Review: Analisis Senyawa Obat Warfarin dalam Plasma Darah dengan Metode HPLC/KCKT
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Warfarin merupakan turunan sintetik kumarin yang penggunaannya sebagai antikoagulan oral yang biasa digunakan untuk mencegah dan mengobati penggumpalan darah, profilaksis dan pengobatan emboli paru dan trombosis vena, profilaksis dan pengobatan komplikasi tromboemboli dari fibrilasi atrium atau penggantian katup jantung, serta risiko kematian dari infark miokard berulang, dan kejadian tromboemboli setelah infark miokard dapat di kurangi. Warfarin merupakan indeks terapi sempit antikoagulan oral yang apabila adanya perubahan sedikit kadar obat warfarin pada darah maka dapat terdadi perubahan respons efek. telah banyak dikembangkan berbagai teknik analitik bagi analisis kadar warfarin yang ada dalam plasma darah, contohnya seperti menggunakan High-Performance Liquid Chromatography ditambah dengan deteksi ultraviolet/fluoresensi, SFC-MS/MS, LC-MS/MS, CZE dengan deteksi ultraviolet, dan MEKC-ESI–MS. Metode uji yang digunakan untuk pemantauan Artikel Review ini memiliki tujuan sebagai tinjauan dan perbandingan metode analisis/teknik pendeteksian yang digunakan pada analisis warfarin yang ada dalam plasma darah. Metode HPLC memiliki beberapa keuntungan dalam analisis kadar obat warfarin, yaitu seperti kemudahan, keakuratan, efektifitas waktu analisa, serta keunggulan sensitivitas dan selektivitas yang tinggi.
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