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Zana Sahya Locita
Nurul Mutmainah

Page: 2963-2975

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Latar belakang: Stroke Non hemoragik atau stroke iskemik merupakan bentuk stroke yang paling umum merupakan salah satu penyebab utama mortalitas dan kecacatan. Pengendalian tekanan darah melalui penggunaan antihipertensi menjadi bagian penting dari pencegahan sekunder, namun variasi praktik klinis menunjukkan bahwa rasionalitas penggunaan obat masih perlu dievaluasi. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara rasionalitas obat antihipertensi dengan kontrol tekanan darah pada pasien stroke non hemoragik berdasarkan parameter klinis yaitu tekanan darah di instalasi rawat inap Rumah Sakit X Surakarta. Metode: Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross-sectional secara retrospektif. Data mengenai penggunaan obat diperoleh dari rekam medis tahun 2024 di Instalasi Rawat Inap Rumah Sakit X Surakarta, dengan total 100 pasien yang memenuhi kriteria inklusi. Analisis data dilakukan dengan menggunakan uji statistik Chi-square. Hasil: Penggunaan antihipertensi pada pasien stroke non hemoragik di Instalasi Rawat Inap RS X Surakarta tahun 2024 sebanyak 90 pasien sudah mendapatkan terapi yang rasional. Terapi antihipertensi didominasi oleh golongan CCB dihidropiridin terutama amlodipine baik monoterapi maupun kombinasi. Hasil analisis Fisher’s exact test menunjukkan nilai p < 0.05 yang mengindikasikan adanya hubungan signifikan antara rasionalitas penggunaan antihipertensi dengan kontrol tekanan darah. Kesimpulan: Terdapat hubungan kerasionalan obat antihipertensi dengan kontrol tekanan darah pada pasien stroke non hemoragik, sehingga rasionalitas pemilihan obat antihipertensi menjadi aspek krusial dalam upaya pencegahan sekunder pada pasien stroke non hemoragik.

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Locita , Z. S., & Mutmainah, N. (2025). Hubungan Kerasionalan Obat Antihipertensi Dengan Kontrol Tekanan Darah Pada Pasien Stroke Non-Hemoragik di Instalasi Rawat Inap RS X Surakarta Tahun 2024. Journal of Pharmaceutical and Sciences, 8(4), 2963–2975. https://doi.org/10.36490/journal-jps.com.v8i4.1261
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Original Articles

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