Peningkatan Efek Antiinflamasi Multikomponen Etorikoksib terhadap Penurunan TNF-α
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Etorikoksib merupakan suatu inhibitor COX-2 selektif, digunakan karena efek antiinflamasinya, tetapi memiliki efek samping yang bergantung pada dosis. Formulasi multikomponen dengan koformer menawarkan strategi potensial untuk meningkatkan efikasi dan mungkin dapat meminimalkan toksisitas. Penelitian ini bertujuan untuk mengevaluasi efikasi antiinflamasi etorikoksib murni dan formulasi multikomponennya dengan nikotinamida, N-metil glukamine, dan piperin menggunakan TNF-α sebagai koformer. Eksperimen laboratorium terkontrol dilakukan pada tikus Wistar menggunakan model kantong granuloma yang diinduksi karagenan. Kadar TNF-α diukur pada awal (0 jam) dan 6 jam pascaperawatan. Uji normalitas, ANOVA dua arah, dan analisis post-hoc Tukey HSD diterapkan untuk menilai perbedaan kelompok dan efek waktu. Semua kelompok perlakuan mengalami penurunan kadar TNF-α secara signifikan dibandingkan dengan kontrol (p < 0,001). Meskipun perbandingan berpasangan antar perlakuan tidak signifikan secara statistik, formulasi P4 (etorikoksib–piperin) menunjukkan penurunan yang paling konsisten. P3 (etorikoksib–N-metil glukamine) menunjukkan perbedaan yang hampir signifikan dari etorikoksib murni (P1), menunjukkan peningkatan efikasi. Efek utama waktu mengonfirmasi penurunan temporal TNF-α (p = 0,0101), tanpa interaksi kelompok × waktu yang signifikan. Multikomponen, terutama dengan koformer piperin dan N-metil glukamine, meningkatkan efek antiinflamasi etorikoksib. Penelitian ini mendukung pengembangan lebih lanjut etorikoksib yang ditingkatkan secara biologis sebagai alternatif yang lebih baik sebagai antiinflamasi.
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