Analysis of paracetamol and caffeine contents in tablet preparations using zero-crossing derivative spectrophotometry method
Article Sidebar
Main Article Content
Page: 323-332
Abstract
The development of drugs in the form of combination tablets at this time has increased a lot; combining drugs in a tablet preparation can provide an increasing reaction and ability. This makes combining drugs such as Paracetamol and caffeine an effective combination in the pharmaceutical field. Paracetamol is an antipyretic analgesic drug that can be combined with caffeine which can be used in therapy with a combination of these drugs. The objective of this research was to ascertain the concentration of a combination of paracetamol and caffeine in a tablet formulation by employing a zero cross-derivative spectrophotometric method. In this study, solvent optimization was carried out with 17 categories of solvent selection, and acetate: methanol (30:70) was selected using the zero cross-derivative methods with a dA / d plot utilizing the maximum wavelength of paracetamol 258 nm and caffeine 288 nm, because there was an actual wavelength shift in this analysis. To validate the determination of the level of the zero cross-derivative method using the second absorption in the ace solvent (30:70 acetate: methanol). Spectrophotometric analysis of zero crossing derivatives of a mixture of paracetamol and caffeine found that paracetamol levels in tablet A were 95.24 8.47%, in tablet B of 92.86 0%, and in tablet C of 96.5 0%, while the caffeine content was 104.89 0%, 102.09 0%, and 91.6 0%. According to USP 30 NF 25 (2007), it can be concluded that the test results of the composition of paracetamol and caffeine in tablets meet the requirements.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
References
Ainil FP., DLP, Effendy & MS, Siti (2018). Simultaneous Spectrophotometric Determination of Paracetamol, Propyphenazone and Caffeine by Using Absorption Ratio Method. Asian Journal of Pharmaceutical Research and Development, Volume 6(5): Hal 5-8 DOI: https://doi.org/10.22270/ajprd.v6i5.412
Nofita, dkk. 2018. Penetapan Kondisi Optimum Pengujian Kadar Paracetamol dan Kafein Dengan Kromatografi Cair Kinerja Tinggi. Jurnal Farmasi Malahayati Vol. 1. No. 2. Program Studi Sarjana Farmasi Universitas Malahayati.
Pulungan, A. F. (2023). Penentuan Kadar Parasetamol Dan Kafein Dalam Sediaan Tablet Menggunakan Metode Spektrofotometri Uv Secara Simple Simultan Equation (Sse). Analit: Analytical And Environmental Chemistry, 8(2), 75–85.
Naid, T., Kasim, M., dan Pakaya, M. (2011). Penetapan Kadar Parasetamol dalam Tablet Kombinasi Parasetamol dengan Kofein secara Spektrofotometri Ultraviolet Sinar Tampak. Makassar: Fakultas Farmasi Universitas Hasanuddin. Majalah Farmasi dan Farmakologi. 15(2): 77 – 82
Maghfiroh, D. dkk. 2022. Pengembangan dan Validasi Metode Spektrofotometri UV-VIS Metode Delivatif Untuk Analisis Kafein Dalam Suplemen. Jurnal Ilmiah Sains & Teknolog. Universitas Ma Chung Malang. DOI: https://doi.org/10.33479/sb.v2i2.151
Liliek, N. 2007. Spektrofotometri Derivatif dan Aplikasinya dalam Bidang Farmasi. Jurnal Ilmu Kefarmasian Indonesia, 5(2):1-9.
Hermita.(2004).Petunjuk Pelaksanaan Validasi Metode dan Cara Perhitungannya. Majalah Ilmu Farmasi hal 117-135. DOI: https://doi.org/10.7454/psr.v1i3.3375
AOAC. 2002. Guaidelines of single laboratory validation of chemica methods for dietary supplements and botanicals. AOAC International, 1-38.
Moffat, A.C., Osselton, M.D., Widdop, B. (2005). Clarke’s Analysis of Drug and Poisons. Fourth Edition. London: Pharmaceutical Press. Halaman 965, 1028, 1173, 1521, 1772, 1988, 2017, 2038 dan 2142.
Shargel, L., Wu-Pong, Susanna & Yu, B.C. Andrew. (2004). Biofarmasetika dan Farmakokinetika Terapan Edisi Kelima. Alih Bahasa: Fasich, Budi Suprapti. Pusat Penerbitan dan Pencetakan Universitas Airlangga: Surabaya
USP 30 NF 25. (2007). The United State Pharmacopoeia 30 and The National Formulary 25. 30th Edition. Halaman 1272.
Pulungan AF. Penentuan kadar parasetamol dan kafein dalam sediaan tablet menggunakan metode spektrofotometri UV secara simple simultan equation (SSE). Analit: Analytical and Environmental Chemistry. 2023 Oct 30:75-85. DOI: https://doi.org/10.23960/aec.v8i2.2023.p75-85
Rosaldi H, Pulungan AF. Penetapan kadar parasetamol dan kafein dalam sediaan tablet menggunakan metode spektrofotometri derivatif zero crossing.
Rosaldi H, Pulungan AF, Ridwanto R, Daulay AS. Simultaneous solubility analysis of paracetamol, propyphenazone, and caffeine using principal component and absorbance ratio regression methods. Indonesian Journal of Science and Pharmacy. 2023 Dec 30;1(2):74-9.
Naid T, Kasim S, Pakaya M. Penetapan kadar parasetamol dalam tablet kombinasi parasetamol dengan kafein secara spektrofotometri ultraviolet sinar tampak. Universitas Hasanuddin. Makassar. 2011 Jul.