Penetapan Kadar dan Uji Pelepasan Asam Salisilat pada Sediaan Nanogel Secara In Vitro
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Siti Fitria Ramadhani, Minda Sari Lubis, Zulmai Rani, Ainil Fithri Pulungan (2026). Penetapan Kadar dan Uji Pelepasan Asam Salisilat pada Sediaan Nanogel Secara In Vitro. Journal of Pharmaceutical and Sciences, JPS Volume 9 Nomor 4 (2026). https://doi.org/10.36490/journal-jps.com.v9i4.1873
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Salicylic acid is a keratolytic and comedolytic agent used in topical dermatological preparations. This study determined salicylic acid content and compared its in vitro release from a conventional gel and a nanogel formulation containing 1% salicylic acid. The nanogel was prepared by homogenization followed by ultrasonication, and particle size was measured instrumentally. Drug content was quantified by UV–visible spectrophotometry, whereas release was evaluated for 360 min using a dialysis membrane in a modified basket apparatus with phosphate buffer (pH 7.4). Mean salicylic acid content was 1.08205% in the conventional gel and 1.08492% in the nanogel; the reported nanogel particle size was 51 nm. At 360 min, cumulative drug release was 47.664% and 85.078%, respectively. Calibration yielded coefficients of determination (R²) of 0.999909 in ethanol and 0.999490 in phosphate buffer. The Higuchi equation gave the highest R² among the evaluated kinetic models (gel: 0.99359; nanogel: 0.99292). The nanogel showed higher cumulative release under the test conditions; however, the availability of only one release profile per formulation precluded inferential comparison and does not establish clinical superiority
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