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Dwi Dominica
Saskia Anisah
Risky Hadi Wibowo
Fahma Shufyani

Abstract

Background: Formulation is an activity to design the composition of the active ingredients and additional ingredients to make specific preparations. One of the herbal plants that can be formulated in hand and body lotion is binahong leaves (Anredera cordifolia (Ten.) Steenis), which contain secondary metabolites such as flavonoids, saponins, alkaloids, and tannins. These secondary metabolites function as antibacterials. Gram-positive bacteria often cause skin problems, such as Staphylococcus aureus. This study aimed to determine the antibacterial activity of 5%, 7.5%, 10%, 12.5%, and 15% binahong leaf extract hand and body lotion against S. aureus bacteria. This research was conducted experimentally, including an examination of the physical quality of the preparation (organoleptic, homogeneity, pH, spreadability, and adhesion). This Method research is an experimental study, including collecting samples, making kepok banana heart calyx juice with concentrations of 2%, 4% and 6%, ointment evaluation tests and cut wound healing activity tests on white mice which were grouped into five groups with each group consisting of of 5 mice. Statistical analysis included a one-way ANOVA test to see whether there was a significant difference between concentrations and wound healing in white male mice. The results showed that binahong leaf extract could be formulated into hand and body lotion preparations because it has a homogeneous composition, a pH range of 4.8-5.1, spreadability of 5.7-6.0 cm, and adhesion of 2.16-2.49 seconds. Hand and body lotion preparations with 10% binahong leaf extract have the best physical quality. All formulations of binahong leaf extract hand and body lotion in this study could inhibit the growth of S. aureus with weak inhibition, and the best formula for inhibiting the growth of S. aureus was 15% binahong leaf extract hand and body lotion having a diameter of inhibition zone 2.575 m.


 

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How to Cite
Dominica, D., Anisah, S., Wibowo, R. H., & Shufyani, F. (2023). Antibacterial activity of hand and body lotion preparations from ethanol extract of binahong leaves (Anredera cordifolia (Ten.) Steenis) against Staphylococcus aureus bacteria . Journal of Pharmaceutical and Sciences, 6(5-si), 215–224. https://doi.org/10.36490/journal-jps.com.v6i5-si.405
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Original Articles

References

Amalia A, Sari I, dan Nursanty I. (2018). Aktivitas Antibakteri Ekstrak Etil Asetat Daun Sembung (Blumea balsamifera (L.) DC.) Terhadap Pertumbuhan Bakteri Methicillin Resistant Staphylococcus aureus (MRSA). Seminar Nasional Biotik, 5 (1): 387–391.

Ba’tsah, R., Wirasti, W., & Fitriyani, F. (2021). Uji Formulasi dan Uji Efektivitas Repelan Lotion Ekstrak Daun Tembakau (Nicotiana tabacum. L) terhadap Nyamuk Aedes Aegypti. In Prosiding Seminar Nasional Kesehatan (1): 1968-1976.

Departemen Kesehatan RI. 2000. Parameter Standar Umum Ekstrak Tumbuhan Obat, Cetakan Pertama. Jakarta: Direktorat Jenderal Pengawasan Obat dan Makanan.

Dominica, D., & Handayani, D. (2019). Formulasi dan Evaluasi Sediaan Lotion dari Ekstrak Daun Lengkeng (Dimocarpus Longan) sebagai Antioksidan. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 6 (1): 1-7.

Dwicahyani, T., Sumardianto, S., & Rianingsih, L. (2018). Uji Bioaktivitas Ekstrak Teripang Keling Holothuria atra sebagai Antibakteri Staphylococcus aureus dan Escherichia coli. Jurnal Pengolahan dan Bioteknologi Hasil Perikanan, 7 (1): 15-24.

Febrianti, R. (2021). Fraksinasi dan Skrining Fraksi Ekstrak Etanol Daun Binahong (Anredera cordifolia (Ten) Steenis) dengan Menggunakan Metode Kromatografi Lapis Tipis (Disertasi doktoral, Stikes Al-Fatah Bengkulu).

Garg, A., Aggarwal, D., Garg, S., & Singla, A. K. (2002). Spreading of Semisolid Formulations: An Update. Pharmaceutical Technology of North America, 26 (9): 84-105.

Hidayati, N., & Khaerunisa, D. (2018). Pengaruh Jenis Pelarut pada Pengambilan Minyak Atsiri Daun Kelor dengan Metode Ultrasonic Assisted Extraction. Simposium Nasional Universitas Muhammadiyah Surakarta, 17: 119-123.

Karim, N., Arisanty., & Pakadang, S. R. (2022). Formulasi dan Uji Stabilitas Sediaan Lotion Ekstrak Air Buah Tomat (Solanum lycopersicum L.). Jurnal Kefarmasian Akfarindo, 7 (2): 100-107.

Larissa, U., Wulan, A. J., & Prabowo, A. Y. (2017). Pengaruh Binahong terhadap Luka Bakar Derajat II. Jurnal Majority, 7 (1): 130-134.

Lay, B. W. (1994). Analisis Mikroba di Laboratorium. Jakarta: PT. Raja Grafindo.

Mardikasari, S.A., Mallarangeng, A. N. T. A., Zubaydah, W. O. S., Juswita, E. (2017). Formulasi Dan Uji Stabilitas Lotion dari Ekstrak Etanol Daun Jambu Biji (Psidium Guajava L.) Sebagai Antioksidan. Jurnal Farmasi Sains Dan Kesehatan. 3 (2): 28-32.

Ningrum, W. A., Wirasti, W., Permadi, Y. W., & Himmah, F. F. (2021). Uji Sediaan Lotion Nanopartikel Ekstrak Terong Belanda Sebagai Antioksidan. Jurnal Ilmiah Kesehatan, 14 (1): 99-104.

Novianti, T., Wijayanti, I., & Setyowati, E. (2019). The Potential of Binahong (Anredera cordifolia (Ten.) Steenis) Leaves Extract as Natural Antioxidant and Its Characterization. IOP Conference Series: Earth and Environmental Science, 251 (1): 90-99.

Oktaviasari, L & Zulkarnain, A. K. (2021). Formulation and Physical Stability Test of Lotion O/W Potato Starch (Solanum tuberosum L.) and the Activities as Sunscreen. Majalah Farmaseutik, 13 (1): 9-27.

Olaniyan, L. W. B., Mkwetshana, N., dan Okoh, A.I. (2016). Triclosan in Water, Implications for Human and Environmental Health. Springer Plus, 5 (1639): 10-11.

Patil, A., Bhide, S., Bookwala, M., Soneta, B., Shankar, V., Almotairy, A., ... & Narasimha Murthy, S. (2018). Stability of Organoleptic Agents in Pharmaceuticals and Cosmetics. American Association of Pharmaceutical Scientist, 19 (1): 36-47.

Saputra, S. A., Lailiyah, M., & Atika, S. T. R. (2020). Formulasi Gel Pewarna Rambut dari Sari Daun Tarum (Indigofera Tinctoria L.) dengan Basis Carbopol 940. In Prosiding Seminar Hasil Penelitian.

Sari, D. K., & Lestari, R. S. D. (2015). Pengaruh Waktu dan Kecepatan Pengadukan Terhadap Emulsi Minyak Biji Matahari (Helianthus annuus L.) dan Air. Jurnal Integrasi Proses, 5 (3): 155-159.

Surbakti, P. A. A. (2018). Skrining Fitokimia dan Uji Toksisitas Ekstrak Etanol Daun Binahong (Andredera cordifolia (Ten.) Steenis) dengan Metode Brine Shrimp Lethality Test (BSLT). Pharmacon, 7 (3): 551-560.

Tari, M., Alta, U., dan Indriani, O. (2022). Penetapan Kadar Flavonoid Secara Spektrofotometri Visibel pada Daun Jambu Biji dengan Perbedaan Suhu Pengeringan Simplisia. Jurnal Aisyiyah Medika, 7 (1): 89-101.

Usman, Y. (2022). Formulasi dan Uji Stabilitas Hand Body Lotion dari Ekstrak Etanol Rumput Laut (Eucheuma cottonii). Journal Syifa Sciences and Clinical Research, 4 (1): 18-26.

Utami, H. F., Hastuti, R. B., & Hastuti, E. D. (2015). Kualitas Daun Binahong (Anredera cordifolia) pada Suhu Pengeringan Berbeda. Jurnal Akademika Biologi, 4 (2): 51-59.

Waluyo, L. (2008). Teknik dan metode dasar dalam mikrobiologi. Malang: Universitas Muhammadiyah Malang Press.

Wasitaatmadja, S. M. (1997). Penuntun Ilmu Kosmetik Medik. Jakarta: Universitas Indonesia Press.

Yonguep, E., Fabrice, K. K., Katende, J. K., & Chowdhury, M. (2022). Formation, Stabilization and Chemical Demulsification of Crude Oil-in-water Emulsions: A review. Petroleum Research, 7 (1): 459-472.

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