Review: Penggunaan Off-Label Obat Golongan Antagonis Reseptor Histamin 2
Bilah Samping Artikel
Isi Artikel Utama
Page: 266-272
Abstrak
Saat ini obat golongan antagonis reseptor histamin 2 (H2) telah banyak digunakan untuk indikasi yang cukup luas termasuk untuk penggunaan sebagai obat off-label. Walaupun berpotensi meningkatkan risiko reaksi obat yang merugikan, pada kondisi tertentu penggunaan obat off-label menjadi satu-satunya pilihan bagi tenaga medis. Review ini bertujuan untuk memberikan gambaran tentang seberapa luas penggunaan off-label obat golongan antagonis reseptor H2 yang meliputi ranitidin, simetidin, famotidin, dan nizatidin. Hasil review ini diharapkan dapat menjadi bahan evaluasi bagi pemerintah, produsen obat, maupun praktisi kesehatan. Metode yang digunakan dalam review ini adalah studi terhadap literatur yang diperoleh melalui beberapa layanan seperti PubMed®, ScienceDirect®, dan Google Scholar. Hasil review ini menunjukkan penggunaan off-label obat golongan antagonis reseptor H2 adalah sebagai upaya kuratif dan preventif untuk mengatasi beberapa penyakit yaitu off-label dalam kategori usia pasien, dosis, dan indikasi.
Unduhan
Rincian Artikel
Artikel ini berlisensiCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Referensi
Alsamarai, A. M., Hasan, A. A., & Alobaidi, A. H. (2012). Evaluation of different combined regimens in the treatment of cholinergic urticaria. World Allergy Organization Journal, 5(8), 88–93. https://doi.org/10.1097/WOX. 0b013e31825a72fc
Alsultany, H. A., & Alshibly, I. K. (2014). Immunimodulating Activity of Cimetidine in Iraqi Children and Adolescents with Common Warts Hussein. Medical Journal of Babylon, 11(3), 547–556.
Barletta, J. F., Lat, I., Micek, S. T., Cohen, H., Olsen, K. M., & Haas, C. E. (2015). Off-label use of gastrointestinal medications in the intensive care unit. Journal of Intensive Care Medicine, 30(4), 217–225. https://doi.org/10. 1177/0885066613516574
Barroso-Sousa, R., Vaz-Luis, I., Di Meglio, A., Hu, J., Li, T., Rees, R., Lin, N. U. (2021). Prospective Study Testing a Simplified Paclitaxel Premedication Regimen in Patients with Early Breast Cancer. Oncologist, 26(11), 927–933. https:// doi.org/10.1002/onco.13960
Batubara, C. A., Ritarwan, K., & Rambe, A. S. (2018). Effectiveness differences of ranitidine and omeprazole in prevention of stress ulcer and its effect on pneumonia occurrence and outcome of acute stroke patients. IOP Conference Series: Earth and Environmental Science, 125(1). https: //doi.org/10.1088/17551315/125/1/012205
Borentain, P., Carmona, S., Mathieu, S., Jouve, E., El-Battari, A., & Gérolami, R. (2016). Inhibition of E-selectin expression on the surface of endothelial cells inhibits hepatocellular carcinoma growth by preventing tumor angiogenesis. Cancer Chemotherapy and Pharmacology, 77(4), 847–856. https://doi.org/10.1007/s0028001 63 006-x
Chantharakhit, C., Ruchakorn, T., Mungkornkaew, S., Amorntrakoon, P., Tassanamethee, S., Theeratrakul, P., & Sujaritvanichpong, N. (2022). Efficacy of Premedication Protocol without Ranitidine for Taxane Regimen: A Multicenter Non-Randomized Historical Controlled Study. Asian Pacific Journal of Cancer Prevention, 23(4), 1331–1336. https://doi.org/10.31557/APJCP.2022.23.4.1331
Cox, J. M., van Doorn, L., Malmberg, R., Oomen-de Hoop, E., Bosch, T. M., van den Bemt, P. M. L. A., … van Leeuwen, R. W. F. (2021). The added value of H2 antagonists in premedication regimens during paclitaxel treatment. British Journal of Cancer, 124(10), 1647–1652. https://doi.org/10.1038-/s41416-021-01313-0
Das, B. B., Anton, K., Soares, N., Riojas, S., Mcdermott, J., Knox, L., … Puente, B. N. (2018). Cimetidine: A Safe Treatment Option for Cutaneous Warts in Pediatric Heart Transplant Recipients. Medical Sciences, 6(2), 30. https://doi.org/10.3390/medsci60-20030
De Giorgi, R., & Series, H. (2016). Treatment of Inappropriate Sexual Behavior in Dementia. Current Treatment Options in Neurology, 18(9). https://doi.org/10.1007/s11940-016-0425-2
Fedorowicz, Z., van Zuuren, E. J., & Hu, N. (2012). Histamine H2-receptor antagonists for urticaria. Cochrane Database of Systematic Reviews, 2012(3). https://doi.-org/10.1002/14651858.CD008596.pub2
Ferreira, L. de A., Ibiapina, C. da C., Machado, M. G. P., & Fagundes, E. D. T. (2012). High prevalence of off-label and unlicensed drug prescribing in a Brazilian intensive care unit. Revista da Associação Médica Brasileira (English Edition), 58(1), 82–87. https://doi.org/10.1016/s22554823(12)70159-5
Gu, X. J., Chen, R., Sun, C. H., Zheng, W., Yang, X. H., Wang, S. Bin, … Xiang, Y. T. (2018). Effect of adjunctive ranitidine for antipsychotic-induced weight gain: A systematic review of randomized placebo-controlled trials. Journal of International Medical Research, 46(1), 22–32. https:// doi.org/10.1177/0300060517716783
Guevara-Gutierrez, E., Bonilla-Lopez, S., Hernández-Arana, S., & Tlacuilo-Parra, A. (2015). Safety and efficacy of cetirizine versus cetirizine plus ranitidine in chronic urticaria: Double-blind randomized placebo-controlled study. Journal of Dermatological Treatment, 26(6), 548–550. https:// doi.org/10.3109/09546634.2015.1025031
Hawwa, A. F., Westwood, P. M., Collier, P. S., Millership, J. S., Yakkundi, S., Thurley, G., Mcelnay, J. C. (2013). Prophylactic ranitidine treatment in critically ill children - a population pharmacokinetic study. British Journal of Clinical Pharmacology, 75(5), 1265–1276. https://doi.org/10.1111/j.1365-2125.2012.04473.x
Hogan, R. B., Hogan, R. B., Cannon, T., Rappai, M., Studdard, J., Paul, D., & Dooley, T. P. (2020). Dual-histamine receptor blockade with cetirizine famotidine reduces pulmonary symptoms in COVID-19 patients. Pulmonary Pharmacology and Therapeutics, 63(June), 101942. https://doi.org/10.1016/j. pupt.2020 01942
Ibrahim, S. S. A., El-Aal, S. A. A., Reda, A. M., Achy, S. El, & Shahine, Y. (2022). Anti-neoplastic action of Cimetidine/Vitamin C on histamine and the PI3K/AKT/mTOR pathway in Ehrlich breast cancer. Scientific Reports, 12(1), 1–21. https://doi.org/10.1038/s41598-022-15551-6
Jung, K., LePendu, P., Chen, W. S., Iyer, S. V., Readhead, B., Dudley, J. T., & Shah, N. H. (2014). Automated detection of off-label drug use. PLoS ONE, 9(2). https://doi.org/ 10.1371/journal.pone.0089324
Kubecova, M., Kolostova, K., Pinterova, D., Kacprzak, G., & Bobek, V. (2011). Cimetidine: An anticancer drug? European Journal of Pharmaceutical Sciences, 42(5), 439–444. https://doi.org/10.1016/j.ejps.2011.02.004
Losurdo, G., Principi, M., Girardi, B., Pricci, M., Barone, M., Ierardi, E., & Di Leo, A. (2016). Histamine and Histaminergic Receptors in Colorectal Cancer: From Basic Science to Evidence-based Medicine. Anti-Cancer Agents in Medicinal Chemistry, 18(1), 15–20. https://doi.org/10.2174/1871520616666 160321115349
Mahdayana, I. D., Sudjatmiko, S., Sumarno, S., & Padolo, E. (2020). Studi Penggunaan Profilaksis Stress Ulcer pada Pasien Bedah Digestif di RSUD dr.Soetomo Surabaya. Pharmaceutical Journal of Indonesia, 005(02), 73–78. https://doi.org/10.21776/ub. pji.2020.005.02.1
Mather, J. F., Seip, R. L., & McKay, R. G. (2020). Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients with COVID-19. American Journal of Gastroenterology, 115(10), 1617–1623. https://doi.org/10.14309/ajg.0000000000000832
Mehta, V. S., & Ram, D. (2016). Efficacy of ranitidine in olanzapine-induced weight gain: a dose–response study. Early Intervention in Psychiatry, 10(6), 522–527. https://doi.org/-10.1111/eip.12205
Morgan, K. A., & Ahlawat, R. (2022). Ranitidine. Diambil 21 November 2022, dari https://-www.ncbi.nlm.nih.gov/books/NBK532989/
National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Nizatidine. Diambil 21 November 2022, dari LiverTox: Clinical and Research Information on Drug-Induced Liver Injury website: https://www.ncbi.nlm-.nih.gov/books/NBK548387/
Nguyen, K., Dersnah, G. D., & Ahlawat, R. (2022). Famotidine. Diambil 21 November 2022, dari https://www.ncbi.nlm.nih.gov/books/NBK534778/
Nugent, C. C., Falkson, S. R., & Terrell, J. M. (2022). H2 Blockers. Diambil 21 November 2022, dari https://www.ncbi.nlm.nih.gov/-books/NBK525994/
Piñeiro Pérez, R., Núñez Cuadros, E., Rodríguez Marrodán, B., Escrig Fernández, R., Gil Lemus, M. Á., Manzano Blanco, S., & Calvo, C. (2021). Off-label pediatric medicines in Spain. Anales de Pediatría (English Edition), 94(3), 188.e1-188.e9. https://doi.org/10.10-16/j.anpede.2020.12.008
Pino, M. A., & Azer, S. A. (2022). Cimetidine. Diambil 21 November 2022, dari https-://www.ncbi.nlm.nih.gov/books/NBK544255/
Pires, J., Junior, A. S., & Dalgalarrondo, P. (2013). 1568. Cimetidine prescription for inappropriate sexual behaviors in child and adolescent psychiatry. European Psychiatry, 28, 1. https://doi.org/10.1016/s0924-9338 (13)76572-6
Rado, J. T., Keim, K. S., & Dowrd, S. M. (2013). Management of Antipsychotic-Induced Weight Gain: Part II. Psychopharm, 48(7), 49–56.
Ryan, M., Snoswell, C., & Carrington, C. (2022). Is the use of ranitidine required as a pre-medication to prevent hypersensitivity reactions to paclitaxel? Journal of Pharmacy Practice and Research, 52(1), 53–58. https://doi.org/10.1002/jppr.1768
Sucasas Alonso, A., Avila-Alvarez, A., Combarro Eiriz, M., Martínez Roca, C., Yáñez Gómez, P., Codias López, A., Pértega Díaz, S. (2019). Use of off-label drugs in neonatal intensive care. Anales de Pediatría (English Edition), 91(4), 237–243. https ://doi.org/10.1016/j.anpede.2018.12.005
Syahrina, N. A. (2014). Identifikasi Penggunaan Obat Off-Label Pada Pasien Dewasa Rawat Inap di Rumah Sakit Pku Muhammadiyah Yogyakarta Periode Januari-Desember Tahun 2014 (Universitas Muhammadiyah Yogyakarta). Universitas Muhammadiyah Yogyakarta, Yogyakarta. Diambil dari http://repository.umy.ac.id/bitstream/handle/123456789/7275/12. Naskah Publikasi-.pdf?sequence=12#
Troxler, R. B., & Harding, S. M. (2014). Chapter 11 - Sleep and Gastroesophageal Reflux. In S. H. Sheldon, R. Ferber, M. H. Kryger, & D. B. T.-P. and P. of P. S. M. (Second E. Gozal (Ed.), Principles and Practice of Pediatric Sleep Medicine (Second Ed, hal. 83–90). Philadelphia: W.B. Saunders. https://doi.org-/https://doi.org/10.1016/B978-1-4557-0318-0.00011-5
Tuloli, T. S., Rasdianah, N., & Datau, M. (2022). Gambaran Penggunaan Obat Off-Label Pada Pasien Pediatrik Rawat Inap Di Rumah Sakit. Indonesian Journal of Pharmaceutical Education, 2(2), 130–142. https://doi.org/10.37311/ijpe.v2i2.11449
Wolverton, S. E. (2013). Comprehensive Dermatologic Drug Therapy (3rd Ed.). Indiana: Elsevier Health Sciences.
Wu, C. Y., & Chang, C. H. (2016). Treating recalcitrant verruca vulgaris in a pediatric patient with H2 blocker: An easy alternative approach. Journal of the Formosan Medical Association, 115(5), 380–381. https://doi.-org/10.1016/j.jfma.2015.06.011
Yang, H., George, S. J., Thompson, D. A., Silverman, H. A., Tsaava, T., Tynan, A., … Tracey, K. J. (2022). Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm. Molecular Medicine, 28(1). https://doi.org/10.1186/s-10020-022-00483-8
Zheng, Z., Yang, M., & Wu, J. (2017). Ethical off-label drug-use: Need for a rethink? Indian Pediatrics, 54(6), 447–450. https://doi.org/ 10.1007/s13312-017-1045-y