Eksplorasi Efek Hidrasi Lotion Yang Diperkaya Dengan Ekstrak Clitoria Ternatea Pada Kulit Mus Musculus Yang Terpapar Sinar UV
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Penelitian ini bertujuan untuk mengevaluasi efektivitas lotion yang diperkaya ekstrak bunga telang (Clitoria ternatea) dalam meningkatkan hidrasi kulit mencit (Mus musculus) yang terpapar sinar ultraviolet (UV). Ekstrak bunga telang diketahui memiliki kandungan antosianin dan senyawa fenolik yang berperan sebagai antioksidan dan diduga mampu mempertahankan kelembapan kulit. Desain penelitian menggunakan metode eksperimental. Tikus secara acak dibagi menjadi lima kelompok (n = 6 per kelompok), yang terdiri dari kelompok kontrol negatif, kelompok kontrol positif, dan tiga kelompok perlakuan yang menerima losion ekstrak bunga telang dengan konsentrasi 0,5%, 1%, dan 2%. Tingkat hidrasi kulit diukur menggunakan Scalar Moisture Checker setelah lima menit terpapar sinar UV. Hasil menunjukkan perbedaan signifikan dalam tingkat hidrasi antar kelompok. Losion ekstrak bunga telang 1% menunjukkan peningkatan hidrasi kulit yang signifikan dibandingkan dengan kontrol negatif (p < 0,05), menunjukkan efektivitas pelembap optimal di antara formulasi yang diuji. Temuan ini menunjukkan bahwa ekstrak bunga telang berpotensi sebagai bahan aktif dalam formulasi lotion untuk meningkatkan hidrasi kulit yang mengalami kerusakan akibat paparan sinar UV. Penelitian ini memberikan dasar ilmiah dalam pemanfaatan ekstrak bunga telang sebagai agen pelembap alami.
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Referensi
] Badan Meteorologi, Klimatologi, dan Geofisika (BMKG). (2023). Peringatan dini indeks ultraviolet. Available at: https://www.bmkg.go.id .
] Kementerian Kesehatan Republik Indonesia. (2022). Laporan nasional data kanker kulit di Indonesia.
] Puri, P., Nandar, S.K., Kathuria, S., dan Ramesh, V. (2017). Effects of air pollution on the skin: a review. Indian Journal of Dermatology, Venereology, and Leprology, 83(4), pp. 415–423. DOI: https://doi.org/10.4103/0378-6323.199579
] Roh, E., Kim, J.-E., Kwon, J.Y., Park, J.S., Bode, A.M., Dong, Z., dan Lee, K.W. (2017). Molecular mechanisms of green tea polyphenols with protective effects against skin photoaging. Critical Reviews in Food Science and Nutrition, 57(8), pp. 1631–1637. DOI: https://doi.org/10.1080/10408398.2014.1003365
] D’Orazio, J., Jarrett, S., Amaro-Ortiz, A., dan Scott, T. (2013). UV radiation and the skin. International Journal of Molecular Sciences, 14(6), pp. 12222–12248. DOI: https://doi.org/10.3390/ijms140612222
] American Academy of Dermatology (AAD). (2023). Sunscreen FAQs. Available at: https://www.aad.org/public/everyday-care/sun-protection/sunscreen-patients/sunscreen-faqs .
] World Health Organization (WHO). (2022). Sun protection. Available at: https://www.who.int/news-room/questions-and-answers/item/radiation-ultraviolet-(uv)
] International Agency for Research on Cancer (IARC). (2020). Radiation - ultraviolet (UV). World Health Organization. Available at: https://www.iarc.who.int/ .
] Saritani, A.T.B., Wiraguna, A.A.G.P. and Maker, L.P.I.I. (2021). Clitoria ternatea L. extract cream 5% inhibits the increase of MMP-1 levels and decrease of collagen amount in Wistar rats (Rattus norvegicus) dermic skin exposed to ultraviolet B. Neurologico Spinale Medico Chirurgico, 4(3), pp. 109–113. DOI: https://doi.org/10.36444/nsmc.v4i3.183
] Roh, S.S. et al. (2019) 'Clinical efficacy of herbal extract cream on the skin hydration, elasticity, and dermal density', Dermatol Ther. DOI: https://doi.org/10.1111/jocd.12846
] Fitrilia, T., Kurniawan, M.F., Kurniawati, F.R., dan Setiawan, T. (2020). The potential of butterfly pea flower methanol extract as an antioxidant by in silico. Indonesian Journal of Applied Research (IJAR), 1(3), pp. 163–169. DOI: https://doi.org/10.30997/ijar.v1i3.64
] Nair, V., Bang, W.Y., Schreckinger, E., Andarwulan, N., dan Cisneros-Zevallos, L. (2015). Protective role of ternatin anthocyanins and quercetin glycosides from butterfly pea (Clitoria ternatea Leguminosae) blue flower petals against lipopolysaccharide (LPS)-induced inflammation in macrophage cells. Journal of Agricultural and Food Chemistry, 63(28), pp. 6355–6365. DOI: https://doi.org/10.1021/acs.jafc.5b00928
] Mahardika, M.P. and Purgiyanti. (2024). Formulasi dan uji stabilitas sediaan gel moisturizer bunga telang (Clitoria ternatea L.). Parapemikir: Jurnal Ilmiah Farmasi, 13(1), pp. 138–145. Available at: https://ejournal.poltekharber.ac.id/index.php/parapemikir/article/view/6543 DOI: https://doi.org/10.30591/pjif.v13i1.6543
] Purnamawati, S., Indrastuti, N., Danarti, R. and Saefudin, T. (2017) 'The Role of Moisturizers in Addressing Various Kinds of Dermatitis: A Review', Clinical Medicine & Research, 15(3-4), pp. 75-87. DOI: https://doi.org/10.3121/cmr.2017.1363
] Kang, H., Kim, S., Lee, J. and Oh, W. (2019) 'The Mechanism of Action of Emollients and Humectants in Moisturizing Creams', Journal of Dermatological Science, 93(1), pp. 12-17.
] Chen, X., Wang, Z. and Li, W. (2022) 'Glycerol: A Comprehensive Review on Its Role in Skin Hydration and Barrier Function', Journal of Cosmetic Science, 73(1), pp. 45-58.
] Thring, T.S., Hili, P. and Naughton, D.P. (2009) 'Antioxidant and potential anti-inflammatory activity of extracts and formulations of white tea, rose, and witch hazel on primary human dermal fibroblast cells', Journal of Inflammation, 8(1), p. 27. DOI: https://doi.org/10.1186/1476-9255-8-27
] Xie, M. (2024) 'Application of plant extracts cosmetics in moisturizing and anti-aging', Int. J. Cosmet. Sci. DOI: https://doi.org/10.1016/j.jdsct.2024.100014
] Thonthula, S. et al. (2024) 'Improved Skin Barrier Function Along with Hydration from Plant Extracts', Pharmaceutics.
] Draelos, Z.D. (2018) 'The Science behind Skin Care: Moisturizers', Journal of Cosmetic Dermatology, 17(2), pp. 138-144. DOI: https://doi.org/10.1111/jocd.12490
] Mukherjee, P.K., Maity, N., Nema, N.K. and Sarkar, B.K. (2011) 'Bioactive Compounds from Natural Resources against Skin Aging', Phytomedicine, 19(1), pp. 64-73. DOI: https://doi.org/10.1016/j.phymed.2011.10.003