Tren Penelitian Global dalam Model Kanker Payudara Tiga Dimensi: Analisis Bibliometrik (2007–2025)
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Latar belakang: Model kultur tiga dimensi (3D) telah muncul sebagai platform praklinis yang menjanjikan untuk penelitian kanker payudara karena model ini lebih baik dalam meniru lingkungan mikro tumor (TME) kultur dua dimensi konvensional. Seiring dengan kemajuan dalam rekayasa jaringan, penelitian terkait model 3D telah berkembang pesat, sehingga memerlukan evaluasi komprehensif terhadap tren penelitian global. Metode: Analisis bibliometrik dilakukan menggunakan basis data Scopus yang mencakup publikasi dari tahun 2007 hingga 2025, dan hanya menyertakan artikel penelitian asli. Indikator bibliometrik, termasuk produksi ilmiah tahunan, negara-negara terkemuka, institusi, penulis, jurnal, publikasi yang banyak dikutip dan pola kolaborasi, dianalisis menggunakan Biblioshiny (R packet), sementara kemunculan bersama kata kunci dan evolusi temporal divisualisasikan menggunakan VOSviewer. Hasil: Sebanyak 207 artikel penelitian yang diterbitkan oleh 1.245 penulis dianalisis. Produksi ilmiah menunjukkan tingkat pertumbuhan tahunan yang konsisten sebesar 13,32%, yang mencerminkan peningkatan minat global pada pemodelan kanker payudara tiga dimensi. Amerika Serikat merupakan kontributor utama dalam produktivitas publikasi dan dampak ilmiah, sedangkan Biomaterials adalah jurnal yang paling produktif. Publikasi yang banyak dikutip sebagian besar berfokus pada teknologi rekayasa jaringan tingkat lanjut, termasuk bioprinting, hidrogel, rekayasa matriks ekstraseluler dan mikrofluida. Analisis co-occurence kata kunci mengidentifikasi tujuh klaster tematik, sementara visualisasi overlay mengungkapkan pergeseran penelitian dari kultur sel 3D konvensional menuju pendekatan rekayasa jaringan yang lebih canggih, khususnya pada aspek biomaterial, rekonstruksi lingkungan mikro tumor, skrining obat dan pengobatan presisi. Kesimpulan: Penelitian tentang model kanker payudara 3D telah berkembang menjadi bidang multidisiplin yang didorong oleh inovasi rekayasa jaringan. Studi ini memberikan peta pengetahuan komprehensif tentang bidang ini, menyoroti arah penelitian yang muncul dan menawarkan panduan berharga untuk kolaborasi interdisipliner di masa depan dan pengembangan model kanker payudara in vitro yang relevan secara fisiologis.
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