Pengaruh Pemberian Ekstrak Etanol Daun Etlingera comosa terhadap penurunan kadar glukosa darah dan gambaran histopatologi pankreas tikus putih jantan
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Etlingera comosa merupakan jenis tanaman endemik Sulawesi Tengah yang unik dan baru ditemukan yang berasal dari Tentena, Sulawesi Tengah. Tanaman dengan genus Etlingera merupakan salah satu dari sekian banyak tanaman yang memiliki potensi sebagai antioksidan alami. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol E. comosa terhadap penurunan kadar glukosa darah dan gambaran histopatologi pankreas tikus putih jantan. Penelitian ini dilakukan dengan menggunakan acak lengkap pola searah. Metode yang dilakukan dalam penelitian ini adalah dengan menggunakan tikus putih Jantan (Rattus norvergicus) sebanyak 30 ekor yang dibagi menjadi 6 kelompok (masing-masing 5 ekor tikus) yaitu kontrol normal, kontrol positif, kontrol negatif, ekstrak 100 mg/kgBB dan ekstrak 200 mg/KgBB dan ekstrak 400 mg/kgBB. Semua kelompok diberi streptozotocin kecuali kontrol normal. Pengukuran kadar glukosa menggunakan alat glukometer dan kerusakan histopatologi pankreas diamati dengan metode pewarnaan HE. Hasil penelitian terhadap kadar glukosa darah menunjukkan adanya perbedaan signifikan setiap minggunya, begitu pun dengan hasil skoring kerusakan pankreas. Pemberian ekstrak dosis 400 mg/kgBB menunjukkan efek yang tidak berbeda signifikan dibandingkan kontrol positif (p>0,05) namun berbeda signifikan dibandingkan kontrol negatif (p<0,05) pada penurunan kadar glukosa darah dan skor kerusakan pankreas sehingga dapat disimpulkan pemberian ekstrak etanol E. comosa memberikan pengaruh terhadap kadar glukosa darah dan skor kerusakan pankreas dengan dosis yang efektif adalah dosis 400 mg/kgBB
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