Hubungan Status Gizi dan Kekambuhan Tuberkulosis di Balai Besar Kesehatan Paru Masyarakat Surakarta
Bilah Samping Artikel
Isi Artikel Utama
Page: 960-966
Abstrak
Penurunan status gizi dapat melemahkan sistem kekebalan tubuh sehingga meningkatkan risiko infeksi Mycobacterium tuberculosis. Tujuan dari penelitian ini adalah untuk mengetahui risiko kekambuhan tuberkulosis (TB) yang dikaitkan dengan status gizi pasien TB. Penelitian ini dilakukan di Balai Besar Kesehatan Paru Masyarakat Surakarta pada tahun 2017 dengan rancangan penelitian case control. Terdapat 15 orang dalam kelompok kontrol (pasien TB yang sembuh) dan 15 orang pada kelompok kasus (pasien TB yang mengalami kekambuhan TB). Kriteria inklusi dalam penelitian ini adalah pasien TB berusia 18-65 tahun, baik laki-laki maupun perempuan, yang telah menyelesaikan pengobatan TB secara penuh, serta pasien yang memiliki data lengkap mengenai status gizi yang diukur melalui Indeks Massa Tubuh (IMT) dan asupan gizi yang tercatat dalam rekam medis. Pasien juga harus tidak memiliki gangguan metabolik atau penyakit kronis selain TB yang dapat mempengaruhi status gizi. Data diambil dari rekam medis dan diolah menggunakan SPSS versi 25. Hasil penelitian menunjukkan bahwa pasien dengan status gizi yang buruk (di bawah IMT normal) memiliki risiko lebih tinggi untuk mengalami kekambuhan tuberkulosis (p = 0,028). Temuan lain menunjukkan bahwa pasien yang memiliki kebiasaan mengonsumsi alkohol juga memiliki potensi kekambuhan TB yang lebih tinggi (p = 0,001). Kesimpulan dari penelitian ini adalah status gizi yang buruk berperan dalam terjadinya kekambuhan tuberkulosis.
Unduhan
Rincian Artikel
Artikel ini berlisensiCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Referensi
WHO, Tuberculosis Report 2023, World Health Organization, 2023.
D. N. McMurray and J. P. Cegielski, "The Relationship Between malnutrition and Tuberculosis: Evidence from global and local prespective.," Clinical Microbiology Reviews, Vols. 34-3, no. e00222-20, 2021.
M. van Lettow, w. w. Fawzi and R. D. Semba, "Nutritional Supllementation during Tuberculosis treatment: Meta Analysis.," The Lancet Global Health, vol. 8, no. 1, pp. 59-69, 2020.
R. S. dewi and E. Purwanti, "Nutritional Status as a Predictor of Tuberculosis treatment Outcomes: A study in Indonesia," Asia Pasific Journal of Clinical Nutrition, vol. 30, no. 4, pp. 755-762, 2021.
R. handayani and E. Setiawan, "Role of Vitamin D and Iron Deficiency in Recurrent Tuberculosis Cases," Journal of Clinical Nutrition , vol. 25, no. 3, pp. 321-330, 2021.
S. Nhamoyebonde and A. Leslie, "Biological Differences Between The Sexes an Supectibility to Tuberculosis," J Infect Dis, vol. 209, no. 3, pp. 100-106, 2014. DOI: https://doi.org/10.1093/infdis/jiu147
K. Horton, P. MacPherson , R. Houben and E. Corbett , "Sex Differences in Tuberculosis Burden and Notifications in Low an Middle Income Countries," PLoS Med, vol. 13, no. 9, 2016. DOI: https://doi.org/10.1371/journal.pmed.1002119
WHO, "Global Tuberculosis Report 2020," World Health Organization, 2020.
O. Neyrolles and L. Quintana-Murci, "Sexual Inequality in Tuberculosis," PLoS Med, vol. 6, no. 12, 2019. DOI: https://doi.org/10.1371/journal.pmed.1000199
A. Prentice, "Testosterone and the immune system: implications for infection and immunity.," J Endocrinol., p. 10, 2012.
Mauvais-Jarvis F, "Estrogen and the immune response to tuberculosis.," Curr Opin Rheumatol., 2012.
Mishra S, "Gender differences in healthcare seeking behavior and TB treatment adherence in developing countries.," Trop Med Int Health., 2017.
Namusoke, "Malnutrition and Unsucceful tuberculosis treatment among people with multi drug resistant tuberculosis in Uganda," International Journal of Tuberculosis and Lung DIsease, vol. 27, no. 7, pp. 572-579, 2023.
WHO, "Tuberculosis and Malnutrition Factsheet," World Healt Organization, 2024.
S. Ahuja, "Management of Malnutrition in Tuberculosis Patients: A Systematic Review.," Tuberculosis Research and Treatment., 2019.
Dooley K. E., & Blumberg, H. M., "Pharmacokinetics and Pharmacodynamics of Antituberculosis Drugs.," Seminars in Respiratory and Critical Care Medicine, 2004.
Viswanathan, V., et al. "Effect of Malnutrition on the Pharmacokinetics of Anti-Tuberculosis Drugs.," European Respiratory Journal, 2008.
H. Lee, "Sex Differences in the Impact of Diabetes Mellitus on Tuberculosis Recurrences," International Journal of Infectious Diseases, vol. 122, pp. 712-718, 2022.
B. I. Restrepo, "Diabetes Mellitus and Tuberculosis.," Endocrinology and Metabolism Clinics of North America, vol. 45, no. 2, pp. 405-426, 2016. DOI: https://doi.org/10.1016/j.ecl.2016.01.005
P. Huangpu, "The Effects of Diabetes on Tuberculosis Treatment Outcomes: an Updates Systematic Review an Meta Analysis," BMC Medicine, vol. 18, no. 3, p. 203, 2020.
M. Ibrahim, "The Impact of Smoking on Pulmonary Tuberculosis Treatment Outcomes," Journal of Pulmonary Health Research, vol. 7, no. 2, pp. 45-53, 2019.
N. S, "The Effect of Cigarette Smoke on the Immune Response in Tuberculosis Patients," Indonesian Journal of Respiratory Medicine, vol. 12, no. 1, pp. 27-35, 2015.
C. P. Chaulk and P. K. Moonan, "Alcohol Use and Tuberculosis: A Dangerous Partnership.," Center Control and Prevention (CDC), 2020.