Efek Terapi Adjuvan Gel Kolagen terhadap Kadar Matriks Metaloproteinase-8 Saliva pada Gingivitis Pasca Scaling Root Planing
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Gingivitis merupakan kondisi inflamasi reversibel pada jaringan gingiva tanpa kehilangan perlekatan yang terutama disebabkan oleh akumulasi plak sehingga dapat memicu respon imun. Matriks metaloproteinase-8 merupakan salah satu enzim yang berkontribusi dalam memecah kolagen. Scaling and root planing merupakan terapi standar, namun dapat menimbulkan respons inflamasi sementara dan regenerasi jaringan yang kurang optimal, sehingga diperlukan terapi adjuvan. Penelitian ini bertujuan untuk mengevaluasi efek terapi adjuvan gel kolagen terhadap kadar matriks metaloproteinase-8 saliva pada gingivitis. Penelitian ini merupakan studi eksperimental dengan rancangan pre- dan post-test control group desain yang melibatkan 50 subjek yang dibagi menjadi lima kelompok, yaitu kelompok sehat, gingivitis dengan SRP, serta gingivitis dengan SRP yang dikombinasikan dengan gel kolagen konsentrasi 1%, 2%, dan 4%. Kadar MMP-8 saliva diukur untuk menilai respons inflamasi. Hasil uji statistic terdapat efek yang signifikan kolagen gel 1% dan 2% terhadap MMP-8. Gel kolagen 1% dan 2% memodulasi kadar MMP-8 saliva, yang mengindikasikan potensi peran dalam fase remodeling pasca SRP.
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