Herbal toothpaste formulation of ethanol extract of butterfly pea flower (Clitoria ternatea L.) and antibacterial activity test against Streptococcus mutans bacteria
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Abstract
Dental and oral disease is a disease experienced by almost half of the world's population (3.58 billion people). Gum (periodontal) disease is the 11th most common disease in the world. One of the dental and oral diseases that has a fairly high prevalence in Indonesia is dental caries. The aim of this research was to evaluate the physical quality of toothpaste preparations with various concentrations (10%, 30% and 50%) and to determine the antibacterial activity of ethanol extract toothpaste preparations from butterfly pea flowers (Clitoria ternatea L.) against the growth of Streptococcus mutans bacteria.The stages of this research included processing plant materials, making ethanol extract of butterfly pea with ethanol 96% solvent, characterization examination, screening of phytochemicals, making herbal toothpaste preparations of butterfly pea extract, preparation evaluation, and testing the antibacterial activity of butterfly pea toothpaste against Streptococcus mutans using the well-diffusion method. Based on the research results, it can be seen that the antibacterial activity of the formula with the greatest zones of bacterial inhibition is F1 and F2, namely 21.85 mm and 21.15 mm with very strong inhibition criteria. The conclusion of this study is that herbal toothpaste with butterfly pea extract can prevent and treat dental caries caused by Streptococcus mutans bacteria.
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References
Kusuma AP, Taiyeb AM. Gambaran Kejadian Karies Gigi Pada Anak Kelas 2 Sekolah Dasar Negeri 20 Sungaiselan. Media Kesehat Politek Kesehat Makassar 2020;15:238–44.
i Rakhmawat NS, Budiono I, Rustiana ER. Determinan Perilaku Pemeliharaan Kesehatan Gigi dan Mulut pada Remaja. Pros. Semin. Nas. Pascasarj., vol. 3, 2020, p. 414–9.
Bahar A, Permana HH, Darwita RR, Setiawati F, Ramadhani A, Rahardjo A, et al. Dental Caries Experience and Associated Factors Among 12-year-old Schoolchildren in East Jakarta, Indonesia. J Int Dent Med Res 2021;14:666–70.
Farikha S, Hilmi IL, Salman S. Riview : Pentingnya Penyuluhan Kesehatan Untuk Meningkatkan Pengetahuan Ibu Terkait Imunisasi Pada Anak Anak. J Pharm Sci 2023;6:249–55. https://doi.org/10.36490/journal-jps.com.v6i1.17.
Emilia E. Hubungan Asupan Zat Besi dengan Status Anemia pada Santri Putri di Pondok Pesantren Hidayatussalikin Air Itam Kota Pangkalpinang Tahun 2017. J Kesehat Poltekkes Kemenkes Ri Pangkalpinang 2020;7:64. https://doi.org/10.32922/jkp.v7i2.88.
RI KK. Laporan Nasional Riskesdas 2018 n.d.
Kemenkes RI. Hasil utama RISKESDAS 2018. Jakarta Kemenkes RI 2018.
Widayati N. Faktor yang berhubungan dengan karies gigi pada anak usia 4-6 tahun. J Berk Epidemiol 2014;2:196–205.
Ramayanti S, Purnakarya I. Peran makanan terhadap kejadian karies gigi. J Kesehat Masy Andalas 2013;7:89–93.
Widyastuti W, Fantari HR, Putri VR, Pertiwi I. Formulasi pasta gigi ekstrak kulit jeruk (Citrus sp.) dan daun mint (Mentha piperita L.) serta aktivitas terhadap bakteri Streptococcus mutans. J Pharmascience 2019;6:111–9.
Al-Kholani AI. Comparison between the efficacy of herbal and conventional dentifrices on established gingivitis. Dent Res J (Isfahan) 2011;8:57.
Strassler HE. Toothpaste Ingridients Make a Difference: Patient-Spesific Recommendation. Benco Dent 2013:101–10.
Grossman LI. Ilmu Endodontik Dalam Praktek. 11th ed. Jakarta: EGC; 1995.
Al-Snafi AE. Pharmacological importance of Clitoria ternatea–A review. IOSR J Pharm 2016;6:68–83.
Depkes RI. Farmakope Indonesia Edisi IV. Jakarta: Departemen Kesehatan Republik Indonesia; 1995.
Departemen Kesehatan Republik Indonesia., Depkes RI. Farmakope Hebal Indonesia. Farmakop Herb Indones 2008.
Depkes RI. Farmakope Indonesia edisi VI. 2020.
Depkes RI. Farmakope Indonesia Edisi 3. Edisi 3. Jakarta: Departemen Kesehatan RI; 1979.
ALIFIYA M. Formulasi Dan Uji Stabilitas Fisik Sediaan Krim Tabir Surya Berbahan Aktif Kombinasi Ekstrak Bunga Telang (Clitoria Ternatea) Dan Lidah Buaya (Aloe Vera) 2022.
Ajeng Dwias. Uji Aktivitas Krim Tabir Surya Berbahan Aktif Kombinasi Ekstrak Bunga Telang (Clitoria ternatea) Dan Lidah Buaya (Aloe vera) Secara In Vivo Terhadap Mencit (Mus musculus) 2022.
Raihan GID. Uji Sitotoksisitas Ekstrak Etanol Bunga Telang (Clitoria ternatea L.) Dengan Metode Brine Shrimp Lethality Test (BSLT). J Heal Med Sci 2022:187–202.
Arina M. Optimasi gel ekstrak etanol bunga telang (Clitoria ternatea L) dengan kombinasi HPMC dan karbopol beserta uji aktivitas antioksidan 2020.
Prayoga A, Sumiatin T, Wahyurianto Y. Pengetahuan Tentang Kesehatan Gigi Dan Mulut Siswa DI SDN Sumurgung II. Innov J Soc Sci Res 2024;4:8649–58.
Rijayanti RP, Luliana S, Trianto HF. In vitro antibacterial activity test of ethanol extracts bacang mango (Mangifera foetida L.) leaves against Staphylococcus aureus. Naskah Publ Univ Tanjungpura 2014;1:10–2.
Ningsih DR, Zusfahair DK. Identifikasi Senyawa Metabolit Sekunder Serta Uji Aktivitas Ekstrak Daun Sirsak Sebagai Antibakteri Identification Of Secondary Metabolites Compounds And Antibacterial Activities On The Extract Of Soursop Leaf 2016.
Marjoni R. Dasar-dasar fitokimia untuk diploma III farmasi. Jakarta Trans Info Media 2016.
Astridwiyanti AAB, Mahendra AN, Dewi NWS. Uji efektivitas ekstrak etanol kulit buah naga merah (Hylocereus polyrhizus) terhadap Staphylococcus aureus ATCC 25923 secara in vitro. Intisari Sains Medis 2019;10.
Indonesia DK. Farmakope Indonesia Edisi III. 1979.
Indrawati A, Isnaeni D, Baharuddin S, Luthfiah N. Efektivitas Ekstrak Etanol Daun Turi (Sesbania grandiflora (L.) Pers.) Terhadap Pertumbuhan Pseudomonas aeruginosa dan Staphylococcus aureus. Lumbung Farm J Ilmu Kefarmasian 2022;3:231–40.
Garg, A., D. Aggarwal, S. Garg and AKS. Spreading of Semisolid Formulations, An Update. Pharm Technol 2002;2:84–105.
Doko KI. Uji Aktivitas Antibiofilm terhadap Streptococcus mutans dan Optimasi CMC Na dan Sorbitol pada Formula Pasta Gigi Gel Ekstrak Daun Kelor (Moringa oleifera Lmk.).[Skripsi]. Fak Farm USD, Yogyakarta 2018.
Bangun FO. Pengaruh Peningkatan Konsentrasi Sorbitol dalam Sediaan Pasta Gigi Karbopol yang Mengandung Minyak Kayu Manis (Cinnamomum burmanii).[Skripsi]. Yogyakarta Univ Sanata Dharma 2014.
Novita W. Uji aktivitas antibakteri fraksi daun sirih (Piper Betle L) terhadap pertumbuhan bakteri Streptococcus Mutans secara in vitro. JAMBI Med JOURNAL" J Kedokt Dan Kesehatan" 2016;4.
Alouw G, Fatimawali F, Lebang JS. Uji Aktivitas Antibakteri Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Terhadap Bakteri Staphylococcus aureus Dan Pseudomonas aeruginosa Dengan Metode Difusi Sumuran. J Farm Medica/Pharmacy Med J 2022;5:36–44.