Perbandingan Sediaan Sabun Cuci Tangan Cair Ekstrak Daun Sirih (Piper betle Linn) Dengan Dua Basis Asam Lemak Berbeda Sebagai Produk Antiseptik
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Rahmat Siregar, Ririn Anjelin, Sukma Oktafiani Putri, Fefri Perrianty (2026). Perbandingan Sediaan Sabun Cuci Tangan Cair Ekstrak Daun Sirih (Piper betle Linn) Dengan Dua Basis Asam Lemak Berbeda Sebagai Produk Antiseptik. Journal of Pharmaceutical and Sciences, JPS Volume 9 Nomor 4 (2026). https://doi.org/10.36490/journal-jps.com.v9i4.1982
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Botanical liquid hand soaps require a balance of physical quality and skin tolerability. This study compared liquid soaps containing ethanolic betel leaf (Piper betle L.) extract with olive oil (F1) or coconut oil (F2) as the lipid base. Maceration of 500 g dried leaves in 70% ethanol yielded 50 g extract (10%). Phytochemical screening identified alkaloids, flavonoids, tannins, saponins, and polyphenols. Each 100-mL formula contained 10 mL extract. Form, color, aroma, and indicator-based pH, five-minute foam retention, viscosity (three readings per formula), visual homogeneity, and short-term skin reactions were evaluated descriptively. Both were liquid and citrus-scented; F1 appeared darker. pH was 9 (F1) and 5 (F2). Foam retention was 93.77% and 64.63%, respectively; viscosity was 831.07 ± 6.11 and 914.83 ± 7.67 cP. F1 remained homogeneous after 15 minutes, whereas F2 exhibited phase separation. No edema, papules, or vesicles were observed in 10 volunteers over 30 minutes. F1 showed higher foam retention and initial homogeneity, whereas F2 was more viscous. Antiseptic efficacy, storage stability, and repeated-use skin safety require further assessment
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