Identifikasi Glibenklamid Pada Jamu Kencing Manis Yang Beredar di Medan Johor
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Latar Belakang: Meningkatnya penggunaan jamu antidiabetes di masyarakat diiringi dengan maraknya praktik pemalsuan dengan penambahan obat sintetik seperti glibenklamid (C₂₃H₂₈ClN₃O₅S) untuk meningkatkan khasiat dan penjualan. Hal ini berpotensi menimbulkan risiko kesehatan, sehingga perlu dilakukan pengawasan ketat terhadap produk jamu yang beredar. Tujuan: Penelitian ini bertujuan untuk mengidentifikasi keberadaan glibenklamid dalam tiga sampel jamu antidiabetes yang beredar di Medan Johor menggunakan Fourier-Transform Infrared Spectroscopy (FTIR). Metode: Identifikasi dilakukan dengan membandingkan spektrum FTIR sampel (bilangan gelombang 650-4000 cm⁻¹) terhadap standar glibenklamid BPFI. Gugus fungsi khas glibenklamid yang menjadi acuan adalah 3369,5 cm⁻¹ (Amida N-H Stretching), 1714,6 cm⁻¹ (C=O Stretching), dan 1155,5 cm⁻¹ (S=O Stretching). Hasil Penelitian: Hasil analisis menunjukkan bahwa ketiga sampel (A2, A3, A4) tidak mengandung puncak serapan karakteristik glibenklamid pada bilangan gelombang kritis tersebut. Dengan demikian, sampel yang diuji dinyatakan bebas dari bahan kimia obat (BKO) glibenklamid. Kesimpulan: Temuan ini mengindikasikan bahwa ketiga produk jamu aman untuk dikonsumsi sesuai aturan pakai. Namun, pengawasan rutin oleh BPOM tetap diperlukan untuk memastikan keamanan produk jamu yang beredar di pasaran. Penelitian lanjutan dengan metode yang lebih sensitif seperti spektrofotometri UV-Vis disarankan untuk memverifikasi hasil ini.
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