Therapeutic Potential of Purslane (Portulaca oleracea L.) Extract in Diabetes Type-2 Management: A Literature Review
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Abstract
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterised by insulin resistance, aberrant insulin secretion, and persistent hyperglycemia. There are different treatments existing but there is a need for complementary. Portulaca oleracea L. (purslane) medicinal herb with bioactive substance having antidiabetic property. The purpose of this study was to aimed Portulaca oleracea L. therapeutic potential, bioactive components, and underlying processes in the treatment of type 2 diabetes. The literature review was developed through a comprehensive examination of published journal articles retrieved from major academic databases, including Google Scholar, NCBI, PubMed, and ScienceDirec. Many studies have demonstrated that Portulaca oleracea L. possesses significant antidiabetic effect. These seem to result from insulin-sensitizing,a generalized, suppression of NF-κB-related inflammation, AMPK pathway stimulation/activation of eNOS expression in general, gut bacteria regulation effects, and carbohydrate digesting inhibition; whether by glycemic index level processes use/alleviation of those responses as an energy expenditure process. The dose effective in animal studies is between 50 and 500 mg/kg/day. Immediate clinical trials (1.0–1.8 g/day) demonstrate powerful improvements of fasting glucose, HbA1c lipid metabolism, and oxidative stress marker. Portulaca oleracea L. showed promise as an additional treatment for type 2 diabetes. Its bioactive components work in concert to address a variety of pathogenic targets. To validate the best therapeutic use, standardized extraction procedures and extensive clinical dose-finding studies are required.
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References
Ruze R, Liu T, Zou X, Song J, Chen Y, Xu R, et al. Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments. Front Endocrinol (Lausanne) 2023;14:1161521. DOI: https://doi.org/10.3389/fendo.2023.1161521
Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB, et al. Pathophysiology of type 2 diabetes mellitus. Int J Mol Sci 2020;21:6275. DOI: https://doi.org/10.3390/ijms21176275
Galicia-Garcia U, Jebari S, Larrea-Sebal A, Uribe KB, Siddiqi H, Ostolaza H, et al. Statin treatment-induced development of type 2 diabetes: from clinical evidence to mechanistic insights. Int J Mol Sci 2020;21:4725. DOI: https://doi.org/10.3390/ijms21134725
Forni C, Facchiano F, Bartoli M, Pieretti S, Facchiano A, D’Arcangelo D, et al. Beneficial role of phytochemicals on oxidative stress and age‐related diseases. Biomed Res Int 2019;2019:8748253. DOI: https://doi.org/10.1155/2019/8748253
Chahrour JA, Abdel Baki Z, El Badan D, Nasser G, Maresca M, Hijazi A. Herbal Medicines in the Management of Diabetes Mellitus: Plants, Bioactive Compounds, and Mechanisms of Action. Biomolecules 2025;15:1674. DOI: https://doi.org/10.3390/biom15121674
Mahmoud AD, Al-Rawi SS, Hama HA. Traditional uses, bioactive compounds and pharmacological uses of Vitex doniana Sweet: a review. Ethnobot Res Appl 2025;30:1–130. DOI: https://doi.org/10.32859/era.30.12.1-130
Latif R, Nawaz T. Medicinal plants and human health: A comprehensive review of bioactive compounds, therapeutic effects, and applications. Phytochem Rev 2025:1–44. DOI: https://doi.org/10.1007/s11101-025-10194-7
Alam S, Sarker MMR, Sultana TN, Chowdhury MNR, Rashid MA, Chaity NI, et al. Antidiabetic phytochemicals from medicinal plants: prospective candidates for new drug discovery and development. Front Endocrinol (Lausanne) 2022;13:800714. DOI: https://doi.org/10.3389/fendo.2022.800714
Gu Y, Ying Z, Lan X, Ying X, Yang G. Two new esters from the aerial parts of Portulaca oleracea L. and their bioactivities. Phytochem Lett 2021;44:98–101. DOI: https://doi.org/10.1016/j.phytol.2021.06.009
Guo J, Peng J, Han J, Wang K, Si R, Shan H, et al. Extracts of Portulaca oleracea promote wound healing by enhancing angiology regeneration and inhibiting iron accumulation in mice. Chinese Herb Med 2022;14:263–72. DOI: https://doi.org/10.1016/j.chmed.2021.09.014
Bai Y, Zang X, Ma J, Xu G. Anti-diabetic effect of Portulaca oleracea L. Polysaccharideandits mechanism in diabetic rats. Int J Mol Sci 2016;17:1201. DOI: https://doi.org/10.3390/ijms17081201
Zheng G, Mo F, Ling C, Peng H, Gu W, Li M, et al. Portulaca oleracea L. alleviates liver injury in streptozotocin-induced diabetic mice. Drug Des Devel Ther 2017:47–55. DOI: https://doi.org/10.2147/DDDT.S121084
Bao M, Hou K, Xin C, Zeng D, Cheng C, Zhao H, et al. Portulaca oleracea L. extract alleviated type 2 diabetes via modulating the gut microbiota and serum branched‐chain amino acid metabolism. Mol Nutr Food Res 2022;66:2101030. DOI: https://doi.org/10.1002/mnfr.202101030
El-Sayed M-IK. Effects of Portulaca oleracea L. seeds in treatment of type-2 diabetes mellitus patients as adjunctive and alternative therapy. J Ethnopharmacol 2011;137:643–51. DOI: https://doi.org/10.1016/j.jep.2011.06.020
Miao L, Zhou C, Zhang H, Cheong MS, Tan Y, Wang Y, et al. Portulaca oleracea L.(purslane) extract protects endothelial function by reducing endoplasmic reticulum stress and oxidative stress through AMPK activation in diabetic obese mice. Antioxidants 2023;12:2132. DOI: https://doi.org/10.3390/antiox12122132
Roozi H, Akbar Boojar MM, Eidi A, Khavari-Nejad R. The effect of portulaca oleracea alkaloids on antidiabetic properties through changes in ceramide metabolism. Egypt J Basic Appl Sci 2021;8:156–66. DOI: https://doi.org/10.1080/2314808X.2021.1877889
Daneva Y, Zheleva-Dimitrova D, Simeonova R. Comparative study on the effects of Portulaca oleracea extract and a commercial dietary supplement in spontaneously hypertensive rats with induced type 2 diabetes. Pharmacia 2026;73:1–10. DOI: https://doi.org/10.3897/pharmacia.73.e191604
Ahangarpour A, Oroojan AA, Khorsandi L, Lamoochi Z. Effect of hydroalcoholic extract of purslane (Portulaca oleracea L.) on diabetic variables in D-galactose induced aging mouse model. Acta Endocrinol 2018;14:24. DOI: https://doi.org/10.4183/aeb.2018.24
Oyabambi AO, Aindero BB, Awolola AM, Adebayo AY, Iluromi IB, Olorunniyi KS. Portulaca oleracea (purslane) aqueous extract reduced the adverse metabolic outcomes and favored liraglutide activities in streptozotocin-induced cardiometabolic disorders of male Wistar rats. Endocr Metab Sci 2024;16:100191. DOI: https://doi.org/10.1016/j.endmts.2024.100191
Mohammed MT. Positive influence of Portulaca Oleracea L. in rats with type 2 diabetes mellitus 2020.
Budaya AT, Kaharuddin PR, Said AA, Jannah SN, Nicola N, Bahrun B, et al. Enhancing antidiabetic bioactivity of purslane leaf extract (Portulaca oleracea L.) through synthesis of nanoemulsion: In vitro and in vivo evidence. J Res Pharm 2025;29:1007–16. DOI: https://doi.org/10.12991/jrespharm.1694160
Wainstein J, Landau Z, Dayan YB, Jakubowicz D, Grothe T, Perrinjaquet-Moccetti T, et al. Purslane extract and glucose homeostasis in adults with type 2 diabetes: A double-blind, placebo-controlled clinical trial of efficacy and safety. J Med Food 2016;19:133–40. DOI: https://doi.org/10.1089/jmf.2015.0090