Comparison of Analysis Methods of Compound Levels and Mercury (Hg) Toxicity in Biological Samples
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Page: 863-875
Abstract
Mercury or mercury (Hg) is a type of metal as an organic and inorganic compound that can be found in nature and is spread in rocks, ores, soil, water and air. Mercury in the body can be detected in biological materials such as urine, blood, breast milk and hair. This study aims to analyze the content and toxicity of mercury (Hg) in biological samples such as blood, hair, urine and breast milk with various analytical methods including CV-AAS, AAS, CV-AFS, ICP-MS, FI-CV-AAS, and Mercury Analyzers. Data collection was based on the Literature Review by collecting several published research journals both at national and international levels which were filtered according to inclusion and exclusion criteria using the PRISMA method (Preferred Reporting Item for Systematic Review and Meta-Analysis). The method used depends on the needs of the analysis, its sensitivity and availability. Of the several methods used, AAS or atomic absorption spectrophotometry is the most commonly used method, because this method is simple and considered fast for analyzing mercury levels in biological samples.
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References
Adhani, R., Husaini. (2017). Logam Berat Sekitar Manusia. Banjarmasin: Lambung Mangkurat University Press.
Akram, S., Najam, R., Rizwani, G. H., & Abbas, S. A. (2015). Determination of heavy metal contents by atomic absorption spectroscopy (AAS) in some medicinal plants from Pakistani and Malaysian origin. In Pak. J. Pharm. Sci. 28(5); 1781-1787.
Al-Sulaiti, M. M., Soubra, L., & Al-Ghouti, M. A. (2022). The Causes and Effects of Mercury and Methylmercury Contamination in the Marine Environment: A Review. Current Pollution Reports. 8(3), 249–272. Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/s40726-022-00226-7
Aprianne, D., & Rachmatiah, I. (2014). Analisa Pengukuran Kandungan Merkuri Pada Beras Dan Sedimen Di Sekitar Kegiatan Pertambangan Emas Skala Kecil (Pesk) Di Kasepuhan Adat Cisitu, Kecamatan Cibeber, Kabupaten Lebak, Provinsi Banten. Jurnal Tehnik Lingkungan, 20(2), 120–131. https://doi.org/10.5614/jtl.2014.20.2.3
Astika, T. J. (2022). Identifikasi Merkuri Pada Pekerja Tambang Emas Berdasarkan Varian Sampel Uji Dan Durasi Kerja: Literature Review. Yogyakarta: Universitas As’Asisyiyah.
Astolfi, M. L., Protano, C., Marconi, E., Piamonti, D., Massimi, L., Brunori, M., Vitali, M., & Canepari, S. (2019). Simple and rapid method for the determination of mercury in human hair by cold vapour generation atomic fluorescence spectrometry. Microchemical Journal, 150, 104186. https://doi.org/10.1016/j.microc.2019.104186
Ballesteros, L.M. T., García Barrado, B., Navarro Serrano, I., Izquierdo Álvarez, S., del Pueyo García Anaya, M., & González Muñoz, M. J. (2020). Evaluation of blood mercury and serum selenium levels in the pregnant population of the Community of Madrid, Spain. Journal of Trace Elements Medicine and Biology, 57, 60–67. https://doi.org/10.1016/j.jtemb.2019.09.008
Bose-O’Reilly, S., Lettmeier, B., Shoko, D., Roider, G., Drasch, G., & Siebert, U. (2020). Infants and mothers levels of mercury in breast milk, urine and hair, data from an artisanal and small-scale gold mining area in Kadoma / Zimbabwe. Environmental Research, 184, 109266. https://doi.org/10.1016/j.envres.2020.109266
BPOM (Badan Pengawasan Obat dan Makanan Republik Indonesia). 2004. Info POM. Jurnal Vol. 5, No. 4,Juli 2004.
Branco, V., Caito, S., Farina, M., Teixeira da Rocha, J., Aschner, M., & Carvalho, C. (2017). Biomarkers of mercury toxicity: Past, present, and future trends. Journal of Toxicology and Environmental Health - Part B: Critical Reviews, 20(3), 119–154. https://doi.org/10.1080/10937404.2017.1289834
Desimal, I. (2018). Hubungan Pertambangan Emas Dengan Kadar Merkuri Dalam Rambut Penambang Di Desa Kedaro Sekotong Lombok Barat. Jurnal Sangkareng Mataram, 4(1), 56–59. http://www.untb.ac.id/maret-2018/
Pridianata,E. V., Tualeka, R. A., Lain, B., Rahmawati, P., Russeng, S. S., & Wahyu, A. (2019). Determination of Dosage Reference (RfD) of Mercury Based on NOAEL and characteristics of Workers in the Area of Unlicensed Gold Mining (PETI) Maluku Province Indonesia. In 1170 Indian Journal of Public Health Research & Development. 10(9),1170-1175.
EMA. (2019). International Council of Harmonisation Guideline M10 on Bioanalytical Method Validation Vol. 44. London: European Medicines Agency.
Faith, D., Biambo, K. G., Nyebuchi, J., Amadi, C. F., & Konne, F. E. (2021). Comparative Study of Heavy Metals in Breast Milk of Breast Feeding Mothers in Urban and Sub-Urban Subjects in Rivers State. Journal of Applied Life Sciences International, 31–36. https://doi.org/10.9734/jalsi/2021/v24i830255
Hasyimi, M., Rahim, Y., Betryon. (2014). Persepsi Jajaran Kesehatan Tentang Dampak Kegiatan Penambangan Emas di Kabupaten Buru Provinsi Maluku, Tahun 2012. Jurnal Ekologi Kesehatan. 13(2), 86-94.
Sofia, Husodo, A.H. (2016). Kontaminasi Merkuri Pada Sampel Lingkungan Dan Faktor Risiko Pada Masyarakat Dari Kegiatan Penambangan Emas Skala Kecil Krueng Sabee Provinsi Aceh. Jurnal Manusia dan Lingkungan. 23(3), 310-318.
Iwai-Shimada, M., Kobayashi, Y., Isobe, T., Nakayama, S. F., Sekiyama, M., Taniguchi, Y., Yamazaki, S., Michikawa, T., Oda, M., Mitsubuchi, H., Sanefuji, M., Ohga, S., Mise, N., Ikegami, A., Suga, R., & Shimono, M. (2021). Comparison of simultaneous quantitative analysis of methylmercury and inorganic mercury in cord blood using LC-ICP-MS and LC-CVAFS: The pilot study of the Japan environment and children’s study. Toxics, 9(4). https://doi.org/10.3390/toxics9040082
Iwan, P. A., & Niken, P. (2020). Pengaruh Pajanan Merkuri Dari Bahan Makanan Terhadap Kandungan Merkuri Dalam Darah Ibu Menyusui Di Daerah Pertambangan Emas. Jurnal Riset Kesehatan Poltekkes Depkes Bandung, 12(1), 224–235.
Junita, N. R. (2013). Risiko Keracunan Merkuri (Hg) Pada Pekerja Penambangan Emas Tanpa Izin (Peti) Di Desa Cisarua Kecamatan Nanggung Kabupaten Bogor. SKRIPSI. Jakarta: Universitas Islam Negri Syarif Hidayatullah.
Karyanah, Y. (2013). Analisa Komparasi Kadar Logam Berat Mercuri pada Urine Pasien Kanker Payudara dengan Kada Logam Berat Mercuri pada Urine Wanita Sehat. Jurnal Inohim. 1(2), 88-98.
Kim, S.-A., Kwon, Y., Kim, S., & Joung, H. (2016). Assessment of Dietary Mercury Intake and Blood Mercury Levels in the Korean Population: Results from the Korean National Environmental Health Survey 2012–2014. International Journal of Environmental Research and Public Health, 13(9), 877. https://doi.org/10.3390/ijerph13090877
Malek, A., Aouad, K., El khoury, R., Halabi-Tawil, M., & Choucair, J. (2017). Chronic Mercury Intoxication Masquerading as Systemic Disease: A Case Report and Review of the Literature. European Journal of Case Reports in Internal Medicine. https://doi.org/10.12890/2017_000623
Mestria, S., Odoardi, S., Federici, S., Bilel, S., Tirri, M., Marti, M., & Rossi, S. S. (2020). Metabolism Study of N-Methyl 2-amino Indane (NM2AI) and Determination of Metabolites in Biological Samples by LC-HRMS Metabolism Study of NM2AI by LC-HRMS. Oxford University Press, 1–22. https://doi.org/10.1093/jat/bkaa111/5899167
Mostafavi, S. M., & Ebrahimi, A. (2019). Mercury determination in work place air and human biological samples based on dispersive liquid-liquid micro-extraction coupled with cold vapor atomic absorption spectrometry. Analytical Methods in Environmental Chemistry Journal, 2(4), 49–58.
Mulyadi, I., Putrajaya, F., Hasanah, N., & Sumiyati, S. (2021). Mercury content on hair as an indication of mercury exposure on gold miners in Tambang Sawah Village, Lebong Regency. Annals of Tropical Medicine & Public Health, 24(01). https://doi.org/10.36295/asro.2021.24103
Musafira, & Rasul, E. (2022). Analisis Kadar Merkuri (Hg) pada Rambut Pekerja Tambang di Pertambangan Emas Tanpa Ijin (PETI) Kabupaten Parigi Moutong dalam Hubungannya dengan Frekuensi Konsumsi Ikan. KOVALEN: Jurnal Riset Kimia, 8(3), 308–313. https://doi.org/10.22487/kovalen.2022.v8.i3.16121
Nasir, M., Rahmah, W., Khaldun, I., Hasan, M., & Rusman, R. (2021). Analisis Kadar Merkuri Dalam Rambut Penambang Emas Desa Alue Baro Kecamatan Meukek Secara Spektrofotometri Serapan Atom. Jurnal IPA & Pembelajaran IPA, 5(4), 269–278. https://doi.org/10.24815/jipi.v5i4.22654
Rice, K. M., Walker, E. M., Wu, M., Gillette, C., & Blough, E. R. (2014). Environmental Mercury and Its Toxic Effects. Journal of Preventive Medicine & Public Health, 47(2), 74–83. https://doi.org/10.3961/jpmph.2014.47.2.74
Santa-Rios, A., Barst, B. D., & Basu, N. (2020). Mercury Speciation in Whole Blood and Dried Blood Spots from Capillary and Venous Sources. Analytical Chemistry, 92(5), 3605–3612. https://doi.org/10.1021/acs.analchem.9b04407
Shirkhanloo, H., Khaligh, A., Mousavi, H. Z., Eskandari, M. M., & Miran-Beigi, A. A. (2015). Ultra-trace arsenic and mercury speciation and determination in blood samples by ionic liquid-based dispersive liquid–liquid microextraction combined with flow injection-hydride generation/cold vapor atomic absorption spectroscopy. Chemical Papers, 69(6), 779-790. https://doi.org/10.1515/chempap-2015-0086
Sholihah, S., Putriana, N. A., & Pratiwi, R. (2021). Review Metode Analisis Warfarin dalam Plasma dengan Berbagai Instrumen. Jurnal Sains Farmasi & Klinis, 8(2), 128. https://doi.org/10.25077/jsfk.8.2.128-144.2021
Soleymani, D., Zargari, S., & Faghihi-Zarandi, A. (2020). Separation and determination of mercury from nail and hair in petrochemical workers based on silver carbon nanotubes by microwave-assisted headspace sorbent trap. In Anal. Method Environ. Chem. J. 3(2), 21-33.
Taux, K., Kraus, T., & Kaifie, A. (2022). Mercury Exposure and Its Health Effects in Workers in the Artisanal and Small‐Scale Gold Mining (ASGM) Sector—A Systematic Review. In International Journal of Environmental Research and Public Health. 19(2081), 1-34. https://doi.org/10.3390/ijerph19042081
Wang, M.B., Wang, K. (2014). Flavour Frag. Cosmetics. 42(36)
World Health Organization. (1990). Environmental Health Criteria 101: Methylmercury. Geneva.