Utilization of the ICF Framework and DASH-Based Disability Mapping to Assess the Impact of Diagnostic Delay on Functional Disability among Leprosy Patients at dr. Moewardi General Hospital, Surakarta
Main Article Content
Page: 2772-2785
Abstract
Background: Leprosy remains a significant public health problem in Indonesia. Leprosy-related nerve damage produces impairment of body function and structure, activity limitation and participation restriction as conceptualised in the International Classification of Functioning, Disability and Health (ICF). Objective: To analyse the association between diagnostic and treatment delay and functional disability, interpreted within the ICF-WHO 2021 disability components. Methods: This was an analytic observational study with a cross-sectional design involving 20 leprosy patients recruited between November 2025 and January 2026. Functional disability was measured with the validated Indonesian version of the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire, whose items were linked to ICF body function, activity and participation codes. Associations were analysed using the Spearman rank correlation test, with the 95% confidence interval (CI). Results: Most patients were male (95%), with a mean age of 44.2 ± 13.7 years and a mean DASH score of 49.9 ± 21.1. Spearman analysis demonstrated a very strong positive correlation between delay and functional disability (rk = 0.802; 95% CI 0.547–0.921; p < 0.001). Mean DASH score increased progressively from 22.1 in patients treated within 6 months to 96.3 in those treated after more than 24 months. Conclusion: Delayed diagnosis and initiation of MDT are strongly associated with greater functional disability in leprosy patients. Because the analysis was bivariate in a single-centre sample of 20 multibacillary patients, and because DASH covers only part of the ICF framework and does not measure quality of life directly, these findings should be regarded as preliminary.
Downloads
Article Details

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
References
Froes Junior LAR, Sotto MN, Trindade MAB. Leprosy in the 21st century: a comprehensive review of immunological mechanisms, diagnosis, and treatment. Rev Inst Med Trop Sao Paulo. 2025;67:74-75.
World Health Organization. Global leprosy (Hansen disease) update, 2019: Time to step-up prevention initiatives. Wkly Epidemiol Rec. 2020;95:417-40.
Rathod SP, Jagati A, Chowdhary P. Disabilities in leprosy: An open, retrospective analyses of institutional records. An Bras Dermatol. 2020;95:52-6.
Global leprosy (Hansen disease) update, 2023: Elimination of leprosy disease is possible - Time to act. World Health Organization; 2024;80:1-2.
World Health Organization. Leprosy (Hansen disease). 2024;2-3.
Sebong PH, Ferdiana A, Tegu FAR, Harbianto D, Soviandhi R, Sinaga A, et al. Participatory development of Indonesia's national action plan for zero leprosy: Strategies and interventions. Front Public Health. 2025;2:13-14.
Samosir PM, Axelia PG, Alkaff FF, Salamah S, Alinda MD. Prevalence and risk factors for disability in leprosy patients in Indonesia during the post-elimination era. Dermatol Reports. 2023;15-16.
Chen KH, Lin CY, Su SB, Chen KT. Leprosy: A review of epidemiology, clinical diagnosis, and management. J Trop Med. 2022;2022:8-10.
Rashidi M, Pitton Rissardo J, Byroju VV, Fornari Caprara AL, Rashidi F, Prathiraja O, et al. Exploring the neurological manifestations of leprosy: Clinical insights and implications. Cureus. 2025;17-18.
Serrano-Coll H, Restrepo-Rivera L, Cuadros-Urrego Y, Cardona-Castro N. Decoding leprosy: Immune response, clinical manifestations and emerging diagnostic approaches. Trans R Soc Trop Med Hyg. 2025;119:988-98.
Mulugeta SS, Maseresha BM, Wassihun SG, Moyehodie YA. Risk factors for disability upgrading among leprosy patients during treatment: Multilevel modeling analysis. SAGE Open Nurs. 2022;20:8-10.
Wahyuni LK, Nelfidayani N, Harini M, Anestherita F, Wardhani RK, Menaldi SL, et al. The International Classification of Functioning, Disability and Health to map leprosy-related disability in rural and remote areas in Indonesia. PLoS Negl Trop Dis. 2024;18:1-2.
Towards zero leprosy. Global leprosy (Hansen's Disease) strategy 2021-2030. World Health Organization; 2021;10:5-7.
Urgesa K, de Bruijne ND, Bobosha K, Seyoum B, Mihret A, Geda B, et al. Prolonged delays in leprosy case detection in a leprosy hot spot setting in Eastern Ethiopia. PLoS Negl Trop Dis. 2022;16:1-3.
Leon KE, Jacob JT, Franco-Paredes C, Kozarsky PE, Wu HM, Fairley JK. Delayed diagnosis, leprosy reactions, and nerve injury among individuals with Hansen's disease seen at a United States clinic. Open Forum Infect Dis. 2016;3:2-3.
Geetha K. Zero leprosy strategic plans: Global and national level: A short communication. Clin Derm Rev. 2024;8:167-70.
Singh S, Narang T, Dogra S. Beating leprosy: Unmasking challenges, ending stigma, & prioritizing mental well-being. Indian J Med Res. 2025;161:1-4.
Muhaba ES, Geneti SA, Melka D, Mohammed Abdu S. Prevalence, patterns and determinants of peripheral neuropathy among leprosy patients in Northeast Ethiopia: A retrospective study. PLoS Negl Trop Dis. 2025;19:12-24.
Mahendra MA, Hendrati LY. Analysing the problem of finding new cases of grade 2 disabled leprosy. Indonesian Journal of Global Health Research. 2024;6:151-8.
Prameswari A. Gambaran epidemiologi penyakit kusta di Provinsi Jawa Timur tahun 2022. MPPKI (Media Publikasi Promosi Kesehatan Indonesia). 2024;7:1495-9.
Pradhan S, Shahid R, Singh S. Clinicoepidemiologic profile of leprosy in geriatric population in post-elimination era: A retrospective, hospital-based, cross-sectional study from Eastern India. J Family Med Prim Care. 2023;12:2780-5.
Ebenezer GJ, Pena MT, Daniel AS, Truman RW, Adams L, Duthie MS, et al. Mycobacterium leprae induces Schwann cell proliferation and migration in a denervated milieu following intracutaneous excision axotomy in nine-banded armadillos. Exp Neurol. 2022;352:11-15.
Sugawara-Mikami M, Tanigawa K, Kawashima A, Kiriya M, Nakamura Y, Fujiwara Y, et al. Pathogenicity and virulence of Mycobacterium leprae. Virulence. 2022;13:1985-2011.
Serrano-Coll H, Salazar-Pelaez L, Acevedo-Saenz L, Cardona-Castro N. Mycobacterium leprae-induced nerve damage: Direct and indirect mechanisms. Pathog Dis. 2018;76:1-2.
de Souza BJ, Mendes MA, Sperandio da Silva GM, Sammarco-Rosa P, de Moraes MO, Jardim MR, et al. Gene expression profile of Mycobacterium leprae contribution in the pathology of leprosy neuropathy. Front Med (Lausanne). 2022;9:86-88.
Masresha BM, Biresaw HB, Moyehodie YA, Mulugeta SS. Time-to-disability determinants among leprosy patients enrolled for treatment at ALERT center, Addis Ababa, Ethiopia: A survival analysis. Infect Drug Resist. 2022;15:2729-41.
Dos Santos AR, Silva PR de S, Steinmann P, Ignotti E. Disability progression among leprosy patients released from treatment: a survival analysis. Infect Dis Poverty. 2020;9:53-55.
Kaukuntla KP, Jagadevapuram K, Ahmed MN, Ananthula VK. A study of WHO disabilities in leprosy patients before and after multi-drug therapy (MDT). J Contemp Clin Pr. 2025;11:610-7.
Mungroo MR, Khan NA, Siddiqui R. Mycobacterium leprae: Pathogenesis, diagnosis, and treatment options. Microb Pathog. 2020;149:10-14.
Batista KT, Monteiro GB, y-Schwartzman UP, Roberti AFS de SA, Rosa AG, Correia CZ, et al. Treatment of leprosy-induced plantar ulcers. Rev Bras Cir Plast. 2019;34:2-5.
Hashfi AF, Wijayanti W, Mulianto N. Diagnosis and treatment of multibacillary leprosy borderline lepromatous type: A case report. BioSci Med J Biomed Transl Res. 2022;6:2559-65.
Alrehaili J. Leprosy classification, clinical features, epidemiology, and host immunological responses: Failure of eradication in 2023. Cureus. 2023;15:44-6.
Ramesh, Sampath, Shvedha. A clinicopathological correlation in leprosy in a tertiary care teaching institution. Int J Res Dermatol. 2019;5:870-2.
Kumar A, Girdhar A, Girdhar BK. Risk of developing disability in pre and post-multidrug therapy treatment among multibacillary leprosy: Agra MB Cohort study. BMJ Open. 2012;2:20-22.
Kementerian Kesehatan Republik Indonesia. Pedoman Nasional Pelayanan Kedokteran Tata Laksana Kusta. Jakarta: Kementerian Kesehatan Republik Indonesia; 2020;2:2-5.
Mowla MR, Angkur DM, Hasan Z, Sultana MN, Afrin S, Akhter MS. Leprosy patients with deformities at post-elimination stage: The Bangladesh experience. Skin Health Dis. 2021;1:1-5.
Carlin L, McPherson G, Davison R. The International Classification of Functioning Disability and Health Framework (ICF): A new approach to enhance sport and physical activity participation among people with disabilities in Scotland. Front Sports Act Living. 2024;6:121-15.
Sy Savane IS, Sidibe S, Kolie D, Camara M, Sakho F, Sidibe S, et al. Frequency and factors associated with disabilities among leprosy patients admitted to the Kindia Disability Prevention and Physical Rehabilitation Centre (PIRP) in Guinea from 2017 to 2021. Trop Med Infect Dis. 2024;9:237-8.
de Klerk S. Assessment of structural and cross-cultural validity of the Disabilities of the Arm, Shoulder and Hand questionnaire: A scoping review. Hand Ther. 2023;28:3-15.
Lee HJ, Song JM. Linking of items in two function-related questionnaires to the international classification of functioning, disability and health: Shoulder pain. J Korean Phys Ther. 2018;30:239-45.
Geani S, Rahmadewi, Astindari, Prakoeswa CRS, Sawitri, Ervianti E, et al. Risk factors for disability in leprosy patients: a cross-sectional study. Bali Med J. 2022;11:197-201.
Gunawan H, Ruchiatan K, Avriyanti E, Hidayah RMN, Pratama DG. Treatment neglect in multibacillary leprosy leading to osteomyelitis and transtibial amputation: Lessons from endemic setting. Int J Infect Dis. 2026;164:108-10.
Arango-Usuga C, Ochoa J, Hincapie-Palacio D, Leon A. Endemicity, disability and neglect: Leprosy in Colombia 2007-2020. PLoS Negl Trop Dis. 2025;19:20-2.
Srinivas G, Muthuvel T, Lal V, Vaikundanathan K, Schwienhorst-Stich EM, Kasang C. Risk of disability among adult leprosy cases and determinants of delay in diagnosis in five states of India: A case-control study. PLoS Negl Trop Dis. 2019;13:1-2.
Huang CY, Su SB, Chen KT. An update of the diagnosis, treatment, and prevention of leprosy: A narrative review. Medicine (Baltimore). 2024;103:10-5.
Guidelines for the diagnosis, treatment and prevention of leprosy. World Health Organization; 2018;10:1-5.