Isi Artikel Utama

Siti Nafisa
Siti Rohmah
Yumareta Anggun Nihan
Lina Nurfadhila
Marsah Rahmawati Utami

Page: 479-494

Abstrak

Warfarin merupakan turunan sintetik kumarin yang penggunaannya sebagai antikoagulan oral yang biasa digunakan untuk mencegah dan mengobati penggumpalan darah, profilaksis dan pengobatan emboli paru dan trombosis vena, profilaksis dan pengobatan komplikasi tromboemboli dari fibrilasi atrium atau penggantian katup jantung, serta risiko kematian dari infark miokard berulang, dan kejadian tromboemboli setelah infark miokard dapat di kurangi. Warfarin merupakan indeks terapi sempit antikoagulan oral yang apabila adanya perubahan sedikit kadar obat warfarin pada darah maka dapat terdadi perubahan respons efek. telah banyak dikembangkan berbagai teknik analitik bagi analisis kadar warfarin yang ada dalam plasma darah, contohnya seperti menggunakan High-Performance Liquid Chromatography ditambah dengan deteksi ultraviolet/fluoresensi, SFC-MS/MS, LC-MS/MS, CZE dengan deteksi ultraviolet, dan MEKC-ESI–MS. Metode uji yang digunakan untuk pemantauan Artikel Review ini  memiliki tujuan sebagai tinjauan dan  perbandingan metode analisis/teknik pendeteksian yang digunakan pada analisis warfarin yang ada dalam plasma darah. Metode HPLC memiliki beberapa keuntungan dalam analisis kadar obat warfarin, yaitu seperti kemudahan, keakuratan, efektifitas waktu analisa, serta keunggulan sensitivitas dan selektivitas yang tinggi.

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Nafisa, S., Rohmah, S., Nihan, Y. A., Nurfadhila, L., & Utami, M. R. (2023). Review: Analisis Senyawa Obat Warfarin dalam Plasma Darah dengan Metode HPLC/KCKT. Journal of Pharmaceutical and Sciences, 6(2), 479–494. https://doi.org/10.36490/journal-jps.com.v6i2.143
Bagian
Review Article

Referensi

Abdallah, N. A. (2014). HPLC and densitometric TLC methods for simultaneous determination of gemifloxacin with some co-administered drugs in human plasma. Journal of Chromatography & Separation Techniques, 5(2), 1.

Ahmadi, F., Yawari, E., & Nikbakht, M. (2015). Computational design of an enantioselective molecular imprinted polymer for the solid phase extraction of S-warfarin from plasma. J of Chromatography A, 1338, 9-16.

Alaydrus, H., Suharto, G., & Amarwati, S. (2015). Analisa Gambaran Post Mortem Makroskopis Dan Mikroskopis Otak Dan Hati Pada Tikus Wistar Setelah Pemberian Warfarin Ld-50 Dan Ld-100. Diponegoro University.

Alexander, P., Visagan, S., Issa, R., Gorantla, V. R., & Thomas, S. E. (2021). Current Trends in the Duration of Anticoagulant Therapy for Venous Thromboembolism: A Systematic Review. Cureus, 13(10), e18992. https://doi.org/10.7759/cureus.18992

Alnaqeeb, M., Mansor, K. A., Mallah, E. M., Ghanim, B. Y., Idkaidek, N., & Qinna, N. A. (2019). Critical pharmacokinetic and pharmacodynamic drug-herb interactions in rats between warfarin and pomegranate peel or guava leaves extracts. BMC Complementary and Alternative Medicine, 19(1), 1–12. https://doi.org/10.1186/s12906-019-2436-5

Angraini, N., & Desmaniar, P. (2020). Optimasi penggunaan High Performance Liquid Chromatography (HPLC) untuk analisis asam askorbat guna menunjang kegiatan Praktikum Bioteknologi Kelautan. Jurnal Penelitian Sains, 22(2), 69. https://doi.org/10.56064/jps.v22i2.583

Bandforuzi SR, Hadjmohammadi MR. (2017). Solvent bar microextraction using a reverse micelle containing extraction phase for the determination of warfarin from human plasma by high-performance liquid chromatography. J Chromatogr A, 1496, 1–8. http://dx.doi.org/10.1016/j.chroma.2017.03.037.

Chernonosov, A. (2016). Quantification of warfarin in dried rat plasma spots by high-performance liquid chromatography with tandem mass spectrometry. Journal of Pharmaceutics.

Chua, Y. A., Abdullah, W. Z., & Gan, S. H. (2012). Development of a high-performance liquid chromatography method for warfarin detection in human plasma. Turkish Journal of Medical Sciences, 42(5), 930-941.

Chua, Y. A., Abdullah, W. Z., Yusof, Z., & Gan, S. H. (2019). Validation of HPLC and liquid-liquid extraction methods for warfarin detection in human plasma and its application to a pharmacokinetics study. ASM Science J, 12, 1-10.

Ding, T., Zhang, Y., Chen, A., Tang, Y., Liu, M., & Wang, X. (2015). Effects of cucurbitacin E, a tetracyclic triterpene compound from Cucurbitaceae, on the pharmacokinetics and pharmacodynamics of warfarin in rats. Basic & Clinical Pharmacology & Toxicology, 116(5), 385-389.

Doliner, B., Jaller, J. A., Lopez, A. J., & Lev-Tov, H. (2019). Treatments to prevent primary venous ulceration after deep venous thrombosis. Journal of Vascular Surgery: Venous and Lymphatic Disorders, 7(2), 260-271.e1. https://doi.org/10.1016/j.jvsv.2018.12.009

Fauzy, M. R., Sinuraya, R. K., & Putriana, N. A. (2020). Instrumen Monitoring Pasien Dalam Terapi Warfarin. Majalah Farmasetika, 5(4), 156–166. https://doi.org/10.24198/mfarmasetika.v5i4.27821

Fauzy, M. R., & Susilawati, Y. (2020). Metode Analisa Warfarin. Farmaka, 18(1), 119-128.

Ghambari, H., & Hadjmohammadi, M. (2012). Low-density solvent-based dispersive liquid–liquid microextraction followed by high performance liquid chromatography for determination of warfarin in human plasma. J of Chromatography B, 899, 66-71.

Hadjmohammadi, M., & Ghambari, H. (2012) Three-phase hollow fiber liquid phase microextraction of warfarin from human plasma and its determination by high-performance liquid chromatography. Journal of pharmaceutical and biomedical analysis, 61, 44-49.

Kobayashi, S., Ishii, K., Yamada, Y., Ryu, E., Hashizume, J., Nose, S., ... & Ohyama, K. (2019). Combination index of the concentration and in vivo antagonism activity of racemic warfarin and its metabolites to assess individual drug responses. J of Thrombosis and Thrombolysis, 47, 467-472.

Kumar, D. K., Shewade, D. G., Parasuraman, S., Rajan, S., Balachander, J., Chandran, B. S., & Adithan, C. (2013). Estimation of plasma levels of warfarin and 7-hydroxy warfarin by high performance liquid chromatography in patients receiving warfarin therapy. Journal of Young Pharmacists, 5(1), 13-17.

Li, W., Bu, F., Li, R., Wang, B., Shaikh, A. S., Zhang, Y., ... & Zhang, R. (2018). Bioequivalence Study of Warfarin in Healthy Chinese Volunteers With a Validated High‐Performance Liquid Chromatography‐Mass Spectrometry Method. Clinical Pharmacology in Drug Development, 7(3), 256-262.

Lomonaco, T., Ghimenti, S., Piga, I., Onor, M., Melai, B., Fuoco, R., & Di Francesco, F. (2013). Determination of total and unbound warfarin and warfarin alcohols in human plasma by high performance liquid chromatography with fluorescence detection. J of Chromatography A, 1314, 54-62.

Lomonaco, T., Ghimenti, S., Piga, I., Biagini, D., Onor, M., Fuoco, R., & Di Francesco, F. (2014). Influence of sampling on the determination of warfarin and warfarin alcohols in oral fluid. PloS one, 9(12), 114430.

Lomonaco, T., Ghimenti, S., Piga, I., Biagini, D., Onor, M., Fuoco, R., ... & Di Francesco, F. (2018). Monitoring of warfarin therapy: Preliminary results from a longitudinal pilot study. J Microchemical, 136, 170-176.

Majidi, S. M., & Hadjmohammadi, M. R. (2020). Hydrophobic borneol-based natural deep eutectic solvents as a green extraction media for air-assisted liquid-liquid micro-extraction of warfarin in biological samples. Journal of Chromatography A, 1621, 461030. https://doi.org/10.1016/j.chroma.2020.461030

Mirmanto, M., Sutanto, R., & Putra, D. K. (2018). Unjuk Kerja Kotak Pendingin Termoelektrik dengan Variasi Laju Aliran Massa Air Pendingin. None, 7(1), 44-49.

Mullokandov, E., Ahn, J., Szalkiewicz, A., & Babayeva, M. 2014.Protein binding drug-drug interaction between warfarin and tizoxanide in human plasma.

Nosal, D. G., Feinstein, D. L., Chen, L., & van Breemen, R. B. (2020). Separation and quantification of superwarfarin rodent-icide diastereomers broma-diolone, difenacoum, flocoumafen, brodifacoum, and difethialone in human plasma. Journal of AOAC International, 103(3), 770-778.

Oktaviani, D. J., Widiyastuti, S., Maharani, D. A., Amalia, A. N., Ishak, A. M., & Zuhrotun, A. (2020). Farmaka Farmaka. Farmaka, 18(1), 1–15.

Osman, A., Arbring, K., & Lindahl, T. L. (2005). A new high-performance liquid chroma-tographic method for determination of warfarin enantiomers. Journal of Chromatography B, 826(1-2), 75-80.

Patel S, Singh R, Preuss C V, Patel N. 2023. Warfarin. In: StatPearls Publishing. Available from: https://www.ncbi.nl-m.nih.gov/books/NBK470313/.

Peyrovi, M., & Hadjmohammadi, M. (2015). Synthesis of molecularly imprinted polypyrrole as an adsorbent for solid‐phase extraction of warfarin from human plasma and urine. Biomedical Chromatography, 29(11), 1623-1628.

Peyrovi, M., & Hadjmohammadi, M. (2015). Supramolecular solvent-based microextraction of warfarin from biological samples and its determination using HPLC. J of the Iranian Chemical Society, 12, 1253-1259.

Putriana, N. A., Rusdiana, T., Rostinawati, T., Akbar, M. R., Saputri, F. A., & Utami, S. (2022). Validation of warfarin enantiomer analysis method in plasma using high-performance liquid chromatography fluorescence detector. Journal of advanced pharmaceutical technology & research, 13(1), 18–24. https://doi.org/10.4103/japtr.japtr_259_21

Qayyum, A., Najmi, M. H., Khan, A. M., Abbas, M., Naveed, A. K., & Jameel, A. (2015). Determination of S-and R-warfarin enantiomers by using modified HPLC method. Pakistan J of Pharma Scien. 28(4).

Ranjbar Bandforuzi, S., & Hadjmohammadi, M. R. (2017). Solvent bar microextraction using a reverse micelle containing extraction phase for the determination of warfarin from human plasma by high-performance liquid chromatography. Journal of Chromatography A, 1496, 1–8. https://doi.org/10.1016/j.chroma.201-7.03.037

Regalado, E. L., Schariter, J. A., & Welch, C. J. (2014). Investigation of two-dimensional high performance liquid chromatography approaches for reversed phase resolution of warfarin and hydroxywarfarin isomers. J of Chroma, 1363, 200-206.

Rodina, T. A., Melnikov, E. S., Aksenov, A. A., Belkov, S. A., Sokolov, A. V., Prokof’ev, A. B., & Ramenskaya, G. V. (2022). Simultaneous Determination of Dabigatran, Rivaroxaban, Apixaban, and Warfarin in Human Blood Serum by HPLC-MS/MS for Therapeutic Drug Monitoring. Pharmaceutical Chemistry J, 56(2), 289-293.

Rohayati, A., Hasanah, A. N., Saptarini, N. M., & Aryanti, A. D. (2015). Optimasi kondisi pemisahan glibenklamid kombinasi metformin dalam plasma darah menggunakan KCKT. Indonesian Journal of Pharmaceutical Science and Technology, 2(3), 96.

Sastrohamidjojo, H. 2018. Dasar-dasar spektroskopi. Yogyakarta: UGM Press.

Savitri, I., Suhendra, L., & Wartini, N. M. (2017). Pengaruh jenis pelarut pada metode maserasi terhadap karakteristik ekstrak Sargassum polycystum. Jurnal Rekayasa dan Manajemen Agroindustri, 5(3), 93-101.

Sharp, C. R., DeLaforcade, A. M., Koenigshof, A. M., Lynch, A. M., & Thomason, J. M. (2019). Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE): Domain 4-Refining and monitoring antithrombotic therapies. Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001), 29(1), 75–87. -https://doi.org/10.-1111/vec.12794

Shen, C., Huang, X., Li, J., Zhang, P., Li, L., Zhang, W., & Tang, H. (2016). Pharmacokinetic and pharmacodynamic interactions of aspirin with warfarin in beagle dogs. Xenobiotica, 46(6), 530-541.

Sholihah, S., Putriana, N. A., & Pratiwi, R. (2021). Review Metode Analisis Warfarin dalam Plasma dengan Berbagai Instrumen. Jurnal Sains Farmasi & Klinis, 8(2), 128. https://doi.org/10.25077/jsfk.8.2.128144.2021

Sornsuvit, C., Niamhun, N., Luengpiansamut, N. U. T. T. H. I. D. A., Sangsrijan, S., Niwatananum, W., Kaewvichit, S. A. Y. A. M., & Yotsawimonwat, S. (2015). Pharmacokinetics and bioequivalence studies of warfarin sodium 5 milligrams tablet in healthy Thai subjects. International Journal of Pharmacy and Pharmaceutical Sciences, 7(3), 219-222.

Susanti, H., Araaf, N. P. M., & Kusbandari, A. (2019). Perbandingan metode spektrofotometri UV dan HPLC pada penetapan kadar kafein dalam kopi. Majalah Farmasetika, 4, 28-33.

Ueng, Y. F., Lu, C. K., Yang, S. H., Wang, H. J., & Huang, C. C. (2017). Potentiation of the anticoagulation effect of warfarin by the herbal remedy Shu-Jing-Hwo-Shiee-Tang in rats: The dosing regimen and pharmacokinetic interaction. Drug metab and pharma, 32(1), 85-91.

Ueng YF, Lu CK, Yang SH, Wang HJ, Huang CC. (2017). Potentiation of the anticoagulation effect of warfarin by the herbal remedy Shu-JingHwo-Shiee-Tang in rats: The dosing regimen and pharmacokinetic interaction. Drug Metab Pharmacokinet, 32(1), 85–91.

Ye, H., Sui, D., Liu, W., Yuan, Y., Ouyang, Z., & Wei, Y. (2019). Effects of CYP2C11 gene knockout on the pharmacokinetics and pharmacodynamics of warfarin in rats. Xenobiotica, 49, 1478-1484.

Zambon, C. F., Pengo, V., Moz, S., Bozzato, D., Fogar, P., Padoan, A., ... & Padrini, R. (2018). Pharmacokinetic and pharmacodynamic re-evaluation of a genetic-guided warfarin trial. Europ J of Clin Pharma, 74, 571-582.

Zayed, A., Babaresh, W. M., Darweesh, R. S., & El-Elimat, T. (2020). Simultaneous determination of warfarin and 7-hydroxywarfarin in rat plasma by HPLC-FLD. Acta Pharmaceutica, 70(3), 343-357.

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