Qualitative Analysis of Paracetamol Compounds in Biological Samples Using Gas Chromatography - Mass Spectrometry (GC-MS) Method
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Abstract
In this review article, an analysis was carried out regarding the use of the Gas Chromatography - Mass Spectrometry (GC-MS) method in the qualitative analysis of paracetamol compounds in various biological samples such as blood, serum, hair, and urine. Paracetamol is a non-opioid analgesic drug used to relieve mild to moderate pain. The method used in writing this article is a literature study using primary data in the form of national journals from the Google Scholar and Sinta databases. The search was carried out using keywords related to the qualitative analysis of paracetamol compounds using the GC-MS method on biological samples. The purpose of reviewing this article is to compare the treatment and preparation processes of various biological samples used in the qualitative analysis of paracetamol compounds using the Gas Chromatography - Mass Spectrometry (GC-MS) method, such as blood, serum, hair, and urine. The results of the study of several journals showed that there were several biological samples used in the qualitative analysis of paracetamol using the GC-MS method, namely blood, serum, hair and urine. Each biological sample has different preparation and extraction procedures according to the characteristics of the matrix. It can be concluded that of the four samples, hair samples can show positive results in a longer period of time while blood and urine samples can only provide drug information for a few days.
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References
Aisyah, N., & Rosnita, R. (2021). Pengaruh Project Based Learning pada Materi Sistem Koordinasi terhadap Hasil Belajar Kognitif Siswa. Jurnal Biolokus: Jurnal Penelitian Pendidikan Biologi dan Biologi, 4(1), 14-19. http://dx.doi.org/10.30821/biolokus.v4i1.816
Aprida, C. D., Prayuda, E. M., Odhia, F. N., Andriani, N., Tyasna, P. S., Nailuvar, R., & Andini, S. D. (2022). Analisis Senyawa Acetaminophen pada Spesimen Rambut Manusia Menggunakan Metode Kromatografi Gas-Spektrometri Massa (GC-MS). Syntax Idea, 4(5), 861-870.
Candraningrat, I. D. A. A., Santika, A. A. G. J., Dharmayanti, I. A. M. S., & Prayascita, P. W. (2021). Review Kemampuan Metode GS-MS dalam Identifikasi Flunitrazepam Terkait dengan Aspek Forensik dan Klinik. Jurnal Kimia, 15(1), 12. DOI:https://doi.org/10.24843/jchem.2021.v15.i01.p03
Darmapatni, K. A. G., Putra, A. A., Ariati, N. K., & Suaniti, N. M. (2014). Analisis Kualitatif Senyawa Parasetamol (Acetaminophen) pada Urin dan Rambut Menggunakan Kromatografi Gas-Spektrometri Massa (Gc-Ms). Jurnal Kimia, 8(2), 257–262.
Darmapatni, K. A. G., Basori, A., & Suaniti, N. M. (2016). Pengembangan Metode GC-MS untuk Penetapan Kadar Acetaminophen pada Spesimen Rambut Manusia. Jurnal Biosains Pascasarjana, 18(3), 255-266.
Fransiska, N. A., Masyrofah, D., Putri, G. K., Malik, L. H., Wulanbirru, P., & Putri, T. R. (2022). Analisis Senyawa Obat dalam Sampel Biologis Plasma Darah. Syntax Idea, 4(5), 905-912.
Hotmian, E., Suoth, E., Fatimawali, F., & Tallei, T. (2021). Analisis Gc-Ms (Gas Chromatography - Mass Spectrometry) Ekstrak Metanol Dari Umbi Rumput Teki (Cyperus rotundus L.). Pharmacon, 10(2), 849. DOI: https://doi.org/10.35799/pha.10.2021.34034
Marlina, D. (2013). Pengaruh Pemberian Ekstrak Tempe terhadap Kadar Ureum dan Kreatinin Ginjal Tikus Putih Jantan Galur WIstar (Rattus norvegicus) dengan Pemberian Parasetamol Dosis Toksik. Jurnal Kesehatan, 1(11), 115-123.
Muldianah, D., Sulastri, Fatharani, A., Nurdimayanthi, D. A., Rahmawati, D. S., & Fadhilah, H. (2022). Metode Analisis Paracetamol (Acetaminophen) dalam Darah, Plasma, dan Serum Manusia. Jurnal Penelitian dan Pengabdian Masyarakat, 2(1), 1-12. DOI: https://doi.org/10.59141/comserva.v2i1.202
Rahmatia, T. U. (2016). Metode SPE (Solid Phase Extraction) sebagai Alternatif Terbaru dalam Analisis dan Pemurnian Senyawa Obat. Farmaka, 14(2), 151-171. DOI: https://doi.org/10.24198/jf.v14i2.10822
Sebayang, R., Idawati, Y., & Sinaga, H. (2020). Analisis Lactat Dehydrogenase dalam Serum Darah Menggunakan Sentrifugasi. Jurnal Keperawatan Silampari, 4(1), 274-280. DOI: https://doi.org/10.31539/jks.v4i1.1450
Sudarma, N., & Subhaktiyasa, I. P. G. (2021). Analisis Kadar Paracetamol pada Darah dan Serum. Bali Medika Jurnal, 8(3), 285–293. DOI: https://doi.org/10.36376/bmj.v8i3.177
Taylor, R. R., Hoffman, K. L., Schniedewind, B., Clavijo, C., Galinkin, J. L., & Christians, U. (2013). Comparison of The Quantification of Acetaminophen in Plasma, Cerebrospinal Fluid and Dried Blood Spots Using High-performance Liquid Chromatography–tandem Mass Spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 83, 1–9. DOI : https://doi.org/10.1016/j.jpba.2013.04.007