Studi in silico senyawa Echinochrome-A, Spinochrome-A, and Echinamine-A pada Echinometra mathaei dalam menghambat enzim maltase-glucoamylase sebagai antidiabetes
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DM dapat disebabkan oleh adanya pelepasan dan penyerapan glukosa di usus kecil oleh enzim pencernaan. Penghambatan enzim tersebut dapat membantu pengelolaan DM. Human Maltase-glucoamylase (MGA) merupakan salah satu enzim pada usus kecil yang bertanggungjawab untuk mengkatalisis pelepasan glukosa dari pencernaan karbohidrat. Dengan menghambat enzim ini diharapkan glukosa pada pasien diabetes tipe 2 dapat terkontrol. Menganalisis potensi Echinochrome-A, Spinochrome-A, dan Echinamine-A pada ekstrak Echinometra mathaei sebagai antidiabetes dengan menggunakan molekular doking. Molekular doking menggunakan Echinochrome-A, Spinochrome-A, dan Echinamine-A sebagai senyawa uji dan Miglitol sebagai pembanding terhadap reseptor Human Maltase-glucoamylase (3CTT). Echinochrome-A, Spinochrome-A, Echinamine-A memiliki afinitas dan ikatan hidrogen dengan residu asam amino yang tidak berbeda signifikan dengan Miglitol, sehingga Echinochrome-A, Spinochrome-A, dan Echinamine-A berpotensi sebagai antidiabetes.
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