Determination of radical scavenging and sun protection factor of cream preparation contain ethanolic extract of Curcuma longa and Curcuma zedoaria
Article Sidebar
Main Article Content
Page: 240-245
Abstract
Phytochemical studies about Curcuma genus such as Curcuma Longa and Curcuma zedoaria have shown the plants contains curcumin as the most isolated compound shown photoprotection agent and can be formulated as cream preparation. The concentration of Curcuma longa in cream preparation in this reseach was 0,5% and Curcuma zedoaria 0,5; 1; 1,5; 2; 2,5; and 3%. Cream preparations were physical evaluated of semi solid dosage form i.e pH organoleptic, spreadability, homogeneity, adhesion time and viscosity. The result was compared to SNI 16-4399-1996 (Indonesian Standard of UV protection preparation). All formulas were tested for radical scavenging activity using the DPPH method and SPF value determination. The results shown that formulas 3-6 met SNI requirements while formulas 1 and 2 did not met SNI from adhesion testing with results <1 second. Based on the antioxidant test results, it was found that formula 6 had the best antioxidant activity with lowest IC50 value of 126.69 ppm. It was linear as SPF value of formula 6 with 20.24 (ultra category). From this research, it was concluded that the greater of concentration of Curcuma zedoaria extract in cream preparation so free radical scavenger activity was better. Antioxidant activity is related to the SPF value of the preparation.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
References
Anonim. (1996). Standar Nasional Indonesia. Dewan Standardisasi Nasional .
Asriani, N., Zulkarnain, K., Farmasi, F., & Yogyakarta, U. (2023). Stabilitas Fisik dan Aktivitas Krim O/W Ekstrak Etanolik Rimpang Temu Putih [Curcuma zedoaria (Berg.) Roscoe] sebagai Tabir Surya Secara In Vitro. In Jurnal Farmasi IKIFA (Vol. 2, Issue 1).
Ebrahimzadeh, M. A., Enayatifard, R., Khalili, M., Ghaffarloo, M., Saeedi, M., & Charati, J. Y. (2014). Correlation between Sun Protection Factor and Antioxidant Activity, Phenol and Flavonoid Contents of some Medicinal Plants. In Shaheed Beheshti University of Medical Sciences and Health Services Iranian Journal of Pharmaceutical Research (Vol. 13, Issue 3).
Garg, A., Aggarwal, D., Garg, S., & Singla, A. K. (2002). Spreading of Semisolid Formulation. Pharmaceutical Technology, 84–105.
Khartika Membri, D., Yudistira, A., & Sumantri Abdullah, S. (2021). Antioksidan Ekstrak Etanol Spons Liosina paradoxa yang Dikoleksi dari Pulau Mantehage.
Marliani, L., Budiana, W., Anandari, Y., Tinggi, S., & Bandung, F. (2017). The Effect of Extraction Condition on The Polyphenol Content and Antioxidant Activity od Curcuma zedoaria (Christm.) Roschoe Rhizome (Vol. 4, Issue 2).
Sabir, S., Zeb, A., Mahmood, M., Abbas, S., Ahmad, Z., Iqbal, N., & Kashmir, A. (2021). Phytochemical analysis and biological activities of ethanolic extract of Curcuma longa rhizome. Braz. J. Biol, 81(3), 737–740. https://doi.org/10.1590/1519-6984.230628
Setyani, D. A., Rahayu, D. U. C., Handayani, S., & Sugita, P. (2020). Phytochemical and antiacne investigation of Indonesian White Turmeric (Curcuma zedoaria) Rhizomes. IOP Conference Series: Materials Science and Engineering, 902(1). https://doi.org/10.1088/1757-899X/902/1/012066
Yulianti, E., Adelsa, A., & Putri, A. (2015). Penentuan nilai SPF (Sun Protection Factor) Ekstrak Etanol 70 % Temu Mangga (Curcuma mangga) dan Krim Ekstrak Etanol 70 % Temu Mangga (Curcuma mangga) secara In Vitro Menggunakan Metode Spektrofotometri. In Majalah Kesehatan FKUB (Vol. 2, Issue 1).
Zaky, M., Rusdiana, N., & Darmawati, A. (2021). Formulasi dan Evaluasi Fisik Sediaan Gel Antioksidan Ekstrak Etanol 70% Daun Belimbing Wuluh (Averrhoa bilimbi L.) menggunakan Metode DPPH. Jurnal Farmagazine, 8(2), 26. https://doi.org/10.47653/farm.v8i2.556