Formulation of Ibuprofen Tablet with Excipients Rice Starch (Oryza sativa L.) Pregelatinization and Polyvinyl Pyrrolidone Using Simplex Lattice Design Method
Article Sidebar
Main Article Content
Page: 1167-1176
Abstract
Rice starch is a natural material that can be used as a tablet disintegrant to reduce reliance on synthetic pharmaceutical excipients, but it has poor flowability and low bulk density. Pregelatinization is one way to improve the physical properties of starch as a tablet disintegrant. This study aims to optimize the ibuprofen tablet formula using a combination of pregelatinized rice starch as a disintegrant and polyvinyl pyrrolidone as a binder. Both materials are optimized using the Design Expert V13 program using the Simplex Lattice Design method. The parameters of the granules evaluated include flow rate, angle of repose, and compressibility index. For tablets, physical properties are tested including hardness, brittleness, and disintegration time, as well as weight diversity for the optimal formula. Furthermore, verification is carried out for the optimal formula and weight diversity tests are added. The optimal ibuprofen tablet formula obtained is for 5.5% pregelatinized rice starch and 5% PVP with a desirability value of 0.909 shows the optimal design because the desirability value range is in the range 0-1. Confirmation of the optimal formula based on its physical properties includes a flow rate test of 11.96 g/s ± 0.06, an angle of repose of 32.06º ± 0.75, a compressibility index of 14.84% ± 2.65, a tablet hardness of 7.29 kg ± 0.28, a tablet friability of 0.63% ± 0.19, a tablet disintegration time of 11.02 minutes ± 0.07, and a weight diversity of 96.96% and NP of 8.324. The results of physical tests show that the optimal formula meets the requirements for good physical properties of tablets
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
References
Najihudin A, Anshar Nuari D, Frisma Sriarumtias F, Roila Julaikho Y. Formulation And Evaluation Of Tablets Of Active Antioxidant Fraction Green Grass Jelly Leaves (Premna Oblongata Miq.). J Ilm Farm Bahari 2021:88–98. DOI: https://doi.org/10.52434/jfb.v12i1.1096
ambari Y, Nurrosyidah IH, Kusumo ST. Optimasi Formulasi Tablet Ibuprofen Dengan Kombinasi CMC–NA & Sorbitol Sebagai Pengikat dan Amilum Solani Sebagai Disintegran Terhadap Waktu Hancur Tablet. J Pharm Care Anwar Med 2019;2:8–17. https://doi.org/10.36932/jpcam.v2i1.14. DOI: https://doi.org/10.36932/jpcam.v2i1.14
Yulyadah D, Yuniarsih N, Fikayuniar L. Uji Evaluasi Tablet Ibuprofen Dengan Menggunakan Pengikat Dari Amilum Umbi Garut (Marantha Arundinaceae L.). J Buana Farma 2021;1:24–30. https://doi.org/10.36805/jbf.v1i3.162. DOI: https://doi.org/10.36805/jbf.v1i3.162
Dwi Rahayuningsih, Agus Siswanto S. Pengaruh Penggunan Amilum Singkong Pregelatinasi Sebagai Bahan Penghancur Terhadap Sifat Fisik Tablet Aspirin 2010;07:28–38.
Devi I ayu S. Optimasi Konsentrasi Polivinil Pirolidon (PVP) sebagai Bahan Pengikat tehadap Sifat Fisik Tablet Ekstrak Etanol Rimpang Bangle (Zingiber cassumunar Roxb). J Farm Udayana 2018;7:45. https://doi.org/10.24843/jfu.2018.v07.i02.p02. DOI: https://doi.org/10.24843/JFU.2018.v07.i02.p02
Rijal M, Buang A, Prayitno S. Pengaruh Konsentrasi Pvp K - 30 Sebagai Bahan Pengikat Terhadap Mutu Fisik Tablet Ekstrak Daun Tekelan (Chromolaena Odorata. (L.). J Kesehat Yamasi Makasar 2022;6:98–111.
Afriliana HS, W YN. Pengaruh Penggunaan Amilum Biji Durian (Durio zibethinus l.) Sebagai Bahan Penghancur Yang Ditambahkan Secara Internal-Eksternal Terhadap Sifat Fisik dan Kimia Tablet Ibuprofen 2013:31–5.
Hartesi B, Meirista I, Mariska RP, Soyata A, Fitria F, Lestari O. Modifikasi Pati Beras Ketan Putih Sebagai Pengisi Pada Pembuatan Tablet Kempa Langsung. Maj Farmasetika 2022;8:70. https://doi.org/10.24198/mfarmasetika.v8i1.42081. DOI: https://doi.org/10.24198/mfarmasetika.v8i1.42081
Syaputri FN, Saila SZ, Tugon TDA, R. AP, Lestari D. Formulasi dan Uji Karakteristik Fisik Sediaan Granul Effervescent Ekstrak Etanol Daun Sirih Merah (Piper crocatum ruiz) Sebagai Antidiabetes. J Ilmu Kefarmasian 2023;4:191–8. DOI: https://doi.org/10.36456/farmasis.v4i1.6915
Rowe RC, Sheskey PJ dan QM. Vdoc.Pub_Handbook-of-Pharmaceutical-Excipients-8Th.Pdf 2017.
USP. The United States Pharmacopeial Convention (USP-NF) 2024:2.
Putra Pratama N, Rahayu Purnomo Sari K, Kurniawati E. Jurnal Farmasi Sains dan Praktis FORMULATION OF CHEWABLE TABLET PREPARATIONS FROM THE COMBINATION OF Azadirachta Indica A. Juss. AND Gynura Procumbens (Merr.). Jfsp 2022;8:2579–4558. DOI: https://doi.org/10.31603/pharmacy.v8i1.5918
Depkes RI. Farmakope Indonesia edisi VI. 2020.
Pratama R, Pahlevi MR, Santoso R, Rafli TM. Formulasi dan Evaluasi Granul Instan Ekstrak Etanol Daun Kenikir (Cosmos caudatus) sebagai Antioksidan. Maj Farmasetika 2024;9:276. https://doi.org/10.24198/mfarmasetika.v9i3.53782. DOI: https://doi.org/10.24198/mfarmasetika.v9i3.53782
Devianti VA, Yulianti CH. Pengaruh Amilum Beras Ketan (Oryza Sativa Lf glutinosa Auct) Sebagai Bahan Penghancur Terhadap Sifat Fisis Tablet Vitamin B6. J Pharm Sci 2021;3:9–12.
Putra RM, Fahrurroji A, Wijianto B. Optimasi Formulasi Sabun Mandi Cair Ekstrak Etanol Rimpang Jahe Merah (Zingiber officinale Rosc. var rubrum) Dengan Metode Simplex Lattice Design. J Teknosains 2017;5:111. https://doi.org/10.22146/teknosains.5341. DOI: https://doi.org/10.22146/teknosains.5341