Topical effects of cinnamon leaf extract (Cinnamomum burmannii) gel as an incision wound healer in male white rabbits (Oryctolagus cuniculus)
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Abstract
Cinnamon leaves (Cinnamomum burmannii) are plants that have many pharmacological effects. One of them is as a wound healer. The gel formulation becomes a convenient therapeutic solution for use. This study aimed to determine the impact of gel preparations on the healing of incision wounds in male white rabbits. The research method uses experimental methods. The test animal was injured on its back using a tool with a diameter of 2.5cm. There are five treatment groups used, namely: positive control (Bioplasenton), negative control (gel base), Formula 1 (extract 2.5%), Formula 2 (extract 5%), and Formula 3 (extract 7.5%). The results of wound healing observations were analysed using one-way ANOVA with a confidence level of 95%. The results showed that the best formula for wound healing is formula 2. Then, formula three and formula 1 had a significance value between groups of 0.05.
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References
Pratama AB. Khasiat Tanaman Obat Herbal. 2021.
Atmojo M, Darumurti A. Pemberdayaan Masyarakat Melalui Tanaman Obat Keluarga (TOGA). Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat. 2021;4(1). DOI: https://doi.org/10.31294/jabdimas.v4i1.8660
Ramadhani Yuni et. al. Kosep Dasar Luka. Vol. 1, DMM Disease Models and Mechanisms. 2021.
Ariningrum D, Subandono J. Buku Pedoman Manajemen Luka. Fakultas Kedokteran Universitas Sebelas Maret Surakarta. 2018;
Anggowarsito JL. Luka Bakar Sudut Pandang Dermatologi. Jurnal Widya Medika. 2014;2(2).
Sani K., F, Afrilia N, Utami DT, Yuliawati Y. In Vivo, Incision Wound Healing Studies using Ethanolic Cinnamon’s (Cinnamomum burmannii) Leaves Extract in White Male Rats. Jurnal Ilmu Kefarmasian Indonesia. 2022;20(2). DOI: https://doi.org/10.35814/jifi.v20i2.1239
Astika, Rahmila Yuni, Sani K. Fathnur E. Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Kayu Manis (Cinnamomum burmannii) pada Mencit Putih Jantan. 2021;8(1):105–12.
Maulina L, Sugihartini N. Formulasi Gel Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L.) Dengan Variasi Gelling Agent sebagai Sediaan Luka Bakar. Pharmaciana. 2015;5(1). DOI: https://doi.org/10.12928/pharmaciana.v5i1.2285
Zamil ST, Zamil ST, Naser NA, Kadhim HA. Formulation and Evaluation of Topical Formula Gel for Dermatitis and Inflammations. International Journal of Drug Delivery Technology. 2022;12(2). DOI: https://doi.org/10.25258/ijddt.12.2.62
Sugihartini* N, Jannah S, Yuwono T. Formulasi Gel Ekstrak Daun Kelor (Moringa oleifera Lamk) Sebagai Sediaan Antiinflamasi. Pharmaceutical Sciences and Research. 2020;7(1):9–16. DOI: https://doi.org/10.7454/psr.v7i1.1065
Rokhmah NN, Yulianita Y, Putra RA. Efektivitas Gel Daun Pandan Wangi Sebagai Obat Luka Bakar Pada Tikus Putih Jantan. Pharmacoscript. 2021;4(2). DOI: https://doi.org/10.36423/pharmacoscript.v4i2.595
Fathnur Sani K, Agung Giri S, Enda Oktri M. Formulasi Dan Uji Aktivitas Gel Lendir Belut (Monopterus albus) Sebagai Penyembuh Luka Bakar. Jurnal Ilmiah Ibnu Sina, Vol 3, Iss 2, Pp 186-194 (2018). 2018;
Nurhasnawati H, Sukarmi, Handayani F. Perbandingan Metode Ekstraksi Maserati dan Sokletasi Terhadap Aktivitas Antioksidan Ekstrak Etanol Daun Jambu Bol (Syzygium malaccense L.). Jurnal Ilmiah Manuntung. 2017;3 (1):91–5. DOI: https://doi.org/10.51352/jim.v3i1.96
Nursofia Y., SaniK F, Yuliawati. Uji Toksisitas Akut Ekstrak Etanol Daun Kayu Manis (Cinnamomum burmanii) Pada Fungsi Hati Tikus Putih(Mus musculus L.) Betina. Jurnal Ilmiah Ibnu Sina [Internet]. 2021;6(1):133–42. Available from: http://e-jurnal.stikes-isfi.ac.id/index.php/JIIS/article/view/720/509 DOI: https://doi.org/10.36387/jiis.v6i2.720
Oryan A, Mohammadalipour A, Moshiri A, Tabandeh MR. Topical application of aloe vera accelerated wound healing, modelling, and remodelling. Ann Plast Surg. 2016;77(1):37–46. DOI: https://doi.org/10.1097/SAP.0000000000000239
Sani K F, Samudra AG, Rahman H, Rahman AO. Efektivitas Khasiat Penyembuhan Luka Sayat Gel Ekstrak Etanol Daun Ekor Naga ( Rhaphidophora pinnata ( L . f ) Schott ) Berdasarkan Analisis Hidroksiprolin Effectiveness of Incision Wound Healing of Extract Ekor Naga. Jurnal Farmasi Sains dan Terapan [Internet]. 2022;9(2):60–6. Available from: http://journal.wima.ac.id/index.php/JFST/article/view/4084/3172 DOI: https://doi.org/10.33508/jfst.v9i2.4084
Anatasya B, Sanik F, Muhaimin M. Topical anti-inflammatory effect of Ekor Naga (Rhaphidophora pinnata (L.f) Schott) leaves extract. Pharmaciana. 2021;11(3):303. DOI: https://doi.org/10.12928/pharmaciana.v11i3.17617
Astika RY, Sani F, Elisma. Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Kayu Manis (Cinnamomum burmanni) Pada Mencit Putih Jantan. Jurnal Ilmiah Manuntung. 2022;8(1):14–23. DOI: https://doi.org/10.51352/jim.v8i1.465