Effectiveness of Rambutan (Nephelium lappaceum L.) Peel Extract on Creatinine Levels and Kidney Histology Structure of Obese Rats
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Abstract
Obesity is a condition characterized by the accumulation of excess fat in the body that can cause systemic metabolic changes. Rambutan peel is known to be rich in bioactive compounds such as geraniin, corilagin, ellagic acid, and other active compounds. This study aims to analyze the effect of rambutan peel extract on creatinine levels and kidney histology in obese rat models. The experimental research method used a post-test only control group design. A total of 25 male rats were divided into 5 groups: Normal group (K-); Obese group induced by coconut oil and 15% sugar water (K+); Obese group given ellagic acid (T1); Groups T2 and T3 induced by coconut oil and 15% sugar water and rambutan peel extract at doses of 15 mg/kgBW and 30 mg/kgBW. The parameters of this study were creatinine levels and kidney glomerular diameter. Data analysis used one-way ANOVA and Tukey HSD tests. The results of the study showed that rambutan peel extract could significantly reduce creatinine levels and glomerular diameter (p<0.05). The most optimal reduction was shown at a dose of 30 mg/kgBW for both creatinine levels and glomerular diameter. It can be concluded that rambutan peel extract has the potential to reduce creatinine levels and improve glomerular diameter in obese rat models.
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References
Mabrouki L, Rjeibi I, Taleb J, Zourgui L. Cardiac Ameliorative Effect of Moringa oleifera Leaf Extract in High-Fat Diet-Induced Obesity in Rat Model. Biomed Res Int. 2020;2020. DOI: https://doi.org/10.1155/2020/6583603
Pengrattanachot N, Cherngwelling R, Jaikumkao K, Pongchaidecha A, Thongnak L, Swe MT, et al. Atorvastatin attenuates obese-induced kidney injury and impaired renal organic anion transporter 3 function through inhibition of oxidative stress and inflammation. Biochim Biophys Acta - Mol Basis Dis [Internet]. 2020;1866(6):165741. Available from: https://doi.org/10.1016/j.bbadis.2020.165741 DOI: https://doi.org/10.1016/j.bbadis.2020.165741
Editors A, Jia W, Liu F. Obesity : causes , consequences , treatments , and challenges. 2021;13:463–5. DOI: https://doi.org/10.1093/jmcb/mjab056
Fu J, Wang Y, Tan S, Wang J. Effects of Banana Resistant Starch on the Biochemical Indexes and Intestinal Flora of Obese Rats Induced by a High-Fat Diet and Their Correlation Analysis. Front Bioeng Biotechnol. 2021;9(January):1–14. DOI: https://doi.org/10.3389/fbioe.2021.575724
Li L, Ma L, Wen Y, Xie J, Yan L, Ji A, et al. Crude Polysaccharide Extracted From Moringa oleifera Leaves Prevents Obesity in Association With Modulating Gut Microbiota in High-Fat Diet-Fed Mice. Front Nutr. 2022;9(April):1–17. DOI: https://doi.org/10.3389/fnut.2022.861588
Wardhani RAP, Supartono. Uji Efektivitas Antibakteri Ekstrak Kulit Buah Rambutan (Nephelium lappaceum L.) pada Bakteri. Indones J Chem Sci [Internet]. 2015;4(1):46–51. Available from: http://journal.unnes.ac.id/sju/index.php/ijcs
Nugrahaningsih WH, Widyaningrum P. the Effect of Rambutan Peel Extract (Nephelium Lappaceum L.) To Total Leukocytes and Histopathological of Rat Lungs Exposed By Cigarette Smoke. Eff Rambutan Peel Extr (Nephelium Lappaceum L) To Total Leukocytes Histopathol Rat Lungs Expo By Cigar Smoke. 2017;15(2):181–92.
Astuti MP, Lister C, Renaldi MR. The effect of telang flower extract on kidney function and histopathological features of obese rat kidneys. 2024;6(1):58–64. DOI: https://doi.org/10.34012/jpms.v6i1.5453
Xu Q, Li S, Tang W, Yan J, Wei X, Zhou M, et al. The Effect of Ellagic Acid on Hepatic Lipid Metabolism and Antioxidant Activity in Mice. Front Physiol. 2021;12(October). DOI: https://doi.org/10.3389/fphys.2021.751501
Adrianta KA, Satriyasa BK, Wihandani DM, Jawi IM. The Antioxidant Capacity of Peristrophe Bivalvis ( L .) Merr . as. 2021;26(April):35–41. DOI: https://doi.org/10.22146/mot.53861
Hall JE, Mouton AJ, Da Silva AA, Wang Z, Li X, Do Carmo JM. Obesity, kidney dysfunction, and inflammation: interactions in hypertension. Cardiovasc Res. 2021;117(8):1859–76. DOI: https://doi.org/10.1093/cvr/cvaa336
Fauzi NI, Ulfah M, Yunis YF. Efek Antiobesitas Ekstrak Etanol Bawang Dayak (Eleutherine Bulbosa (Mill.) Urb) Pada Tikus Model Obesitas. J Ilm Farm Bahari. 2019;10(2):123. DOI: https://doi.org/10.52434/jfb.v10i2.653
Mayestika P, Hasmira MH. Artikel Penelitian. J Perspekt. 2021;4(4):519. DOI: https://doi.org/10.24036/perspektif.v4i4.466
Abed BA, Jasim WK, Rahi TS. The Physiological Effects of Orlistat and Efficiency Extract of Cinnamon on Renal Functions in Obese Male Rats. IOP Conf Ser Earth Environ Sci. 2025;1449(1). DOI: https://doi.org/10.1088/1755-1315/1449/1/012024
Luthfiya1 I, Puspita1 OS, , Yudhi Nugraha2, 3* FF. Rambutan fruit peel extract reduces abnormal sperm morphology in male wistar rats with obesity. 2023;16(2):347–55. DOI: https://doi.org/10.15408/kauniyah.v16i2.25729
Fahmi MZ, Muhtadi M. Aktivitas Antiobesitas Kombinasi Ekstrak Dari Umbi Porang (Amorphopallus muelleri) Dan Jati Belanda (Guazuma ulmifolia) Pada Model Tikus Obesitas. Usadha J Pharm. 2022;1(3):314–21. DOI: https://doi.org/10.23917/ujp.v1i3.95
Khairunnisa NA, Isdadiyanto S, Sitasiwi J. Buletin Anatomi dan Fisiologi Volume 10 Nomor 1 Februari 2025 Mikroanatomi Ginjal Tikus Putih ( Rattus norvegicus L .) Galur Sprague-Dawley Hiperlipidemia setelah Pemberian Ekstrak Etanol Biji Mahoni ( Swietenia mahagoni L . Jacq ) Kidney Microanatomy of White Rats ( Rattus norvegicus L .) Hyperlipidemia Strain Sprague- Dawley After Administration of Ethanol Extract of Mahogany Seeds ( Swietenia mahagoni L . Jacq ). 2025;10. DOI: https://doi.org/10.14710/baf.10.1.2025.38-47
Hakim AR, Mulia S, Mulia S. Narrative Review : Optimasi Etanol Sebagai Pelarut Senyawa Flavonoid Dan Fenolik Narrative Review : Optimization of Ethanol as a Solvent for Flavonoids and Phenolic Compounds Abstrak.
Chintya A, Sijabat G, Isdadiyanto S, Sitasiwi AJ. Histopatologi Hepar Tikus Dengan Induksi Pakan Tinggi Lemak Setelah Pemberian Biji Mahoni ( Rat Liver Histopathology by Inducing High-Fat Diet After Giving Mahogany Seeds ). 2024;29(3):482–90. DOI: https://doi.org/10.18343/jipi.29.3.482
Saande CJ, Bries AE, Pritchard SK, Nass CA, Reed CH, Rowling MJ, et al. Cumulative Weight Gain in Diet-Induced Obese Rats. J Nutr [Internet]. 2020;150(7):1818–23. Available from: https://doi.org/10.1093/jn/nxaa114 DOI: https://doi.org/10.1093/jn/nxaa114
Anggraini D. Aspek Klinis Dan Pemeriksaan Laboratorium Penyakit Ginjal Kronik. An-Nadaa J Kesehat Masy. 2022;9(2):236. DOI: https://doi.org/10.31602/ann.v9i2.9229
Arifianto D, Adji D, Sutrisno B, Rickyawan N. Renal Histopathology, Blood Urea Nitrogen and Creatinine Levels of Rats With Unilateral Ureteral Obstruction. Ijvs. 2020;1(1):1–9. DOI: https://doi.org/10.22146/ijvs.v1i1.55183
Anggi V, Sudar CP, Tandi J, Wulandari A. Uji Efek Ekstrak Umbi Talas terhadap Kadar Ureum dan Kreatinin Tikus Putih Jantan Yang Diinduksi Streptozotocin. Farmakol J Farm. 2021;18(2):206–16.
Zaetun S, Rohmi R, Oktaviani AD, Srigede L. Correlation of Blood Creatinine Levels with The Result of Urine Sediment Analysis in Chronic Kidney Failure Patient. J Anal Med Biosains. 2024;11(1):23. DOI: https://doi.org/10.32807/jambs.v11i1.339
Rasool S, Geetha T, Broderick TL, Babu JR, Lambert E. High Fat With High Sucrose Diet Leads to Obesity and Induces Myodegeneration. 2018;9(September):1–10. DOI: https://doi.org/10.3389/fphys.2018.01054
Sun Y, Ge X, Li X, He J, Wei X, Du J, et al. High-fat diet promotes renal injury by inducing oxidative stress and mitochondrial dysfunction. Cell Death Dis [Internet]. 2020; Available from: http://dx.doi.org/10.1038/s41419-020-03122-4 DOI: https://doi.org/10.1038/s41419-020-03122-4
Siregar FA, Makmur T, Utara US, Islam U, Utara S. Metabolisme lipid dalam tubuh. 2020;1(2).
Tsuboi N, Okabayashi Y. The Renal Pathology of Obesity: Structure-Function Correlations. Semin Nephrol [Internet]. 2021;41(4):296–306. Available from: https://doi.org/10.1016/j.semnephrol.2021.06.002 DOI: https://doi.org/10.1016/j.semnephrol.2021.06.002
Kang I, Buckner T, Shay NF, Gu L, Chung S. Improvements in Metabolic Health with Consumption of Ellagic Acid and Subsequent Conversion into Urolithins : Evidence and. Adv Nutr [Internet]. 2016;7(5):961–72. Available from: http://dx.doi.org/10.3945/an.116.012575 DOI: https://doi.org/10.3945/an.116.012575
Klongdee S, Klinkesorn U. Optimization of accelerated aqueous ethanol extraction to obtain a polyphenol ‑ rich crude extract from rambutan ( Nephelium lappaceum L .) peel as natural antioxidant. Sci Rep [Internet]. 2022;1–12. Available from: https://doi.org/10.1038/s41598-022-25818-7 DOI: https://doi.org/10.1038/s41598-022-25818-7
Nomor V, Ayu I, Widiasriani P, Nyoman N, Udayani W, Putri GA. Artikel Review : Peran Antioksidan Flavonoid dalam Menghambat Radikal Bebas. 2024;6:188–97. DOI: https://doi.org/10.37311/jsscr.v6i2.27055
Lin X, Li H. Obesity : Epidemiology , Pathophysiology , and Therapeutics. 2021;12(September):1–9. DOI: https://doi.org/10.3389/fendo.2021.706978
Peng P, Zou J, Zhong B, Zhang G, Zou X, Xie T. Protective Effects and Mechanisms of Flavonoids in Renal Ischemia-Reperfusion Injury. 2023;27–36. DOI: https://doi.org/10.1159/000527262
Harefa T, Khairunnisa Z. Uji Efek Nefroprotektif Ekstrak Etanol Daun Kari ( Murraya Koenigii ( L .) Spreng ) Terhadap Kadar Blood Urea Nitrogen ( BUN ) Dan Kreatinin Tikus Putih Jantan Galur Wistar ( Rattus Norvegicus ) Yang Diinduksi Doksorubisin. 2023;2(2). DOI: https://doi.org/10.55606/jurrikes.v2i2.1744
Jiang Z, Wang Y, Zhao X, Cui H, Han M, Ren X, et al. Obesity and chronic kidney disease. Am J Physiol Endocrinol Metab. 2023;324(1):E24–41. DOI: https://doi.org/10.1152/ajpendo.00179.2022
Anatomi B. Efek Pemberian Ekstrak Etanol Daun Mimba ( Azadirachta indica A . Juss .) terhadap Struktur Ren Tikus Putih ( Rattus norvegicus L .) yang Diberi Pakan Tinggi Lemak. 2023;(May).
Samuel SM, Büsselberg D, Chaari A, John OD. Role of flavonoids in controlling obesity : molecular targets and mechanisms. 2023;(May).
Wang M, Wang Z, Chen Y, Dong Y. Kidney Damage Caused by Obesity and Its Feasible Treatment Drugs. Int J Mol Sci. 2022;23(2). DOI: https://doi.org/10.3390/ijms23020747
DD W. Aplikasi terapeutik geranin dari ekstrak kulit rambutan (Nephelium lappaceum) sebagai antihiperglikemik melalui aktivasinya sebagai antioksidan pada diabetes mellitus tipe 2. NurseLine J. 2016;1(1):120-38.