Sintesis Nanopartikel Minyak Atsiri Gardenia Menggunakan Lapisan Pelindung PolimerPeg-40 Hydrogenated Castor Oil Dan Karakterisasinya
Bilah Samping Artikel
Isi Artikel Utama
Page: 1697-1710
Abstrak
Penelitian ini berfokus pada pembuatan nanoemulsi minyak atsiri Gardenia menggunakan surfaktan PEG-40 Hydrogenated Castor Oil (PEG-40 HCO) melalui metode atomisasi untuk menilai pengaruh variasi jumlah minyak terhadap karakteristik fisik dan sifat elektrokinetik sistem yang terbentuk. Empat volume minyak, yaitu 4, 6, 8, dan 10 mL dalam 80 mL air, digunakan sebagai prekursor, kemudian dianalisis untuk menentukan ukuran partikel, indeks polidispersitas (PDI), mobilitas elektroforetik, dan nilai zeta potensial. Hasil menunjukkan bahwa peningkatan konsentrasi minyak memberikan kecenderungan pembesaran diameter rata-rata partikel. Nilai PDI yang diperoleh relatif rendah, namun interpretasinya dilakukan secara hati-hati karena sistem menunjukkan distribusi ukuran partikel bimodal. Nilai zeta potensial berkisar antara -2,3 hingga -7,8 mV, sedangkan mobilitas elektroforetik berada pada rentang -0,000017 hingga -0,000060 cm²/Vs. Hasil tersebut menunjukkan adanya perubahan karakteristik permukaan partikel seiring peningkatan konsentrasi minyak atsiri. Karakteristik nanoemulsi yang terbentuk mengindikasikan adanya peran PEG-40 HCO dalam pembentukan dan dispersi tetesan minyak dalam medium air. Secara keseluruhan, penelitian ini menunjukkan bahwa PEG-40 HCO berpotensi digunakan dalam pembentukan nanoemulsi minyak atsiri Gardenia dengan ukuran partikel pada rentang nanometer dan distribusi ukuran yang relatif baik, sehingga berpotensi untuk dikembangkan lebih lanjut pada formulasi parfum berbasis air maupun aplikasi kosmetik lainnya. Namun, evaluasi kestabilan jangka panjang sistem masih memerlukan pengujian stabilitas lebih lanjut.
Unduhan
Rincian Artikel
Artikel ini berlisensiCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Referensi
Herdiana Y. Alcohol in Daily Products: Health Risks, Cultural Considerations, and Economic Impacts. Risk Manag Healthc Policy 2025;Volume 18:217–37. https://doi.org/10.2147/RMHP.S495493.
Sabrina LM, Zahra AA, Aini KN, Rafifa M, Maulida VS, Putra HE. Analisis Komparatif Surfaktan dan Kosurfaktan serta Parameter Fisik Dalam Formulasi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Berbasis Tanaman Herbal. Jurnal Ilmiah Respati 2025;16:63–74.
Adeyemi SB, Akere AM, Orege JI, Ejeromeghene O, Orege OB, Akolade JO. Polymeric nanoparticles for enhanced delivery and improved bioactivity of essential oils. Heliyon 2023;9:e16543. https://doi.org/10.1016/j.heliyon.2023.e16543.
Buriti BMA de B, Figueiredo PLB, Passos MF, da Silva JKR. Polymer-Based Wound Dressings Loaded with Essential Oil for the Treatment of Wounds: A Review. Pharmaceuticals 2024;17:897. https://doi.org/10.3390/ph17070897.
Winarti RS, Saragih H. Pengaruh Penyimpanan dan Pemanasan Terhadap Perubahan Ukuran Nanopartikel Parfum Campuran Minyak Royal Musk dan Minyak Atsiri Lili yang Disintesis Menggunakan Surfaktan Polimer PEG-40 HCO. Jurnal Fisika Unand 2025;14:516–25. https://doi.org/10.25077/jfu.14.5.516-525.2025.
Kumar M, Chauhan N, Kumar D, Mahmood S, Chopra S, Bhatia A. Revolutionizing nanomedicine: Expanding horizons of nanoemulsions in drug delivery and beyond. J Dispers Sci Technol 2024:1–26. https://doi.org/10.1080/01932691.2024.2369835.
Jacob S, Kather FS, Boddu SHS, Shah J, Nair AB. Innovations in Nanoemulsion Technology: Enhancing Drug Delivery for Oral, Parenteral, and Ophthalmic Applications. Pharmaceutics 2024;16:1333. https://doi.org/10.3390/pharmaceutics16101333.
Rachmawati H, Novel M, Ayu S, Berlian G, Tandrasasmita O, Tjandrawinata R, et al. The In Vitro–In Vivo Safety Confirmation of PEG-40 Hydrogenated Castor Oil as a Surfactant for Oral Nanoemulsion Formulation. Sci Pharm 2017;85:18. https://doi.org/10.3390/scipharm85020018.
Daneshmand H, Sazgar A, Araghchi M. Fabrication of robust and versatile superhydrophobic coating by two-step spray method: An experimental and molecular dynamics simulation study. Appl Surf Sci 2021;567:150825. https://doi.org/10.1016/j.apsusc.2021.150825.
Marquez R, Ontiveros JF, Barrios N, Tolosa L, Palazzo G, Nardello‐Rataj V, et al. Advantages and limitations of different methods to determine the optimum formulation in surfactant–oil–water systems: A review. J Surfactants Deterg 2024;27:5–36. https://doi.org/10.1002/jsde.12703.
Singh PK, Joshi D, Mandal A, Pal N. Silica Nanoparticle-Stabilized Anionic Surfactant Microemulsions: Characterization, Technical Evaluation, and Core-Flooding Studies for Enhanced Oil Recovery. Energy & Fuels 2025;39:1870–88. https://doi.org/10.1021/acs.energyfuels.4c05091.
Goswami AS, Rawat R, Pillai P, Saw RK, Joshi D, Mandal A. Formulation and characterization of nanoemulsions stabilized by nonionic surfactant and their application in enhanced oil recovery. Pet Sci Technol 2024;42:2990–3008. https://doi.org/10.1080/10916466.2023.2181357.
Putra AAGSP, Suhendra L, IAnggreni AAMD. Stabilitas Dan Ukuran Partikel Mikroemulsi Minyak Atsiri Sereh (Cymbopogon Citratus) Dengan Rasio Surfaktan Dan Ko-Surfaktan. JURNAL REKAYASA DAN MANAJEMEN AGROINDUSTRI 2025;13:196–204. https://doi.org/10.24843/JRMA.2025.v13.i02.p05.
Kurchavov D, Rustambek U, Haddad M, Ottochian A, Lefèvre G, Ciofini I, et al. Influence of PEG-containing cation on molecular state of water in water – Acetate based ionic liquids mixtures. J Mol Liq 2022;367:120564. https://doi.org/10.1016/j.molliq.2022.120564.
Pochapski DJ, Carvalho dos Santos C, Leite GW, Pulcinelli SH, Santilli CV. Zeta Potential and Colloidal Stability Predictions for Inorganic Nanoparticle Dispersions: Effects of Experimental Conditions and Electrokinetic Models on the Interpretation of Results. Langmuir 2021;37:13379–89. https://doi.org/10.1021/acs.langmuir.1c02056.
Hunter SJ, Penfold NJW, Chan DH, Mykhaylyk OO, Armes SP. How Do Charged End-Groups on the Steric Stabilizer Block Influence the Formation and Long-Term Stability of Pickering Nanoemulsions Prepared Using Sterically Stabilized Diblock Copolymer Nanoparticles? Langmuir 2020;36:769–80. https://doi.org/10.1021/acs.langmuir.9b03389.
Tran E, Richmond GL. Interfacial Steric and Molecular Bonding Effects Contributing to the Stability of Neutrally Charged Nanoemulsions. Langmuir 2021;37:12643–53. https://doi.org/10.1021/acs.langmuir.1c02020.
Artiga-Artigas M, Montoliu-Boneu J, Salvia-Trujillo L, Martín-Belloso O. Factors affecting the formation of highly concentrated emulsions and nanoemulsions. Colloids Surf A Physicochem Eng Asp 2019;578:123577. https://doi.org/10.1016/j.colsurfa.2019.123577.
Dajic Stevanovic Z, Sieniawska E, Glowniak K, Obradovic N, Pajic-Lijakovic I. Natural Macromolecules as Carriers for Essential Oils: From Extraction to Biomedical Application. Front Bioeng Biotechnol 2020;8. https://doi.org/10.3389/fbioe.2020.00563.
Aisyah N, Sriwidodo S, Husni P, Sinala S. Analisis Aktivitas Antioksidan Nanoemulsi Berbaris Tanaman dalam Aplikasi Farmasi dan Kosmetik : Kajian Literatur. Media Kesehatan Politeknik Kesehatan Makassar 2025;20:139–52. https://doi.org/10.32382/medkes.v20i1.1458.