Interpolated Melolabial Flap as an Aesthetic and Functional Reconstruction Option for Nasal Defects Due to Basal Cell Carcinoma: A Serial Case Report
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Abstract
Basal cell carcinoma (BCC) is a malignant skin neoplasm primarily induced by prolonged ultraviolet (UV) radiation exposure. Various flap techniques, including rotation, transposition and advancement flaps are commonly employed for reconstruction. This report presents two cases of nasal BCC managed using an interpolated melolabial flap as a reconstructive option. The first case involved a 48 years old woman presenting with a progressively enlarging nodule on the left nasal area for one year. The second case was a 58 years old woman with a similar lesion on the right nasal side. Both patients were diagnosed with BCC based on clinical history, dermoscopic evaluation and histopathological confirmation. Wide local excision with adequate surgical margins was performed in both cases, followed by nasal ala reconstruction using an interpolated melolabial flap. Postoperative outcomes were favorable with minimal complications and no evidence of recurrence during follow up. The primary goal of BCC treatment is complete tumor excision with minimal recurrence while also preserving both function and aesthetic integrity. The choice of flap technique is guided by factors such as defect size, anatomical location, tissue characteristics and patient condition. The interpolated flap technique involves transferring tissue while maintaining a skin bridge (pedicle) to ensure sufficient vascular supply and making it a reliable option for complex nasal reconstructions. The interpolated melolabial flap offers excellent aesthetic and functional outcomes with rapid healing and minimal complications, making it a valuable reconstructive approach in the management of nasal basal cell carcinoma.
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References
Peris K, Fargnoli MC, Kaufmann R, Arenberger P, Bastholt L, Seguin NB, et al. European consensus-based interdisciplinary guideline for diagnosis and treatment of basal cell carcinoma-update 2023. Eur J Cancer. 2023;192:32-54. DOI: https://doi.org/10.1016/j.ejca.2023.113254
McDaniel B, Badri T, Steele RB. Basal Cell Carcinoma. StatPearls Publishing; 2024.
Dika E, Scarfì F, Ferracin M, Broseghini E, Marcelli E, Bortolani B, et al. Basal cell carcinoma: A comprehensive review. Int J Mol Sci. 2020;21:1-11. DOI: https://doi.org/10.3390/ijms21155572
Santini CF, Istiadi H, Kusumaningrum N, Miranti IP. Karakteristik Klinikopatologik Karsinoma Sel Basal di RSUP Dr. Kariadi Semarang Periode 1 Januari 2019–31 Desember 2021. Universitas Diponegoro; 2022:22-50.
Kevinsyah AP, Didik SH, Kus E. Profil Histopatologi Karsinoma Sel Basal di Instalasi Patologi Anatomik RSUP Dr. Sardjito Yogyakarta Tahun 2012–2013. Universitas Gadjah Mada.
Bauer A, Haufe E, Heinrich L, Seidler A, Schmitt J. Basal cell carcinoma and solar UV exposition (update on occupational skin cancer-basal cell carcinoma and solar UV exposure). Hautarzt. 2021;72(6):484-492. DOI: https://doi.org/10.1007/s00105-021-04818-0
Toha SS, Rahman A, Mochtar M, Julianto I, Dharmawan N, Mawardi P, et al. Kejadian karsinoma sel basal di RSUD Dr. Moewardi Surakarta berdasarkan subtipe histopatologi menurut jenis kelamin, usia, lokasi anatomi, dan diameter tumor. CDK. 2019;46(4):1-5.
Marei HE, Althani A, Afifi N, Hasan A, Caceci T, Pozzoli G, et al. p53 signaling in cancer progression and therapy. Cancer Cell Int. 2021;21(703):1-15. DOI: https://doi.org/10.1186/s12935-021-02396-8
Cameron MC, Lee E, Hibler BP, Giordano CN, Barker CA, Mori S, et al. Basal cell carcinoma: Contemporary approaches to diagnosis, treatment, and prevention. J Am Acad Dermatol. 2019;80:321-339. DOI: https://doi.org/10.1016/j.jaad.2018.02.083
Cocuz IG, Popelea MC, Niculescu R, Manea A, Sabău AH, Tinca AC, et al. Pathophysiology, histopathology, and differential diagnostics of basal cell carcinoma and cutaneous squamous cell carcinoma—An update from the pathologist’s point of view. Int J Mol Sci. 2024;25(4). DOI: https://doi.org/10.3390/ijms25042220
Richmond-Sinclair NM, Pandeya N, Ware RS, Neale RE, Williams GM, Van Der Pols JC, et al. Incidence of basal cell carcinoma multiplicity and detailed anatomic distribution: Longitudinal study of an Australian population. J Invest Dermatol. 2009;129(2):323-328. DOI: https://doi.org/10.1038/jid.2008.234
Fania L, Didona D, Morese R, Campana I, Coco V, Di Pietro FR, et al. Basal cell carcinoma: From pathophysiology to novel therapeutic approaches. Biomedicines. 2020;8:1-38. DOI: https://doi.org/10.3390/biomedicines8110449
Naik PP, Desai MB. Basal cell carcinoma: A narrative review on contemporary diagnosis and management. Oncol Ther. 2022;10(2):317-335. DOI: https://doi.org/10.1007/s40487-022-00201-8
Nasr I, McGrath EJ, Harwood CA, Botting J, Buckley P, Budny PG, et al. British Association of Dermatologists guidelines for the management of adults with basal cell carcinoma 2021. Br J Dermatol. 2021;185:899-920. DOI: https://doi.org/10.1111/bjd.20524
Ramsey ML, Ellison CA, Hohman MH, Al Aboud AM. Interpolated flaps. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025.
Huentequeo CM, Siso SC, Unibazo AZ, Pino DD, Alister JPH, Mayer, et al. Local flaps in facial reconstruction: Treatment alternatives. Int J Odontostomat. 2021;15(2):538-550. DOI: https://doi.org/10.4067/S0718-381X2021000200538
Salzano G, Maffìa F, Vaira LA, Committeri U, Copelli C, Maglitto F, et al. Locoregional flaps for the reconstruction of midface skin defects: A collection of key surgical techniques. J Clin Med. 2023;12(11):3700. DOI: https://doi.org/10.3390/jcm12113700
Zhang W, Zeng W, Jiang A, He Z, Shen X, Dong X, Feng J, Lu H. Global, regional and national incidence, mortality and disability-adjusted life-years of skin cancers and trend analysis from 1990 to 2019: An analysis of the Global Burden of Disease Study 2019. Cancer Med. 2021;10(14):4905-4922.
Pan Y, Tang B, Guo Y, Cai Y, Li YY. Global burden of non-melanoma skin cancers among older adults: A comprehensive analysis using machine learning approaches. Sci Rep. 2025;15(1):152-166. DOI: https://doi.org/10.1038/s41598-025-99605-5
Kavoussi H, Ebrahimi A, Rezaei M, Najafi F, Zarpoosh M, Kavoussi R. Comparison of demographic and clinicopathological characteristics of basal cell carcinoma on the nose and other sites of the face: A cross-sectional study. Iran J Otorhinolaryngol. 2021;33(118):257-262.
Yang H, Almadani N, Thompson EF, Tessier-Cloutier B, Chen J, Ho J, et al. Classification of vulvar squamous cell carcinoma and precursor lesions by p16 and p53 immunohistochemistry: Considerations, caveats, and an algorithmic approach. Mod Pathol. 2023;36(6):100-145. DOI: https://doi.org/10.1016/j.modpat.2023.100145
Zhang W, Zeng W, Jiang A, He Z, Shen X, Dong X, et al. Global, regional and national incidence, mortality and disability-adjusted life-years of skin cancers and trend analysis from 1990 to 2019: An analysis of the Global Burden of Disease Study 2019. Cancer Med. 2021;10(14):4905-4922. DOI: https://doi.org/10.1002/cam4.4046
Ürün YG, Fiçicioğlu S, Ürün M, Can N. Clinical, dermoscopic and histopathological evaluation of basal cell carcinoma. Dermatol Pract Concept. 2023;13(1):1-11. DOI: https://doi.org/10.5826/dpc.1301a4
Behera B, Kumari R, Thappa DM, Gochhait D, Srinivas BH, Ayyanar P, et al. Dermoscopic features of basal cell carcinoma in skin of color: A retrospective cross-sectional study from Puducherry, South India. J Am Acad Dermatol. 2023;89(2):254-260. DOI: https://doi.org/10.25259/IJDVL_420_20
Șerbănescu MS, Bungărdean RM, Georgiu C, Crișan M. Nodular and micronodular basal cell carcinoma subtypes are different tumors based on their morphological architecture and their interaction with the surrounding stroma. Diagnostics (Basel). 2022;12(7):1636. DOI: https://doi.org/10.3390/diagnostics12071636
Saizan A, Taylor S, Elbuluk N. Pigmented basal cell carcinoma: An argument for sub-classification. J Drugs Dermatol. 2023;22(2):217-218. DOI: https://doi.org/10.36849/JDD.6883
Reiter O, Mimouni I, Dusza S, Halpern AC, Leshem YA, Marghoob AA. Dermoscopic features of basal cell carcinoma and its subtypes: A systematic review. J Am Acad Dermatol. 2021;85(3):653-664. DOI: https://doi.org/10.1016/j.jaad.2019.11.008
Adya KA, Inamadar AC, Palit A. Dermoscopic pigment network: Characteristics in non-melanocytic disorders. Indian Dermatol Online J. 2020;11:146-153. DOI: https://doi.org/10.4103/idoj.IDOJ_246_19
Kim RH, Armstrong AW. Non-melanoma skin cancer. Dermatol Clin. 2012;30:125-139. DOI: https://doi.org/10.1016/j.det.2011.08.008
Paolino G, Donati M, Didona D, Mercuri SR, Cantisani C. Histology of non-melanoma skin cancers: An update. Biomedicines. 2017;5(4):1-12. DOI: https://doi.org/10.3390/biomedicines5040071
Tímár J, Ladányi A. Molecular pathology of skin melanoma: Epidemiology, differential diagnostics, prognosis and therapy prediction. Int J Mol Sci. 2022;23(10):5384. DOI: https://doi.org/10.3390/ijms23105384
Rashid S, Shaughnessy M, Tsao H. Melanoma classification and management in the era of molecular medicine. Dermatol Clin. 2023;41(1):49-63. DOI: https://doi.org/10.1016/j.det.2022.07.017
Peris K, Fargnoli MC, Garbe C, Kaufmann R, Bastholt L, Seguin NB, et al. Diagnosis and treatment of basal cell carcinoma: European consensus-based interdisciplinary guidelines. Eur J Cancer. 2019;118:10-34. DOI: https://doi.org/10.1016/j.ejca.2019.06.003
Veldhuizen IJ, Budo J, Kallen EJJ, Sijben I, Hölscher MC, van der Hulst RRWJ, et al. A systematic review and overview of flap reconstructive techniques for nasal skin defects. Facial Plast Surg Aesthet Med. 2021;23(6):476-481. DOI: https://doi.org/10.1089/fpsam.2020.0533
Rao JK, Shende KS. Overview of local flaps of the face for reconstruction of cutaneous malignancies: Single institutional experience of seventy cases. J Cutan Aesthet Surg. 2016;9(4):220-225. DOI: https://doi.org/10.4103/0974-2077.197029
Patel PM, Greenberg JN, Kreicher KL, Burkemper NM, Bordeaux JS, Maher IA. Combination of melolabial interpolation flap and nasal sidewall and cheek advancement flaps allows for repair of complex compound defects. Dermatol Surg. 2018;44(6):785-795. DOI: https://doi.org/10.1097/DSS.0000000000001471
Gado SK, Karimnejad K, Maher IA, Gruber PJ, Walen S. Interpolated flaps. Facial Plast Surg. 2017;33(1):34-42. DOI: https://doi.org/10.1055/s-0037-1598170
Wald J, Tinklepaugh A, Husain Z, Ciocon D. Alar reconstruction after failure of an interpolated melolabial flap. Dermatol Surg. 2018;44(12):1623-1626. DOI: https://doi.org/10.1097/DSS.0000000000001595
Boyette JR. Reconstruction of a nasal alar defect, melolabial interpolation flap. In: Stack BC Jr, Moreno MA, Boyette JR, Vural EA, eds. Matrix Head and Neck Reconstruction. Springer; 2021:5-52.
Lukowiak TM, Perz AM, Veerabagu SA, Lee MP, Neal D, Aizman L, et al. Patient quality of life after interpolated flap repair of nasal Mohs surgery defects: A multicenter prospective cohort study. JAMA Dermatol. 2021;157(10):1213-1216. DOI: https://doi.org/10.1001/jamadermatol.2021.3161
Perz AM, Lukowiak TM, Lee MP, Neal D, Aizman L, Miller CJ, et al. Postoperative complications after interpolated flap repair for Mohs defects of the nose: A multicenter prospective cohort study. Dermatol Surg. 2023;49(2):135-139. DOI: https://doi.org/10.1097/DSS.0000000000003653
Chakraborty SS, Goel AD, Sahu RK, Midya M, Acharya S, Shakrawal N, et al. Effectiveness of nasolabial flap versus paramedian forehead flap for nasal reconstruction: A systematic review and meta-analysis. Aesthetic Plast Surg. 2023;47(1):313-329. DOI: https://doi.org/10.1007/s00266-022-03060-w
Ji J, Alexander N, Enin K, Spataro E. Factors associated with outcomes of facial reconstruction after Mohs micrographic surgery. Craniomaxillofac Trauma Reconstr. 2024;17(4):131-137. DOI: https://doi.org/10.1177/19433875241257981