Testing the effectiveness of senggani (Melastoma malabathricum L.) leaf ethanol extract as antihypertension in male white mouse (Mus musculus)
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Abstract
Background; Senggani leaves have secondary metabolites that can inhibit the release of aldosterone so that more water is removed from the body and blood pressure will drop. Objectives; The purpose of this study was to determine the effectiveness of the ethanol extract of senggani leaves (Melastoma malabathricum L.) on reducing blood pressure of male white mice (Mus musculus). Method; this research is experimental which includes sampling, sample processing, extract making, simplicia characteristics, preparation of test materials, treatment of test animals and data analysis. The samples used were senggani leaves (Melastoma malabathircum L.). The test animals used were 15 male white mice then divided into 5 groups. Measurement of blood pressure using a blood pressure analyzer with the tail cuff method. The measurement data were then analyzed using a paired t-test with a significance limit of 0.05. Result; showed that the ethanol extract of senggani leaves had antihypertensive effectiveness with the lowest systolic blood pressure measurement results after treatment at EEDS 150 mg/kgBW which was 86.66 mmHg and diastolic blood pressure obtained the lowest after treatment at EEDS 150 mg/KgBW, which was 59 mmHg. . The results of the statistical paired t-test showed that there was an effect of giving the test material EEDS 50 mg/kgBW, EEDS 100 mg/kgBW, EEDS 150 mg/kgBW test for 14 days with p-value <0.05. On diastolic blood pressure, the effect of treatment with the test material on blood pressure was significant at EEDS 150 mg/kgBW with p-value = 0.001. Conclusion; this study was that the administration of the ethanol extract of the leaves of senggani (Melastoma malabathricum L.) could reduce the blood pressure of experimental male mice (Mus musculus). The ethanol extract of senggani leaves (Melastoma malabathricum L.) was effective in lowering blood pressure at a dose of 150 mg.
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References
Almatsier. (2001). Prinsip Dasar Ilmu Gizi. Jakarta: Gramedia Pustaka Utama.
American Medical Assosiation. (2014). Evidence Based Guideline for the Management of High Blood Pressure in adults: Eight Joint National Committee (JNC 8). JAMA, 311(5).
Andry, M., Faisal, H., & Apila, N. N. (2022). Formulasi dan Uji Aktivitas Antioksidan Sediaan Krim Ekstrak Etanol Daun Asam Jawa (Tamarindus indica L.) dengan Menggunakan Metode DPPH. Jurnal Dunia Farmasi, 6(2), 96–107.
Appel LJ, Brands MW, D. S. (2006). Dietary Approaches to prevent and Treat Hypertension A Scientific Statement From the American Heart Association. Hypertension, 47, 296–308.
Awwaliyah, R., Muslikh, F. A., Abada, I., Megawati, D. S., & Ibrahim, M. (2023). Aktivitas Penyembuhan Luka Formulasi Salep Ekstrak Etanol Daun Kitolod (Isotoma longiflora) Pada Mencit (Mus musculus). Jurnal Dunia Farmasi, 7(2), 105–115.
Ayu, P., Pebriyanti, N., Ngurah, I. G., Windra, A., Putra, W., & Sutjana, I. D. P. (2023). Aktivitas Kombinasi Ekstrak Etanol Daun Salam (Syzygium polyanthum) dan Daun Gambir (Uncaria Gambir) Terhadap Penurunan Glukosa Darah Tikus (Rattus norvegicus ). Jurnal Dunia Farmasi, 7(2), 91–104.
Dalimartha S. (2000). Atlas Tumbuhan Obat Tradisional. Trobus Agriwidya.
Departemen Kesehatan RI. (2010). Hipertensi Penyebab Kematian.
Handayany, G. N. dan M. (2010). Buku Dirasah Farmakologi II. Makasar. Alauddin Press.
Kaplan’s. (2010). Hypertension in the Population at Large.
Lubis, A. A., Yunus, M., Naldi, J., Andry, M., Ginting, P., Safitri, F., & Nasution, M. A. (2023). Antihyperuricemia activity test of kopasanda leaf extract (Chromolaena Odorata (L.) R.M.King &; H.Rob against male white mice (Mus Musculus L.) induced potassium oxonate. Journal of Pharmaceutical and Sciences, 6(3), 1273–1281.
Merryaria KA. (2010). Kajian Kergaman Tumbuhan Hutan Berkhasiat Obat Berdasarkan Etnobotani dan Fitokimia di Taman Nasional Lore Lindu. Balai Penelitian Kehutanan Makkasar.
Oparil S, Zaman A, C. DA. (2003). Pathogenesis of Hypertension. Ann Intern Med, 139, 761.
Rahayu M, Sunarti S, Sulistiarni D, P. S. (2006). Kajian Pemanfaatan Tumbuhan Sebagai Obat Tradisional Oleh Masyarakat lokal di Keacamatan Wowanii Pulau Wowanii Sulawesi Tenggara. Biodiversitas, 7(3).
Ramlah, Pratiwi, L., & Nurbaeti, S. N. (2019). Qualitative Test of Flavonoid Compound Ethyl Acetate Extract of Senggani Leaf (Melastoma malabathricum L.). Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN, 4(1), 1–4.
Roza A. (2016). Hubungan gaya hidup dengan kejadian hipertensi di Puskesmas Dumai Timur Dumai – Riau. Kesehatan STIKes Prima Nusantara Bukittinggi. 7(1), 47–52.
Tabassum N dan Ahmad F. (2011). Role of natural herbs in the treatment of hypertension. Pharmacogn Rev, 5(9), 30–40.
Winata, H. S., Faisal, H., Andry, M., Aulia, N., Nasution, M. A., & Tambunan, I. J. (2023). Determination of total flavonoid content of ethanolic extract of yellow mangosteen (Garcinia xanthochymus) by spectrometry Uv-Vis method and LCMS. Journal of Pharmaceutical and Sciences, 6(3), 935–950.
Yunus, M., Naldi, J., & Andry, M. (2023). Diuretic activity test of red betel leaf ethanol extract (Piper crocatum Ruiz & Pav) against male white rats (Rattus novergicus). Journal of Pharmaceutical and Sciences, 6(3), 1161–1169.