Formulasi Granul Effervescent Mengandung Ekstrak Daun Cyclea barbata Miers: Evaluasi Fisik (Sebelum dan Sesudah Rekonstitusi)
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Ekstrak daun Cyclea barbata Miers mengandung senyawa flavonoid yang mempunyai aktivitas antiinflamasi. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi asam sitrat dan natrium bikarbonat terhadap sifat fisik granul effervescent sebelum (uji organoleptik, waktu alir, sudut diam, kadar air, dan indeks kompresibilitas) dan setelah (uji organoleptik, waktu larut, tinggi busa, pH, dan hedonik) rekonstitusi. Granul effervescent diformulasikan menggunakan metode granulasi basah dengan variasi konsentrasi asam sitrat: natrium bikarbonat berturut-turut yaitu FI (17%:30%), FII (20%:27%) dan FIII (23%:24%). Berdasarkan hasil uji evaluasi sifat fisik granul effervescent, FI dan FII sesuai dengan persyaratan masing-masing pengujian, sedangkan FIII tidak sesuai dengan persyaratan pada uji waktu alir, sudut diam, tinggi busa dan pH. Studi ini menyimpulkan bahwa FI adalah formula terbaik (17%: 30%).
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