Antihyperuricemia activity test of kopasanda leaf extract (Chromolaena Odorata (L.) R.M.King &; H.Rob against male white mice (Mus Musculus L.) induced potassium oxonate
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Abstract
Background: Kopasanda leaves (Chromolaena Odorata (L.) R.M.King & H.Rob have been known as medicinal plants and spread in North America, Asia, West Africa and Australia have antibacterial and antioxidant properties, because the active compounds contained in Kopasanda leaves include: alkaloids, flavonoids, steroids, quinone saponins, and tannins. Purpose; This study was to determine the activity of ethanol extract of kopasanda leaves (Chormolaena Odorata (L.) in reducing uric acid levels and to test antihyperuricemia levels and phytochemical screening. Method; This study used a laboratory experimental research design, to extract the chemical content in kopasanda leaves using maceration method using 70% ethanol. This research includes sampling, simplisia making, extract making, phytokimi screening, suspension making, test animal preparation and antihyperuricemia testing. The research data were analyzed using the crucible wallis test statistical test. Result; The study showed a decrease in uric acid levels in the EEDK group 20 mg / BB = 0.86%, EEDK 40 mg / BB = 1.18% and EEDK 80 mg / BB = 2.3%. The results of Wallis' crucial statistical test on day 9 showed a significant difference with a p-value of 0.000. The results of further difference tests showed a significant difference in each treatment. Conclusion: in this study is the ethanol extract of kopasanda leaves (Chromolaena Odorata (L), R.M.King &; H. Rob) the most effective is 80 mg / BB, this is evidenced by the results of one way anova statistical test with a p-value of 0.000 (<0.05).
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References
Amir, M., & Purukan, J. I. A. (2018). Uji Efektifitas Ekstras Etanol Buah Naga Putih (Hylocereus undatus) Terhadap Penurunan Kadar Asam Urat Darah Pada Mencit (Mus musculus). Jurnal Ilmu Kefarmasian Indonesia, 16(2), 166. https://doi.org/10.35814/jifi.v16i2.536
Andry, M., Faisal, H., & Apila, N. N. (2022). Formulasi dan Uji Aktivitas Antioksidan Sediaan Krim Ekstrak Etanol Daun Asam Jawa (Tamarindus indica L.) dengan Menggunakan Metode DPPH. Jurnal Dunia Farmasi, 6(2), 96–107.
Andry, M., & Winata, H. S. (2022). Uji Aktivitas Antibakteri Streptococcus Mutans serta Formulasi Sediaan Pasta Gigi Ekstrak Etanol Buah Okra Hijau (Abelmoschus esculentus) dan Tulang Ikan Tuna (Thunnini). Journal of Pharmaceutical and Sciences (JPS), 5(2), 170–173.
Cendrianti, F., Muslichah, S., & Ulfa, E. U. (2014). Uji Aktivitas Antihiperurisemia Ekstrak n-Heksana , Etil Asetat , dan Etanol 70 % Daun Tempuyung ( Sonchus arvensis L .) pada Mencit Jantan Hiperurisemia. E-Jurnal Pustaka Kesehatan, 2(2), 205–207.
Fitrah, M. (2016). Identifikasi Ekstrak Daun Kopasanda (Chromolaena odorada Linn) terhadap Sel Antiproliferasi Tikus Leukemia L1210. Jf Fik Uinam, 4(3), 99–105.
Fitri, K., Khairani, T. N., Andry, M., Rizka, N., & Nasution, M. A. (2023). Activity Test of Anti-acne Cream of Lotus Leaves (Nelumbo nucifera g.) Ethanol Extract on Bacteria of Propionibacterium Acnes and Staphylococcus aureus. Journal Pharmaceutical and Sciences, 6(1), 37–45.
Hasibuan, Chairani, D., & Angraini, S. F. (2020). Jurnal Kesehatan Ilmiah Indonesia ( Indonesian Health Scientific Journal ) Efektifitas Rebusan Daun Sirsak Terhadap Penurunan Skala Nyeri Pada Penderita Gout Arthritis Devi Chairani Hasibuan , Febrina Angraini Simamora Dosen Prodi Keperawatan Universitas. Indonesian Health Scientific Journal, 5(2), 74–80.
Hendra Stevani, S.Si., M.Kes., A. (2016). Praktikum Farmakologi Koprehensif. 171.
Isa Desi Mawati. (2017). Uji Aktivitas Antihiperurisemia Ekstrak Etil Asetat Tanaman Suruhan (Peperomia pellucida L. Kunth) Pada Tikus Putih Jantan Yang Diinduksi Kafein. UIN Syarif Hidayatullah, Jakarta, 1–64.
Juwita, R., Saleh, C., & Sitorus, S. (2017). Uji Aktivitas Antihiperurisemia dari Daun Hijau Tanaman Pucuk Merah ( Syzygium myrtifolium Walp.) terhadap Mencit Jantan (Mus musculus) Antihyperuricemia Activity Test from Green Leaf of Plant Red Bud (Syzygium myrtifolium walp.) to Male Mice (Mus mus. Jurnal Atomik, 2(1), 162–168.
K. Fitri, M. Andry, Khairani, T. N., Winata, H. S., A. Violenta, N. Lubis, & Lubis, M. F. (2023). Synthesis of Silver Nanoparticles Using Ethanolic Extract of Nelumbo nucifera Gaertn. Leaf and Its Cytotoxic Activity Against T47D and 4T1 Cell Lines. Rasayan Journal of Chemistrymistry, 16(01), 104–110. https://doi.org/10.31788/rjc.2023.1618000
Kartikawati, E., Deswati, D. A., & Pramudita, B. (2020). Uji efek analgetik ekstrak etanol daun asam jawa (Tamarindus indica L.) pada mencit putih jantan galur swiss webster. Jurnal Sabdariffarma, 1(2), 11–18.
Latief, M., Tarigan, I. L., Sari, P. M., & Aurora, F. E. (2021). Aktivitas Antihiperurisemia Ekstrak Etanol Daun Sungkai (Peronema canescens Jack) Pada Mencit Putih Jantan. Pharmacon: Jurnal Farmasi Indonesia, 18(1), 23–37. https://doi.org/10.23917/pharmacon.v18i01.12880
Leobernard Butue, Fatimawali, & Wewengkang, D. S. (2019). Pharmacon – Program Studi Farmasi, FMIPA, Universitas Sam Ratulangi. 8(November), 671–678.
Mus, S., Rahimah, S., Taebe, B., Muslimin, L., Tinggi, S., & Farmasi Makassar, I. (2020). Acute Toxicity Test of Kopasanda (Chromolaena odorata L) Leaves Ethanol Extract Using Brine Shrimp Lethality Test (BSLT) Method. Journal of Pharmaceutical and Medicinal Sciences, 5(2), 44–47.
Nuari, D. A., Renggana, H., Yuniar, C. T., Novitasari, M., & Lulu, A. (2021). Aktivitas Antihiperurisemia Ekstrak Etanol Daun Afrika (Vernonia amygdalina Delile.) pada Mencit Putih Galur Swiss Webster yang Diinduksi Melinjo dan Hati Ayam. Pharmacon: Jurnal Farmasi Indonesia, 18(1), 89–96. https://doi.org/10.23917/pharmacon.v18i01.12318
Nurhajanah, M., Agussalim, L., Iman, S. Z., & Hajiriah, T. L. (2020). Analisis Kandungan Antiseptik Daun Kopasanda (Choromolaena odorata) sebagai Dasar Pembuatan Gel pada Luka. Bioscientist : Jurnal Ilmiah Biologi, 8(2), 284. https://doi.org/10.33394/bjib.v8i2.2886
Rochmawati, D. (2019). Uji Efektivitas Diuretik Ekstrak Bunga Rosella (Hibiscus sabdariffaL.) Terhadap Mencit Jantan (Mus musculus). 7–8.
Singgih, S. (2020). Panduan Lengkap SPSS 26. Jakarta: PT Alex Media Komputindo.
Sonia, R., Yusnelti, Y., & Fitrianingsih, F. (2020). Efektivitas Ekstrak Etanol Daun Durian (Durio zibethinus (Linn.)) sebagai Antihiperurisemia. Jurnal Kefarmasian Indonesia, 10(2), 130–139. https://doi.org/10.22435/jki.v10i2.2148
Suntara, D. A. (2022). Hubungan Antara Aktifitas Fisik dengan Kadar Asam Urat (GOUT) Pada Lansia di Wilayah Kerja Puskesmas Batu Aji Kota Batam. Jurnal Inovasi Penelitian, 2(2), 613–622.
Telly Pratiwi, S., Riska, A., & Ratwita, W. (2019). Efek Diuretik Ekstrak Etanol Daun Putri Malu (Mimosa pudica L.) Dibandingkan Dengan Hidroklorotiazid Pada Kelinci (Lepus negricollis) Jantan. Medika Kartika Jurnal Kedokteran Dan Kesehatan, 2(Volume 2 No 2), 88–97. https://doi.org/10.35990/mk.v2n2.p88-97
Winata, H. S., Andry, M., Nasution, M. A., Rezaldi, F., & Sembiring, A. S. F. B. (2023). Anti-Inflammatory Activity of Stem Barks Ethanol Extracts of Asam Kandis On Male White Rats. Journal of Agromedicine and Medical Sciences, 9(1), 47–53.