Review: Off-Label Drug Uses of Histamine 2 Receptor Antagonist
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Abstract
Histamine 2 (H2) receptor antagonist drugs have been widely used for a wide range of indications, including for use as off-label drugs. Even though it can potentially increase the risk of adverse drug reactions, under certain conditions, using off-label drugs is the only option for medical personnel. This review aims to provide an overview of the widespread off-label use of H2 receptor antagonists, including ranitidine, cimetidine, famotidine, and nizatidine. The results of this review are expected to be used as evaluation material by the government, drug manufacturers, and health practitioners. The method used in this review is a study of literature obtained through several services, such as PubMed®, ScienceDirect®, and Google Scholar. The results of this review show that using off-label H2 receptor antagonist drugs is a curative and preventive effort to overcome several diseases, namely off-label in the categories of patient age, dosage, and indications.
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References
Alsamarai, A. M., Hasan, A. A., & Alobaidi, A. H. (2012). Evaluation of different combined regimens in the treatment of cholinergic urticaria. World Allergy Organization Journal, 5(8), 88–93. https://doi.org/10.1097/WOX. 0b013e31825a72fc
Alsultany, H. A., & Alshibly, I. K. (2014). Immunimodulating Activity of Cimetidine in Iraqi Children and Adolescents with Common Warts Hussein. Medical Journal of Babylon, 11(3), 547–556.
Barletta, J. F., Lat, I., Micek, S. T., Cohen, H., Olsen, K. M., & Haas, C. E. (2015). Off-label use of gastrointestinal medications in the intensive care unit. Journal of Intensive Care Medicine, 30(4), 217–225. https://doi.org/10. 1177/0885066613516574
Barroso-Sousa, R., Vaz-Luis, I., Di Meglio, A., Hu, J., Li, T., Rees, R., Lin, N. U. (2021). Prospective Study Testing a Simplified Paclitaxel Premedication Regimen in Patients with Early Breast Cancer. Oncologist, 26(11), 927–933. https:// doi.org/10.1002/onco.13960
Batubara, C. A., Ritarwan, K., & Rambe, A. S. (2018). Effectiveness differences of ranitidine and omeprazole in prevention of stress ulcer and its effect on pneumonia occurrence and outcome of acute stroke patients. IOP Conference Series: Earth and Environmental Science, 125(1). https: //doi.org/10.1088/17551315/125/1/012205
Borentain, P., Carmona, S., Mathieu, S., Jouve, E., El-Battari, A., & Gérolami, R. (2016). Inhibition of E-selectin expression on the surface of endothelial cells inhibits hepatocellular carcinoma growth by preventing tumor angiogenesis. Cancer Chemotherapy and Pharmacology, 77(4), 847–856. https://doi.org/10.1007/s0028001 63 006-x
Chantharakhit, C., Ruchakorn, T., Mungkornkaew, S., Amorntrakoon, P., Tassanamethee, S., Theeratrakul, P., & Sujaritvanichpong, N. (2022). Efficacy of Premedication Protocol without Ranitidine for Taxane Regimen: A Multicenter Non-Randomized Historical Controlled Study. Asian Pacific Journal of Cancer Prevention, 23(4), 1331–1336. https://doi.org/10.31557/APJCP.2022.23.4.1331
Cox, J. M., van Doorn, L., Malmberg, R., Oomen-de Hoop, E., Bosch, T. M., van den Bemt, P. M. L. A., … van Leeuwen, R. W. F. (2021). The added value of H2 antagonists in premedication regimens during paclitaxel treatment. British Journal of Cancer, 124(10), 1647–1652. https://doi.org/10.1038-/s41416-021-01313-0
Das, B. B., Anton, K., Soares, N., Riojas, S., Mcdermott, J., Knox, L., … Puente, B. N. (2018). Cimetidine: A Safe Treatment Option for Cutaneous Warts in Pediatric Heart Transplant Recipients. Medical Sciences, 6(2), 30. https://doi.org/10.3390/medsci60-20030
De Giorgi, R., & Series, H. (2016). Treatment of Inappropriate Sexual Behavior in Dementia. Current Treatment Options in Neurology, 18(9). https://doi.org/10.1007/s11940-016-0425-2
Fedorowicz, Z., van Zuuren, E. J., & Hu, N. (2012). Histamine H2-receptor antagonists for urticaria. Cochrane Database of Systematic Reviews, 2012(3). https://doi.-org/10.1002/14651858.CD008596.pub2
Ferreira, L. de A., Ibiapina, C. da C., Machado, M. G. P., & Fagundes, E. D. T. (2012). High prevalence of off-label and unlicensed drug prescribing in a Brazilian intensive care unit. Revista da Associação Médica Brasileira (English Edition), 58(1), 82–87. https://doi.org/10.1016/s22554823(12)70159-5
Gu, X. J., Chen, R., Sun, C. H., Zheng, W., Yang, X. H., Wang, S. Bin, … Xiang, Y. T. (2018). Effect of adjunctive ranitidine for antipsychotic-induced weight gain: A systematic review of randomized placebo-controlled trials. Journal of International Medical Research, 46(1), 22–32. https:// doi.org/10.1177/0300060517716783
Guevara-Gutierrez, E., Bonilla-Lopez, S., Hernández-Arana, S., & Tlacuilo-Parra, A. (2015). Safety and efficacy of cetirizine versus cetirizine plus ranitidine in chronic urticaria: Double-blind randomized placebo-controlled study. Journal of Dermatological Treatment, 26(6), 548–550. https:// doi.org/10.3109/09546634.2015.1025031
Hawwa, A. F., Westwood, P. M., Collier, P. S., Millership, J. S., Yakkundi, S., Thurley, G., Mcelnay, J. C. (2013). Prophylactic ranitidine treatment in critically ill children - a population pharmacokinetic study. British Journal of Clinical Pharmacology, 75(5), 1265–1276. https://doi.org/10.1111/j.1365-2125.2012.04473.x
Hogan, R. B., Hogan, R. B., Cannon, T., Rappai, M., Studdard, J., Paul, D., & Dooley, T. P. (2020). Dual-histamine receptor blockade with cetirizine famotidine reduces pulmonary symptoms in COVID-19 patients. Pulmonary Pharmacology and Therapeutics, 63(June), 101942. https://doi.org/10.1016/j. pupt.2020 01942
Ibrahim, S. S. A., El-Aal, S. A. A., Reda, A. M., Achy, S. El, & Shahine, Y. (2022). Anti-neoplastic action of Cimetidine/Vitamin C on histamine and the PI3K/AKT/mTOR pathway in Ehrlich breast cancer. Scientific Reports, 12(1), 1–21. https://doi.org/10.1038/s41598-022-15551-6
Jung, K., LePendu, P., Chen, W. S., Iyer, S. V., Readhead, B., Dudley, J. T., & Shah, N. H. (2014). Automated detection of off-label drug use. PLoS ONE, 9(2). https://doi.org/ 10.1371/journal.pone.0089324
Kubecova, M., Kolostova, K., Pinterova, D., Kacprzak, G., & Bobek, V. (2011). Cimetidine: An anticancer drug? European Journal of Pharmaceutical Sciences, 42(5), 439–444. https://doi.org/10.1016/j.ejps.2011.02.004
Losurdo, G., Principi, M., Girardi, B., Pricci, M., Barone, M., Ierardi, E., & Di Leo, A. (2016). Histamine and Histaminergic Receptors in Colorectal Cancer: From Basic Science to Evidence-based Medicine. Anti-Cancer Agents in Medicinal Chemistry, 18(1), 15–20. https://doi.org/10.2174/1871520616666 160321115349
Mahdayana, I. D., Sudjatmiko, S., Sumarno, S., & Padolo, E. (2020). Studi Penggunaan Profilaksis Stress Ulcer pada Pasien Bedah Digestif di RSUD dr.Soetomo Surabaya. Pharmaceutical Journal of Indonesia, 005(02), 73–78. https://doi.org/10.21776/ub. pji.2020.005.02.1
Mather, J. F., Seip, R. L., & McKay, R. G. (2020). Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients with COVID-19. American Journal of Gastroenterology, 115(10), 1617–1623. https://doi.org/10.14309/ajg.0000000000000832
Mehta, V. S., & Ram, D. (2016). Efficacy of ranitidine in olanzapine-induced weight gain: a dose–response study. Early Intervention in Psychiatry, 10(6), 522–527. https://doi.org/-10.1111/eip.12205
Morgan, K. A., & Ahlawat, R. (2022). Ranitidine. Diambil 21 November 2022, dari https://-www.ncbi.nlm.nih.gov/books/NBK532989/
National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Nizatidine. Diambil 21 November 2022, dari LiverTox: Clinical and Research Information on Drug-Induced Liver Injury website: https://www.ncbi.nlm-.nih.gov/books/NBK548387/
Nguyen, K., Dersnah, G. D., & Ahlawat, R. (2022). Famotidine. Diambil 21 November 2022, dari https://www.ncbi.nlm.nih.gov/books/NBK534778/
Nugent, C. C., Falkson, S. R., & Terrell, J. M. (2022). H2 Blockers. Diambil 21 November 2022, dari https://www.ncbi.nlm.nih.gov/-books/NBK525994/
Piñeiro Pérez, R., Núñez Cuadros, E., Rodríguez Marrodán, B., Escrig Fernández, R., Gil Lemus, M. Á., Manzano Blanco, S., & Calvo, C. (2021). Off-label pediatric medicines in Spain. Anales de Pediatría (English Edition), 94(3), 188.e1-188.e9. https://doi.org/10.10-16/j.anpede.2020.12.008
Pino, M. A., & Azer, S. A. (2022). Cimetidine. Diambil 21 November 2022, dari https-://www.ncbi.nlm.nih.gov/books/NBK544255/
Pires, J., Junior, A. S., & Dalgalarrondo, P. (2013). 1568. Cimetidine prescription for inappropriate sexual behaviors in child and adolescent psychiatry. European Psychiatry, 28, 1. https://doi.org/10.1016/s0924-9338 (13)76572-6
Rado, J. T., Keim, K. S., & Dowrd, S. M. (2013). Management of Antipsychotic-Induced Weight Gain: Part II. Psychopharm, 48(7), 49–56.
Ryan, M., Snoswell, C., & Carrington, C. (2022). Is the use of ranitidine required as a pre-medication to prevent hypersensitivity reactions to paclitaxel? Journal of Pharmacy Practice and Research, 52(1), 53–58. https://doi.org/10.1002/jppr.1768
Sucasas Alonso, A., Avila-Alvarez, A., Combarro Eiriz, M., Martínez Roca, C., Yáñez Gómez, P., Codias López, A., Pértega Díaz, S. (2019). Use of off-label drugs in neonatal intensive care. Anales de Pediatría (English Edition), 91(4), 237–243. https ://doi.org/10.1016/j.anpede.2018.12.005
Syahrina, N. A. (2014). Identifikasi Penggunaan Obat Off-Label Pada Pasien Dewasa Rawat Inap di Rumah Sakit Pku Muhammadiyah Yogyakarta Periode Januari-Desember Tahun 2014 (Universitas Muhammadiyah Yogyakarta). Universitas Muhammadiyah Yogyakarta, Yogyakarta. Diambil dari http://repository.umy.ac.id/bitstream/handle/123456789/7275/12. Naskah Publikasi-.pdf?sequence=12#
Troxler, R. B., & Harding, S. M. (2014). Chapter 11 - Sleep and Gastroesophageal Reflux. In S. H. Sheldon, R. Ferber, M. H. Kryger, & D. B. T.-P. and P. of P. S. M. (Second E. Gozal (Ed.), Principles and Practice of Pediatric Sleep Medicine (Second Ed, hal. 83–90). Philadelphia: W.B. Saunders. https://doi.org-/https://doi.org/10.1016/B978-1-4557-0318-0.00011-5
Tuloli, T. S., Rasdianah, N., & Datau, M. (2022). Gambaran Penggunaan Obat Off-Label Pada Pasien Pediatrik Rawat Inap Di Rumah Sakit. Indonesian Journal of Pharmaceutical Education, 2(2), 130–142. https://doi.org/10.37311/ijpe.v2i2.11449
Wolverton, S. E. (2013). Comprehensive Dermatologic Drug Therapy (3rd Ed.). Indiana: Elsevier Health Sciences.
Wu, C. Y., & Chang, C. H. (2016). Treating recalcitrant verruca vulgaris in a pediatric patient with H2 blocker: An easy alternative approach. Journal of the Formosan Medical Association, 115(5), 380–381. https://doi.-org/10.1016/j.jfma.2015.06.011
Yang, H., George, S. J., Thompson, D. A., Silverman, H. A., Tsaava, T., Tynan, A., … Tracey, K. J. (2022). Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm. Molecular Medicine, 28(1). https://doi.org/10.1186/s-10020-022-00483-8
Zheng, Z., Yang, M., & Wu, J. (2017). Ethical off-label drug-use: Need for a rethink? Indian Pediatrics, 54(6), 447–450. https://doi.org/ 10.1007/s13312-017-1045-y