Efektivitas Terapi Antikoagulan terhadap Parameter Koagulasi pada Pasien Stroke Iskemik: Studi Retrospektif di RSUP Dr. M. Djamil Padang
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Pendahuluan: Stroke iskemik merupakan penyebab utama morbiditas dan mortalitas global, dengan terapi antikoagulan menjadi pilihan utama untuk pencegahan sekunder pada kasus tertentu. Namun, bukti ilmiah mengenai efektivitas terapi antikoagulan pada populasi Indonesia masih terbatas. Tujuan: Mengevaluasi efektivitas terapi antikoagulan berdasarkan perubahan parameter koagulasi (PT, APTT, INR) dan hubungannya dengan luaran klinis pada pasien stroke iskemik di RSUP Dr. M. Djamil Padang. Metode: Studi observasional analitik retrospektif melibatkan 68 pasien stroke iskemik yang menerima antikoagulan (Januari–Desember 2024). Efektivitas dinilai dari perubahan PT, APTT, dan INR sebelum dan sesudah terapi menggunakan uji Wilcoxon dan Kruskal-Wallis. Hasil: Terapi antikoagulan meningkatkan PT, APTT, dan INR secara signifikan pada sebagian besar kelompok (p<0,05), tanpa perbedaan signifikan antar jenis antikoagulan (p>0,05). Pasien dengan luaran meninggal menunjukkan peningkatan parameter koagulasi yang lebih tinggi, namun hubungan signifikan hanya ditemukan pada perubahan APTT (p=0,033). Kesimpulan: Terapi antikoagulan efektif memengaruhi parameter koagulasi pada pasien stroke iskemik, dan peningkatan APTT setelah terapi berhubungan dengan mortalitas. Penelitian prospektif lebih lanjut diperlukan untuk mengonfirmasi temuan ini.
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