, D. H., Koster, R. A., Bolhuis, M. S., Greijdanus, B., Altena, R. V., Nguyen, D. H., Brouwers, J. R. B. J., Uges, D. R. A., & Alffenaar, J. W. C. (2014). Simultaneous determination of rifampicin, clarithromycin and their metabolites in dried blood spots using LC-MS/MS. Talanta, 121, 9–17. https://doi.org/10.1016/j.talanta.2013.12.043
Wang, X., Zhang, H., Han, Y., Huo, L., Cao, Y., Xu, X., & Ai, L. (2020). Rapid and simultaneous determination of ten anti-tuberculosis drugs in human plasma by UPLC-MS/MS with applications in therapeutic drug monitoring. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1152. https://doi.org/10.1016/j.jchromb.2020.122246
Wang, X., Zhang, H., Han, Y., Huo, L., Cao, Y., Xu, X., & Ai, L. (2020). Rapid and simultaneous determination of ten anti-tuberculosis drugs in human plasma by UPLC-MS/MS with applications in therapeutic drug monitoring. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1152. https://doi.org/10.1016/j.jchromb.2020.122246
Wang, Z., Xie, C., Yeung, S., Wang, J., & Chow, M. S. S. (2019). Development of a simple and rapid HPLC-MS/MS method for quantification of streptomycin in mice and its application to plasma pharmacokinetic studies. Biomedical Chromatography, 33(2). https://doi.org/10.1002/bmc.4408
WHO. (2022). Global Tuberculosis reporT 2022. http://apps.who.int/bookorders.
Winchester, L. C., Podany, A. T., Baldwin, J. S., Robbins, B. L., & Fletcher, C. V. (2015). Determination of the rifamycin antibiotics rifabutin, rifampin, rifapentine and their major metabolites in human plasma via simultaneous extraction coupled with LC/MS/MS. Journal of Pharmaceutical and Biomedical Analysis, 104, 55–61. https://doi.org/10.1016/j.jpba.2014.11.011
World Health Organization (WHO). (2016). WHO treatment guidelines for drug- resistant tuberculosis 2016. WHO Library Catalo-guing in Publication Data, October, 1–64.
Wu, L., Ye, Z., Liu, H., Guo, H., Lin, J., Zheng, L., Chu, N., & Liu, X. (2020). Rapid and highly sensitive quantification of the anti-tuberculosis agents isoniazid, ethambutol, pyrazinamide, rifampicin and rifabutin in human plasma by UPLC-MS/MS. Journal of Pharmaceutical and Biomedical Analysis, 180. https://doi.org/10.1016/j.jpba.2019.113-076
Xing, Y., Yin, L., Le, X., Chen, J., Zhang, L., Li, Y., Lu, H., & Zhang, L. (2021). Simultaneous determination of first-line anti-tuberculosis drugs and one metabolite of isoniazid by liquid chromatography/tandem mass spectrometry in patients with human immunodeficiency virus tuberculosis coinf-ection. Heliyon, 7(7), e07532. https://doi.-org/10.1016/j.heliyon.2021.e07532
Yantih, N., Harahap, Y., Sumaryono W., dkk. (2019). Selektivitas Pemisahan Isoniazid dan Asetilisoniazid dalam Plasma Manusia In-Vitro Secara Kromatografi Cair Kinerja Tinggi. Jurnal Ilmu Kefarmasian Indonesia. Vol 17(2).
Zhang, X., Wang, R., Xie, H., Jia, Z., Li, W., Zhang, J., & Wang, Y. (2015). Determination of rifampicin in rat plasma by modified large-volume direct injection RAM-HPLC and its application to a pharmcokinetic study. Biomedical Chromatography, 29(3), 475–480. https://doi.org/10.1002/bmc.3303