Main Article Content

Fatin Shilvia
Anny Sartika Daulay
Ridwanto
Yayuk Putri Rahayu

Page: 520-535

Abstract

Currently, people are beginning to shift towards traditional medicine using natural ingredients. One of the medicinal plants is Yellow Wood (Arcangelisia flava (L.) Merr). Yellow wood has been proven to have antioxidant, antimalarial, antidepressant, antidiabetic, and anticancer activities. The purpose of this study is to determine the antioxidant activity of yellow wood by analyzing its IC50 value and to evaluate the toxicity of yellow wood extract by determining its LC50 value. In this study, the antioxidant activity of the extract was tested using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method, while the toxicity of yellow wood extract was assessed using the brine shrimp lethality test (BSLT) method with several concentration variants. The analysis of antioxidant activity in yellow wood using the 1,1-diphenyl-2-picrylhydrazyl method resulted in an IC50 value of 9.65 µg/ml, while vitamin C had an IC50 value of 3.96 µg/ml. Based on these results, both yellow wood and vitamin C fall into the category of very strong antioxidant activity. The probit analysis of the toxicity test of yellow wood extract using the brine shrimp lethality test method showed an LC50 value of 287.872 µg/ml, which is categorized as toxic. 

Downloads

Download data is not yet available.

Article Details

How to Cite
Shilvia, F., Daulay, A. S., Ridwanto, R., & Rahayu, Y. P. (2025). Antioxidant activity and toxicity test of yellow wood extract (Arcangelisia flava (L. Merr)). Journal of Pharmaceutical and Sciences, 8(1), 520–535. https://doi.org/10.36490/journal-jps.com.v8i1.776
Section
Original Articles

References

Sari P, Sugita P, Santoso A. Aktivitas antioksidan, antibakteri, dan toksisitas ekstrak kulit batang pohon kesambi (Schleichera oleosa (Lour) Oken). J Jamu Indones 2019;4:112–8. DOI: https://doi.org/10.29244/jji.v4i3.163

Suratno S, Rizki MI, Pratama MRF. In-vitro study of antioxidant activities from ethanol extracts of Akar Kuning (Arcangelisia flava). J Surya Med 2019;4. DOI: https://doi.org/10.33084/jsm.v4i2.594

Tariza AF. Uji Efek Inhibisi Ekstrak Etanol Daun Kayu Kuning (Arcangelisia flava (L.) Merr.) Terhadap Enzim Xantin Oksidase Secara In Vitro 2021.

Sawiji RT, La EOJ. Formulasi dan Uji Aktivitas Antioksidan Sediaan Body Butter Ekstrak Etanol Umbi Bit (Beta vulgaris L.) Dengan Metode DPPH. J Ilm Manuntung Sains Farm Dan Kesehat 2022;8:173–80. DOI: https://doi.org/10.51352/jim.v8i1.533

Yunita E, Sari DRAP. Aktivitas Antioksidan dan Toksisitas Fraksi Etil Asetat dan Fraksi N-Heksan Daun Pegagan (Centella Asiatica L.). J Mandala Pharmacon Indones 2022;8:58–66. DOI: https://doi.org/10.35311/jmpi.v8i1.167

Shinditya. Uji aktivitas antioksidan ekstrak etanol kulit kentang (Solanum tuberosum L.) dengan metode DPPH menggunakan Spektrofotometri Visible. universitas muslim nusantara al-washliyah Medan, 2021.

Ilmiah M, Anggarani MA, Mahfudhah DN. Literature Review of Antioxidant Activity of Several Types of Onions and Its Potential as Health Supplements. Indones J Chem Sci 2023;12:103–11.

Rachmawati E, Ulfa EU. Uji toksisitas subkronik ekstrak kayu kuning (Arcangelisia flava Merr) terhadap hepar dan ginjal. Glob Med Heal Commun 2018;6:1–6.

Indonesia DKR, Departemen Kesehatan Republik Indonesia, Departemen Kesehatan, Anonim. Materia Medika Indonesia Jilid VI. Jakarta Dep Kesehat Republik Indones 1978.

Molyneux P. The stable free radical diphenylpicrylhydrazyl (DPPH) is used to estimate antioxidant activity. Songklanakarin J Sci Technol 2004;26:211–9.

ASRA R, Azni NR, Rusdi R, Nessa N. Uji Aktivitas Antioksidan Ekstrak Etanol Fraksi Heksan, Fraksi Etil Asetat dan Fraksi Air Daun Kapulaga (Elettaria cardamomum (L.) Maton). J Pharm Sci 2019;2:30–7. https://doi.org/10.36490/journal-jps.com.v2i1.17. DOI: https://doi.org/10.36490/journal-jps.com.v2i1.17

Maulydya CE, Yuniarti R, Dalimunthe GI, Nasution HM. Analisis Aktivitas Antioksidan Teh Daun Jamblang (Syzygium Cumini (L.) Skeels) Dengan Metode DPPH (1, 1-Diphenyl-2-Picrylhydrazyl). Farmasainkes J Farm Sains, Dan Kesehat 2023;2:189–200. DOI: https://doi.org/10.32696/fjfsk.v2i2.1890

Febriani Y, Axyvia Q, Salman S. Formulasi Dan Uji Antioksidan Sediaan Face Mist Dari Ekstrak Etanol Buah Malaka (Phyllanthus emblica L.) Sebagai Pelembab Wajah. Forte J 2024;4:114–21. DOI: https://doi.org/10.51771/fj.v4i1.752

Afwa N. Fermentasi Seduhan Kopi Arabika Dengan Bakteri Lactoacillus Casei Dan Ragi Saccharomyces Cerevisiae Dan Uji Toksisitas. J Indah Sains Dan Klin 2021;2. https://doi.org/10.52622/jisk.v2i3.41. DOI: https://doi.org/10.52622/jisk.v2i3.41

Safriani L, Nasution MP, Nasution HM, Rahayu YP. Pengaruh Metode Ekstraksi Terhadap Efek Sitotoksisitas Daun Jamblang (Syzygium cumini L.) pada Larva Udang Artemia salina Leach Dengan Metode Brine Shrimp Lethality Test. FARMASAINKES J Farm SAINS, Dan Kesehat 2023;3:87–101.

Widyasari R, Yuspitasari D, Wildaniah W, Wahida RC. Uji Toksisitas Akut Ekstrak Metanol Kulit Buah Jeruk Sambal (Citrus microcarpa Bunge) Terhadap Larva Artemia salina L. Dengan Metode Brine Shrimp Lethality Test (BSLT). Med Sains J Ilm Kefarmasian 2018;3:51–8. DOI: https://doi.org/10.37874/ms.v3i1.64

Fadli F, Suhaimi S, Idris M. Uji Toksisitas Akut Ekstrak Etanol Daun Salam (Syzygium polyanthum (Wight) Walp.) Dengan Metode BSLT (Brine Shrimp Lethality Test). Med Sains J Ilm Kefarmasian 2019;4:35–42. DOI: https://doi.org/10.37874/ms.v4i1.121

Handayani S, Wirasutisna KR, Insanu M. Penapisan fitokimia dan karakterisasi simplisia daun jambu mawar (syzygium jambos alston). J Farm UIN Alauddin Makassar 2017;5:174–83.

Meyer BN, Ferrigno NR, Putnam JE, Jacobsen LB, Nichols DEJ, McLaughlin JL. Brine shrimp: a convenient general bioassay for active plant constituents. Planta Med 1982;45:31–4. DOI: https://doi.org/10.1055/s-2007-971236

Widiasriani IAP, Udayani NNW, Triansyah GAP, Dewi NPEMK, Wulandari NLWE, Prabandari AASS. Artikel Review: Peran Antioksidan Flavonoid dalam Menghambat Radikal Bebas. J Syifa Sci Clin Res 2024;6. DOI: https://doi.org/10.37311/jsscr.v6i2.27055

Dewi SR, Argo BD, Ulya N. Kandungan flavonoid dan aktivitas antioksidan ekstrak Pleurotus ostreatus. Rona Tek Pertan 2018;11:1–10. DOI: https://doi.org/10.17969/rtp.v11i1.9571

Ravishankar D, Rajora AK, Greco F, Osborn HMI. Flavonoids as prospective compounds for anti-cancer therapy. Int J Biochem Cell Biol 2013;45:2821–31. DOI: https://doi.org/10.1016/j.biocel.2013.10.004

Khan AU, Dagur HS, Khan M, Malik N, Alam M, Mushtaque MD. Therapeutic role of flavonoids and flavones in cancer prevention: Current trends and future perspectives. Eur J Med Chem Reports 2021;3:100010. DOI: https://doi.org/10.1016/j.ejmcr.2021.100010

Karak P. Biological activities of flavonoids: an overview. Int J Pharm Sci Res 2019;10:1567–74.

Wullur AC, Schaduw J, Wardhani ANK. Identifikasi alkaloid pada daun sirsak (Annona muricata L.). J Ilm Farm 2012;3:54–6.

Oktapiya TR, Pratama NP. Analisis fitokimia dan kromatografi lapis tipis ekstrak etanol daun rosella (Hibiscus sabdariffa L.). Sasambo J Pharm 2022;3:105–10. DOI: https://doi.org/10.29303/sjp.v3i2.181

Putri AP, Nasution MP. Skrining Fitokimia Dan Uji Sitotoksisitas Ekstrak Etanol Daun Tapak Dara (Catharanthus Roseus L.) Dengan Metode Brine Shrimp Lethality Test (Bslt). J Heal Med Sci 2022:203–19. DOI: https://doi.org/10.36490/journal-jps.com.v6i4.260

Putra GMD, Satriawati DA, Astuti NKW, Yadnya-Putra A. Standarisasi dan skrining fitokimia ekstrak etanol 70% daun jeruk limau (Citrus amblycarpa (Hassk.) Osche). J Kim 2018;12:187–94. DOI: https://doi.org/10.24843/JCHEM.2018.v12.i02.p15

Leonardy C, Nurmainah, Hafrizal R. Karakterisasi dan Skrining Fitokimia Infusa Kulit Buah Nanas ( Ananas comosus ( L .) Merr .) pada Variasi Usia Kematangan Buah. J Farm Sains Dan Prakt 2015;1:1–15.

Rubianti I, Azmin N, Nasir M. Analisis Skrining Fitokimia Ekstrak Etanol Daun Golka (Ageratum conyziodes) Sebagai Tumbuhan Obat Tradisional Masyarakat Bima. JUSTER J Sains Dan Terap 2022;1:7–12. DOI: https://doi.org/10.55784/juster.v1i2.67

Rachmani EPN, Pramono S, Nugroho AE. Aktivitas antioksidan fraksi flavonoid bebas andrografolid dari herba sambiloto (andrographis paniculata). J Farm Medica/Pharmacy Med J 2018;1. DOI: https://doi.org/10.35799/pmj.1.2.2018.21642

Rahmah R, Rahayu YP, Ridwanto R, Daulay AS. Skrining fitokimia dan uji aktivitas antioksidan ekstrak etanol daun alpukat (Persea americana Mill.) dengan metode DPPH. J Pharm Sci 2023:9–25. https://doi.org/10.36490/journal-jps.com.v6i5-si.369. DOI: https://doi.org/10.36490/journal-jps.com.v6i5-si.369

Suharyanto S, Prima DAN. Penetapan kadar flavonoid total pada juice daun ubi jalar ungu (Ipomoea batatas L.) yang berpotensi sebagai hepatoprotektor dengan metode spektrofotometri uv-vis. Cendekia J Pharm 2020;4:110–9. DOI: https://doi.org/10.31596/cjp.v4i2.89

Yanti R, Nasution MA, Ridwanto R, Nasution HM. Skrining fitokimia dan uji aktivitas antioksidan dari ekstrak etanol daun kedondong (Spondias dulcis Soland. ex Forst. fil) dengan metode DPPH. J Pharm Sci 2023:177–88. https://doi.org/10.36490/journal-jps.com.v6i5-si.377. DOI: https://doi.org/10.36490/journal-jps.com.v6i5-si.377

Nazirah N, Nasution MA, Ridwanto R, Nasution HM. Skrining fitokimia dan uji aktivitas antioksidan ekstrak metanol daun salam (Syzygium polyanthum (Wight.) Walp.) dari Gampong Bunot, Pidie Jaya dengan metode DPPH. J Pharm Sci 2023:104–16. https://doi.org/10.36490/journal-jps.com.v6i5-si.376. DOI: https://doi.org/10.36490/journal-jps.com.v6i5-si.376

Mulyani F, Rahayu YP, Daulay AS, Nasution HM. Phytochemical screening and antioxidant activity test of ethanol extract of Kasturi mango leaves (Mangifera Kasturi Koesterm.) from Darien Bungong village, Pidie Jaya, using the DPPH method. J Pharm Sci 2023:49–63. https://doi.org/10.36490/journal-jps.com.v6i5-si.374. DOI: https://doi.org/10.36490/journal-jps.com.v6i5-si.374

Meisa D. Potensi Antioksidan Kombinasi Ekstrak Daun Cocor Bebek (Kalanchoe pinnata L.) Dan Ekstrak Daun Kratom (Mitragyna speciosa Korth.) Dengan Metode DPPH 2024.

Salman S, Indriana M. Activity Ethanol Extract Of Mangga (Curcuma mangga Val.) Feet Udem Rat White. J Pharm Sci 2019;2:41–6. https://doi.org/10.36490/journal-jps.com.v2i2.83. DOI: https://doi.org/10.36490/journal-jps.com.v2i2.83

Asih DJ, Warditiani NK, Wiarsana IGS. Review artikel: Aktivitas antioksidan ekstrak Amla (Phyllanthus emblica/Emblica officinalis). Humantech J Ilm Multidisiplin Indones 2022;1:674–87.

Septiani R, Marianne M, Nainggolan M. Uji aktivitas antioksidan ekstrak etanol fraksi N-Heksan serta fraksi etil asetat daun jamblang (Syzygium cumini L. Skeels) dengan metode DPPH. Talent. Conf. Ser. Trop. Med., vol. 1, 2018, p. 361–6. DOI: https://doi.org/10.32734/tm.v1i2.217

Wahyuni S, Marpaung MP. Penentuan kadar alkaloid total ekstrak akar kuning (Fibraurea chloroleuca Miers) berdasarkan perbedaan konsentrasi etanol dengan metode spektrofotometri uv-vis. Dalt J Pendidik Kim Dan Ilmu Kim 2020;3. DOI: https://doi.org/10.31602/dl.v3i2.3911

Temarwut FF, Saharuddin M, Ishak P, Rusnah R. Uji Toksisitas Akut Ekstrak Air Buah Pare (Momordica Charantia L.) Terhadap Larva Udang (Artemia Salina Leach) Dengan Metode Brine Shrimp Lethally Test (Bslt). Fito Med J Pharm Sci 2022;13:77–83.

Masriyono M, Radityaningrum AD. Uji Toksisitas LC50 Air Limbah Restoran Cepat Saji Terhadap Biota Uji Ikan Nila Melalui Analisa Probabilitas Menggunakan Software Minitab. Pros. Semin. Teknol. Perencanaan, Perancangan, Lingkung. dan Infrastruktur, vol. 1, 2019, p. 459–64.

Reskianingsih A. Uji Toksisitas Akut Ekstrak Metanol Buah Phaleria macrocarpa (Scheff) Boerl Terhadap Larva Artemia salina Leach Dengan Metode Brine Shrimp Lethality Test (BSLT) 2014.

Zulfiah Z, Megawati M, Herman H, Lau SHA, Hasyim MF, Murniati M, et al. uji Toksisitas Ekstrak Rimpang Temu Hitam (Curcuma aeruginosa Roxb.) Terhadap Larva Udang (Artemia salina Leach) Dengan Metode Brine Shrimp Lethality Test (BSLT). J Farm Sandi Karsa 2020;6:44–9. DOI: https://doi.org/10.36060/jfs.v6i1.67

McLaughlin JL, Rogers LL, Anderson JE. The use of biological assays to evaluate botanicals. Drug Inf J 1998;32:513–24. DOI: https://doi.org/10.1177/009286159803200223

Adriana ANI. Uji Lc50 Ekstrak Batang Akar Kuning (Arcangelisia Flava Merr) Terhada Larva Udang (Arthemia Salina Leach) Dengan Metode BSLT (Brine Shrimp Lethality Test). Pharmacol Pharm Sci Journals 2023;2:9–16. https://doi.org/10.51577/papsjournals.v2i1.416. DOI: https://doi.org/10.51577/papsjournals.v2i1.416

Naher S, Aziz MA, Akter MI, Rahman SMM, Sajon SR, Mazumder K. Anti-Diarrheal Activity and Brine Shrimp Lethality Bioassay of Methanolic Extract of Cordyline fruticosa (L.) A. Chev. Leaves. Clin Phytoscience 2019;5. https://doi.org/10.1186/s40816-019-0109-z. DOI: https://doi.org/10.1186/s40816-019-0109-z

Naritasari F, Susanto H, Supriatno S. The Effect Of Pineapple Stem Ethanol Extract Of (Ananas comosus (L.) To Apoptosis Of Oral Tongue Squamous Cell Carcinoma Cell Line. Maj Obat Tradis n.d.;15:16–25.

Subekti NK. Uji toksisitas akut ekstrak metanol daun laban abang (aglaia elliptica blume) terhadap larva udang (artemia salina leach) dengan metode Brine Shrimp Lethality Test (BSLT) 2014.

Sari MP, Nugroho LH, Sukarno S. Effectiveness of N-Hexane and Ethanol Extract of Papaya (Carica Papaya L.) Leaves as Shallot Pest (Spodoptera Exigua Hübner) Natural Insecticide. J Biol Udayana 2022;26:216. https://doi.org/10.24843/jbiounud.2022.v26.i02.p07. DOI: https://doi.org/10.24843/JBIOUNUD.2022.v26.i02.p07

Kumar D, Roy R, Parashar A, Raichur AM, Chandrasekaran N, Mukherjee A, et al. Toxicity Assessment of Zero Valent Iron Nanoparticles on Artemia Salina. Environ Toxicol 2017;32:1617–27. https://doi.org/10.1002/tox.22389. DOI: https://doi.org/10.1002/tox.22389

Giacco F, Brownlee M. Oxidative Stress and Diabetic Complications. Circ Res 2010;107:1058–70. https://doi.org/10.1161/circresaha.110.223545. DOI: https://doi.org/10.1161/CIRCRESAHA.110.223545

James RJ, Halim H, Nasir MMA, Amiruddin FH, Hazalin NAMN. Protective Effect of Carica Papaya Leaves Against Oxidative Stress in Brine Shrimps. Int J Public Heal Sci 2023;12:1070. https://doi.org/10.11591/ijphs.v12i3.22494. DOI: https://doi.org/10.11591/ijphs.v12i3.22494

Keller AA, Garner KL, Miller RJ, Lenihan HS. Toxicity of Nano-Zero Valent Iron to Freshwater and Marine Organisms. PLoS One 2012;7:e43983. https://doi.org/10.1371/journal.pone.0043983. DOI: https://doi.org/10.1371/journal.pone.0043983

Zhu S, Xue M, Luo F, Chen W, Zhu B, Wang G. Developmental Toxicity of Fe 3 O 4 Nanoparticles on Cysts and Three Larval Stages of Artemia Salina. Environ Pollut 2017;230:683–91. https://doi.org/10.1016/j.envpol.2017.06.065. DOI: https://doi.org/10.1016/j.envpol.2017.06.065

Tridiptasari A, Leksono AS, Siswanto D. Antifeedant Effect of Moringa Oleifera (L.) Leaf and Seed Extract on Growth and Feeding Activity of Spodoptera Litura (Fab.) (Lepidoptera: Noctuidae). J Exp Life Sci 2019;9:25–31. https://doi.org/10.21776/ub.jels.2019.009.01.05. DOI: https://doi.org/10.21776/ub.jels.2019.009.01.05

BSLT LT. Penapisan Fitokimia dan Uji Toksisitas Akut Ekstrak Metanol Beberapa Tanaman Obat Terhadap Larva Udang Artemia salina Leach n.d.

Most read articles by the same author(s)

1 2 3 4 5 > >>