Effect of giving ekor naga leaf extract gel (Rhaphidophora pinnata) on differential rat leukocytes induced by carrageenan air pouch
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Abstract
Ekor naga leaves gel preparations have been pharmacologically proven to have an anti-inflammatory effect by reducing inflammation in the skin of mice. Leukocyte differential describes the repair of leukocyte cells in overcoming inflammation. The research aimed to determine the effect of administering ekor naga leaves extract gel on the differential number of leukocytes in mice induced by air pouch carrageenan. The research method used is experimental design. The treatment group consisted of 5 groups, with five mice in each group. Positive control group (Hydrocortisone®), Formula 0 (Gel Base), Formula 1 (Extract concentration 10%), Formula 2 (Extract concentration 15%), Formula 3 (Extract concentration 20%). The research data obtained was analyzed using one-way ANOVA with a confidence level of 95%. Research results show that Formula 2 is the best.
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References
Alderton, G., & Scanlon, S. T. (2021). Inflammation. Science (New York, N.Y.), Vol. 374. https://doi.org/10.1126/science.abn1721
Anatasya, B., Sanik, F., & Muhaimin, M. (2021). Topical anti-inflammatory effect of Ekor Naga (Rhaphidophora pinnata (L.f) Schott) leaves extract. Pharmaciana, 11(3), 303. https://doi.org/10.12928/pharmaciana.v11i3.17617
Antunes-Ricardo, M., Gutierrez-Uribe, J., & Serna-Saldivar, S. (2015). Anti-inflammatory Glycosylated Flavonoids as Therapeutic Agents for Treatment of Diabetes-Impaired Wounds. Current Topics in Medicinal Chemistry. https://doi.org/10.2174/1568026615666150619141702
Astika, R. Y., Sani, F., & Elisma. (2022). Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Kayu Manis (Cinnamomum burmanni) Pada Mencit Putih Jantan. Jurnal Ilmiah Manuntung, 8(1), 14–23.
Bokti, S. B. K., & Saputri, F. A. (2018). Formulasi dan evaluasi sediaan gel dari ekstrak seledri Apium graveolens. Linn. Sebagai Anti-Inflamasi. Farmaka, 16(1).
Citra Ayudystira Ramadhani, Asmilia, N., & Fahrimal, Y. (2023). Pengaruh Pemberian Ekstrak Etanol Daun Malaka (Phyllantus emblica) Terhadap Jumlah dan Diferensial Leukosit Tikus Putih (Rattus norvegicus) yang Diinfeksi Trypanosoma evansi. Acta Veterinaria Indonesiana, 11(2). https://doi.org/10.29244/avi.11.2.95-101
de Oliveira, M. L. M., Nunes-Pinheiro, D. C. S., Tomé, A. R., Mota, É. F., Lima-Verde, I. A., Pinheiro, F. G. de M., … de Morais, S. M. (2010). In vivo topical anti-inflammatory and wound healing activities of the fixed oil of Caryocar coriaceum Wittm. seeds. Journal of Ethnopharmacology, 129(2). https://doi.org/10.1016/j.jep.2010.03.014
Dillasamola, D., Dharma, S., Aldi, Y., Berd, I., Hadyan, A., & Biomechy Oktomalio, P. (2016). Anti-inflammatory effects test of ethanol extract of mistletoe leaves coffee Scurrula ferruginea (jack) danser with methods granuloma pouch. Der Pharma Chemica.
Fehrenbacher, J. C., & McCarson, K. E. (2021). Models of Inflammation: Carrageenan Air Pouch. Current Protocols, 1(8). https://doi.org/10.1002/cpz1.183
Hettwer, J., Hinterdobler, J., Miritsch, B., Deutsch, M. A., Li, X., Mauersberger, C., … Sager, H. B. (2022). Interleukin-1ß suppression dampens inflammatory leucocyte production and uptake in atherosclerosis. Cardiovascular Research, 118(13). https://doi.org/10.1093/cvr/cvab337
K, F. S., Rahman, H., Rahman, A. O., Samudra, A. G., & Floris, C. De. (2022). Incision wound healing test ethanolic extract gel from Ekor Naga ( Rhaphidophora pinnata ( L . f ) Schott ) leaves in white male rats. 12(2). https://doi.org/10.12928/pharmaciana.v12i2.22825
Kratofil, R. M., Kubes, P., & Deniset, J. F. (2017). Monocyte conversion during inflammation and injury. Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 37. https://doi.org/10.1161/ATVBAHA.116.308198
Lubis, I. S. K. (2016). Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Pegagan (Centellaasiatica L.) DAN Pengaruhnya Terhadap Jumlah Leukosit Pada Tikus Jantan Yang Diinduksi Karagenan.Skripsi. Universitas Sumatera Utara.
Suryandari, S. S., Queljoe, E. De, & Datu, O. S. (2021). Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Sesewanua (Clerodendrum squamatum Vahl.) Terhdapat Tikus Putih (Rattus norvegicus L.)byang Diinduksi Karagenan. Pharmacon, 10, 1025–1032.
Zamil, S. T., Zamil, S. T., Naser, N. A., & Kadhim, H. A. (2022). Formulation and Evaluation of Topical Formula Gel for Dermatitis and Inflammations. International Journal of Drug Delivery Technology, 12(2). https://doi.org/10.25258/ijddt.12.2.62.