Standardization of Diosgenin Compounds in Plants: Review Article
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Abstract
Diosgenin is a steroid sapogenin composed of a hydrophilic sugar with a hydrophobic steroid aglycone which functions as a starting material in the production of steroid drugs and hormones. Pharmacologically, diosgenin has been widely used as a treatment for leukemia, inflammation, hypercholesterolemia, and cancer. Diosgenin compounds are contained in plants such as abutilon indicum L, Coctus speciosus, tubers of Dioscorea spp, and fenugreek seeds. In order to guarantee the quality of the product, the active compounds must be standardized, so that uniform raw materials can be obtained and the pharmacological effects of these plants can be guaranteed. This article review was carried out by means of literature studies using secondary data in the form of journals and articles to standardize diosgenin compounds in several plants using high performance liquid chromatography (HPLC), high performance thin layer chromatography (HPTLC), ultra high performance liquid chromatography (UPLC) methods. and thin layer chromatography (TLC).
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References
Anam, S., Yusran, M., Trisakti, A., Ibrahim, N., Khumaidi, A., & Sulaiman Zubair, M. (2013). Standarisasi Ekstrak Etil Asetat Kayu Sanrego (Lunasia amara Blanco). Online Jurnal of Natural Science, 2(3), 1–8.
Burda, N. Y., Zhuravel, I. O., Dababneh, M. F., & Fedchenkova, Y. A. (2019). Analysis of diosgenin and phenol compounds in Tribulus terrestris L. Pharmacia, 66(2), 41–44. https://doi.org/10.3897/pharmacia.66.e35023
Candani, D., Ulfah, M., Noviana, W., & Zainul, R. (2018). A Review Pemanfaatan Teknologi Sonikasi. INA-Rxiv, 26, 1–9.
Król-Kogus, B., Lamine, K. M., Migas, P., Boudjeniba, M., & Krauze-Baranowska, M. (2018). HPTLC determination of diosgenin in fenugreek seeds. Acta Pharmaceutica, 68(1), 97–107. https://doi.org/10.2478/acph-2018-0002
Lumbanraja, I. M., Wartini, N. M., & Suhendra, L. (2019). Pengaruh Jenis Pelarut dan Ukuran Partikel Bahan terhadap Karakteristik Ekstrak Daun Bidara (Ziziphus mauritiana L.) sebagai Sumber Saponin. Jurnal Rekayasa Dan Manajemen Agroindustri, 7(4), 541. https://doi.org/10.24843/jrma.2019.v07.i04.p06
Nainggolan, M., Ahmad, S., Pertiwi, D., & Nugraha, S. E. (2019). Penuntun Dan Laporan Praktikum Fitokimia. Universitas Sumatera Utara, 1–58. https://ffar.usu.ac.id/images/Buku_Penuntun_Laboratorium/Penuntun-Fitokimia-S-1.pdf
Nasution Anggi Dina Mora, Ulil Amna, H. (2019). Skrining Fitokimia Daun Jarak Pagar ( Jatropha curcas L .). Quimica: Jurnal Kimia Sains dan Terapan, 1(1).
Nazir, R., Pandey, D. K., Pandey, B., Kumar, V., Dwivedi, P., Khampariya, A., Dey, A., & Malik, T. (2021). Optimization Of Diosgenin Extraction From Dioscorea deltoidea Tubers Using Response Surface Methodology And Artificial Neural Network Modelling. PLoS ONE, 16(July), 1–19. https://doi.org/10.1371/journal.pone.0253617
Prabowo, A. Y., Teti, E., & Indria, P. (2014). Gembili (Dioscorea esculenta L.) as Food Contain Bioactive Compounds: A Review. Jurnal Pangan dan Agroindustri, 2(3), 129–135.
Putra Jatmiko, G., Estiasih, T., Kunci: Gluten, K., Kimpul, M., Bioaktif, S., Kimpul, T., & Kimpul, U. (2014). MIE DARI UMBI KIMPUL (Xanthosoma Sagittifolium): KAJIAN PUSTAKA Noodles From Cocoyam (Xanthosoma Sagittifolium): A Review. Jurnal Pangan dan Agroindustri, 2(2), 127134.
Rahma, A., Taufiqurrahman, I., & Edyson. (2017). Perbedaan Total Flavonoid Antara Metode Maserasi Dengan Sokletasi Pada Ekstrak Daun Ramania (Bouea macrophylla Griff). Dentino jurnal kedokteran gigi, 1(1), 22–27.
Ruma, M. T. L., Nono, K. M., Bura, L. Y., Studi, P., & Fst, B. (2021). Antibakteri Ekstrak Akar Dan Daun Kembang Sore ( Abutilon Indicum L .) Terhadap Pertumbuhan Escherichia Coli. 18(2), 59–65.
Singh, R., Kharat, S. N., & Mendhulkar, V. D. (2016). Chromatographic analysis for “diosgenin” content in Abutilon indicum (L) sweet. International Journal of Pharmacy and Pharmaceutical Sciences, 8(2), 178–182.
Suharto, M. A. P., Edy, H. J., & Dumanauw, J. M. (2012). Isolasi Dan Identifikasi Senyawa Saponin Dari Ekstrak Metanol Batang Pisang Ambon(Musa paradisiaca var. sapientum L.). pharmacon, 1(2), 86–92.
Susanti, H., Wahyuono, S., Susidarti, R. A., & Sari, I. P. (2017). Penetapan Kadar Diosgenin Dalam Ekstrak Air Costus Speciosus Secara HPLC. Majalah Obat Tradisional, 22(1), 1. https://doi.org/10.22146/tradmedj.24171