Interaksi Padatan dan Pembentukan Eutektik dalam Campuran Biner Gemfibrozil-Nikotinamida
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Latar Belakang: Gemfibrozil merupakan obat antihiperlipidemia yang efektif menurunkan kadar kolesterol dan trigliserida dalam darah. Namun, gemfibrozil mempunyai kendala yaitu sifat kelarutan dan mekanik yang rendah. Tujuan: Tujuan penelitian ini adalah menganalisis interaksi padatan pada campuran biner gemfibrozil-nikotinamida yang sangat diperlukan pada penerapan sistem padatan multikomponen untuk peningkatan sifat fisikokimia dari gemfibrozil. Metode: Metode yang digunakan untuk analisis interaksi padatan adalah differential scanning calorimetry (DSC) melalui penyusunan diagram fase padat-cair dan dilanjutkan dengan analisis Fourier transform infrared spectroscopy (FTIR) untuk mengidentifikasi interaksi ikatan hidrogen antar komponen. Hasil: Hasil penelitian menunjukkan bahwa gemfibrozil dengan nikotinamida membentuk diagram fase padat-cair dengan kurva padat tipe-V. Campuran biner gemfibrozil – nikotinamida membentuk campuran eutektik pada perbandingan molar 8:2 dengan titik lebur eutektik pada 59,3 oC. Pengujian dengan FTIR mengindikasikan tidak ada interaksi ikatan hidrogen antara gemfibrozil dengan nikotinamida. Kesimpulan: Gemfibrozil dalam sistem campuran biner tidak membentuk interaksi padatan dengan nikotinamida namun merupakan campuran eutektik. Hal ini dapat digunakan untuk merancang strategi pada peningkatan sifat fisikokimia gemfibrozil melalui pembentukan padatan multikomponen.
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Referensi
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