The Integrating Precision Genomic Strategies and Islamic Ethical Perspectives in Stunting Prevention: Focus on the Growth Hormone-IGF-1 Pathway

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Published: May 3, 2026
DOI: https://doi.org/10.36490/journal-jps.com.v9i2.1320
Keywords:
Stunting, Genetics, GH-IGF1, Maqāṣid al-Sharī‘ah, Hifz al-Nasl

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Hifdzil Qur’ani
Universitas Singaperbangsa Karawang
Nasywa Khoirun Nisa
Universitas Singaperbangsa Karawang
Pramudya Pratama
Universitas Singaperbangsa Karawang
Ahsanal Kasasiah
Universitas Singaperbangsa Karawang
Jekmal Malau
Universitas Indonesia

Page: 1132-1144

Abstract

Stunting remains one of the major chronic nutritional problems in Indonesia. The national prevalence of stunting has decreased from 37.2% in 2013 to 19.8% in 2024; however, this figure is still above the World Health Organization threshold (<20%) and has not yet reached the national target of 14%. The interaction of nutritional, environmental, and genetic factors influences stunting. Genetic variations within the Growth Hormone–Insulin-like Growth Factor One pathway play a significant role in regulating linear growth in children; disruptions in this pathway can increase vulnerability to stunting. In addition, the majority of Indonesia's population adheres to Islam, making religious values a strategic potential for strengthening health interventions. This review article examines the integration of scientific approaches, focusing on genetics and Islamic values, in stunting prevention by highlighting polymorphisms in the IGF1, IGF1R, and GHR genes and their relevance to the principles of maqāsid al-sharī‘ah, particularly hifz al-nasl (protection of lineage). The analysis is conducted using a descriptive-analytical approach based on recent scientific literature and Islamic references, including the Qur’an, prophetic traditions, and scholarly exegesis. The findings indicate a strong alignment between scientific approaches and Islamic teachings, including the importance of adequate nutrition during pregnancy, exclusive breastfeeding, consumption of lawful, nutritious food, genetic screening efforts consistent with the values of divine decree, and vitamin D supplementation to support Insulin-like Growth Factor One levels. This integration has the potential to enhance community acceptance of stunting-prevention programs, strengthen moral and spiritual motivation, and support the achievement of national stunting-reduction targets. Thus, an approach that combines precise genomics and Islamic values may serve as a contextual and sustainable strategy in shaping a generation that is healthy, intelligent, and spiritually resilient.

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How to Cite
Qur’ani , H., Nisa, N. K., Pratama, P., Kasasiah , A., & Malau, J. (2026). The Integrating Precision Genomic Strategies and Islamic Ethical Perspectives in Stunting Prevention: Focus on the Growth Hormone-IGF-1 Pathway. Journal of Pharmaceutical and Sciences, 9(2), 1132–1144. https://doi.org/10.36490/journal-jps.com.v9i2.1320
Issue
JPS Volume 9 Nomor 2 (2026)
Section
Review Article
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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Author Biographies

Hifdzil Qur’ani , Universitas Singaperbangsa Karawang

 Hifdzil Qurani,  is an undergraduate Pharmacy student  at Universitas Singaperbangsa Karawang, Indonesia. He conducts research on personalized medicine, including the GH–IGF1 pathway and its relation to stunting. Hifdzil has experience in patient counseling, clinical skills competitions, and event organization, demonstrating expertise in pharmaceutical biotechnology, pharmacogenomics, and integrative research combining genetics, nutrition, and Islamic values for public health interventions.

Nasywa Khoirun Nisa , Universitas Singaperbangsa Karawang

Nasywa Khoirun Nisa, is an undergraduate Pharmacy student at Universitas Singaperbangsa Karawang, Indonesia. She actively develops her skills through organizational involvement, particularly as a member of the Pharmacy Student Association (Himfar) and the Student Legislative Body (BLM), which strengthens her leadership, advocacy, and student activity management abilities. In the academic field, Nasywa has an interest in research focusing on modern pharmaceutical approaches, including pharmacogenomics and its relevance to personalized therapy. She is particularly interested in integrating genetics, nutrition, and Islamic values to enhance holistic and ethical public health interventions. Additionally, Nasywa has experience in essay and scientific writing competitions, which have helped refine her analytical and scientific reasoning skills.

Pramudya Pratama , Universitas Singaperbangsa Karawang

Pramudya Pratama, is an undergraduate Pharmacy student at Universitas Singaperbangsa Karawang, Indonesia. He actively develops his skills through various organizational activities and committees, which strengthen his leadership, teamwork, and student activity management abilities. In the academic field, Pramudya is interested in research focusing on modern pharmacy and natural products, including the development of preparations based on natural extracts and their therapeutic applications. He is particularly interested in integrating nutrition and Islamic values to enhance holistic and ethical public health interventions. Additionally, Pramudya has experience in essay and scientific writing competitions, which have helped refine his analytical and scientific reasoning skills.

Ahsanal Kasasiah , Universitas Singaperbangsa Karawang

Ahsanal Kasasiah,  is a lecturer in the Department of Pharmacy, Faculty of Health Sciences, Universitas Singaperbangsa Karawang, Indonesia. She holds a Master’s degree in Biotechnology from Institut Teknologi Bandung. Her academic expertise is centered on molecular biotechnology and applied pharmaceutical sciences, particularly gene polymorphism studies, PCR-based molecular techniques, and microbiological analysis related to health and safety. Her scholarly work also addresses antibacterial studies, quality and safety assessment of food and herbal products.

Jekmal Malau, Universitas Indonesia

Jekmal Malau,  serves as a lecturer and researcher in the Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang. He is currently undertaking doctoral studies in Biomedical Sciences at the Faculty of Medicine, Universitas Indonesia. Prior to his academic tenure, he gained nearly six years of experience in the biomedical sector, holding roles as a Field Application Scientist and later as a Supervisor in molecular diagnostics and life science technologies. His academic interests encompass pharmaceutical biotechnology, molecular biology, and pharmacogenomics. He has written and edited around 30 scientific books and frequently engages in national and international professional training to support biomedical advancement and education.

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