Analysis of Potential Interactions BetweenAnalysis of potential interactions between drugs in polypharmacy prescriptions in Bandung City pharmacies
Main Article Content
Page: 94-99
Abstract
Problems that can occur in drug prescribing patterns are Drug Related Problems (DRP), which can affect the patient's clinical condition. One type of DRP that often occurs is drug interactions. Drug interactions cause changes in the effect of a drug due to the presence of other drugs taken simultaneously, which will cause a decrease in the therapeutic effect of the drug and increase toxicity in the body. Therefore, drug interactions were identified from general practitioner prescriptions at one of the Bandung City pharmacies. General practitioner prescription data was taken from July-September 2023 at the pharmacy in Bandung City, namely 202 prescriptions, and categorized based on their severity using the website drug, com. The results of this identification showed that 32 prescriptions had interactions between drugs with different levels of severity, showing that 2 prescriptions (6%) had drug interactions of different types. In the majority, 24 prescriptions (75%) had moderate drug-type interactions, and 6 recipes (19%) had minor.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
References
Agustin OA, Fitrianingsih F. Kajian Interaksi Obat Berdasarkan Kategori Signifikansi Klinis Terhadap Pola Peresepan Pasien Rawat Jalan Di Apotek X Jambi. Electron J Sci Environ Heal Dis 2021;1:1–10. https://doi.org/10.22437/esehad.v1i1.10759. DOI: https://doi.org/10.22437/esehad.v1i1.10759
Womsiwor I, Tampa’i R, Kanter JW, Potalnagi NO. Analisis Drug Related Problems (DRPS) pada Pasien Hipertensi Geriatri di Puskesmas Rurukan Tomohon. Trop J Biopharm 2023;6:25–31.
Saputri, Gusti Ayu Rai; Angin MP, Setia NE. Evaluasi Interaksi Obat Pada Pasien Diabetes Melitus Tipe 2 Rawat Jalan Di Rumah Sakit Umum Daerah Provinsi NTB Tahun 2021. J Farm Malahayati 2022;5:250–7. DOI: https://doi.org/10.33024/jfm.v5i2.5988
Perdana Putra AM, Wasiaturrahmah Y, Rahmah N, Nahdha. Potensi Interaksi Obat pada Pasien COVID-19 di Salah Satu Rumah Sakit di Provinsi Kalimantan Selatan. Maj Farm Dan Farmakol 2021;25:94–7. https://doi.org/10.20956/mff.v25i3.18238. DOI: https://doi.org/10.36387/jifi.v5i1.917
Reyaan IBM, Kuning C, Adnyana IK. Studi Potensi Interaksi Obat pada Resep Polifarmasi di Dua Apotek Kota Bandung. J Manaj DAN PELAYANAN Farm (Journal Manag Pharm Pract 2021;11:145. https://doi.org/10.22146/jmpf.56931. DOI: https://doi.org/10.22146/jmpf.56931
Solang NG, Wiyono W, Mpila DA. Identifikasi Interaksi Obat Potensial Pada Pasien Stroke Rawat Inap Di Rsup Prof. Dr. R. D. Kandou Manado. Pharmacon 2021;10:639. https://doi.org/10.35799/pha.10.2021.32749. DOI: https://doi.org/10.35799/pha.10.2021.32749
Ulfa F, Pradana ES, Lestari K. Identifikasi Potensi Interaksi Antar Obat Pada Resep Spesialis Penyakit Dalam Di Salah Satu Apotek Di Kota Bandung. J Farmaka 2021;19:7–14.
Zhuang X, Li L, Liu T, Zhang R, Yang P, Wang X, et al. Mechanisms of isoniazid and rifampicin-induced liver injury and the effects of natural medicinal ingredients: A review. Front Pharmacol 2022;13:1–18. https://doi.org/10.3389/fphar.2022.1037814. DOI: https://doi.org/10.3389/fphar.2022.1037814
Rahayu FP, Susilawati Y. Identifikasi Interaksi Obat Pada Resep Tentang Gangguan Pernapasan Di Bulan Februari 2023 Di Apotek Kota Bandung. Farmaka 2023;21:298–306.
Rad AK, Mehrjerdi HK, Pedram MS, Azizzadeh M, Amanollahi S. Clinical Evaluation of the Effect of Methylprednisolone Sodium Succinate and Meloxicam in Experimental Acute Spinal Cord Injury. Iran J Vet Med 2023;17:129–38. https://doi.org/10.32598/ijvm.17.2.1005246. DOI: https://doi.org/10.32598/IJVM.17.2.1005246
Nopitasari LB. Studi Penggunaan Obat Pada Pasien Osteoarthritis Usia Lanjut Di Instalasi Rawat Jalan Rumah Sakit Umum Daerah Provinsi NTB Periode 2019. J Ilmu Kefarmasian 2022;3:246–53.
Yuan L, Cai K, Zou Y. Clinical Efficacy of Huangkui Capsule Plus Methylprednisolone for Immunoglobulin A Nephropathy and Its Effect on Renal Function and Serum Inflammatory Factors. Evidence-Based Complement Altern Med 2023;2023. https://doi.org/10.1155/2023/3020033. DOI: https://doi.org/10.1155/2023/9767505
Srikandi Ardiansyah EEP, Herda Ariyani, Hendera. Studi literatur efek penggunaan non-steroidal anti inflammatory drugs (NSAID) pada sistem gastrointestinal (Literature Study Of The Non-Steroidal Anti Inflammatory Drugs (NSAIDs) On The Gastrointestinal System). J Curr Pharm Sci 2021;5:418–28.
Nata AS, Kurniawati D, Herawati A. Studi Rasionalitas Penggunaan Obat Rheumatoid Arthritis Pada Pasien Rawat Jalan Di Rumah Sakit Umum Daerah Ulin 2023;1:59–67. DOI: https://doi.org/10.57235/motekar.v1i2.1169
Nisa SK. Identifikasi potensi interaksi antar obat pada resep umum di Apotek x bulan januari 2020. J Farmaka 2020;18:1–15.
Oboh G, Ogunbadejo MD, Ogunsuyi OB, Oyeleye SI. Can gallic acid potentiate the antihyperglycemic effect of acarbose and metformin? Evidence from streptozotocin-induced diabetic rat model. Arch Physiol Biochem 2022;128:619–27. https://doi.org/10.1080/13813455.2020.1716014. DOI: https://doi.org/10.1080/13813455.2020.1716014