Effectiveness of Healing Second Degree Burns Gel Preparation of bilimbi Extract (Averroa bilimbi L.) Against Male Wistar Rats
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Abstract
Burns are lesions on body tissues that occur due to exposure to heat sources such as fire, chemicals, or electric currents. Bilimbi (Averroa bilimbi L.) is thought to have therapeutic properties to treat burns in male Wistar rats. Burn healing is divided into 3 phases of inflammation, proliferation, and maturation. This study was to prove the ability of the ethanol extract gel preparation of bilimbi in the process of healing burns. Bilimbi extract gel was formulated in three concentration variations, namely 2.5%, 5%, and 10%. Control testing of the preparation included organoleptic, homogeneity, spreadability, viscosity, and adhesion. The bilimbi extract gel preparation with a series of concentrations of 2.5%, 5%, and 10% gave an effect in healing second-degree burns. The percentage data of burn diameter were analyzed using ANOVA. The results of statistical analysis showed that the preparation of ethanol extract gel from star fruit with a concentration of 10% gave a healing effect with a healing percentage of 86% which was almost the same as the positive control. This healing effect is thought to come from the content of star fruit such as alkaloids, flavonoids, saponins.
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References
Zahara V, Afriyeni H, Rizal R. Uji Efektivitas Sediaan Sintetis Dan Herbal Terhadap Percepatan Penyembuhan Luka Bakar Derajat II Pada Tikus Putih Jantan. Sains Farm an Kesehat 2023;01:14.
Noorbakhsh SI, Bonar EM, Polinski R, Amin MS. Educational Case: Burn Injury—Pathophysiology, Classification, and Treatment. Acad Pathol 2021;8:23742895211057240. https://doi.org/10.1177/23742895211057239. DOI: https://doi.org/10.1177/23742895211057239
Akbar MA, Agustina F. Gambaran Perilaku Masyarakat Terhadap Penanganan Luka Bakar Di Rumah. J Kesehat Komunitas 2023;9:21–6. https://doi.org/10.25311/keskom.vol9.iss1.1153. DOI: https://doi.org/10.25311/keskom.Vol9.Iss1.1153
Sanjaya GRW, Linawati NM, Arijana IGKN, Wahyuniari IAI, Wiryawan IGNS. Flavonoid dalam Penyembuhan Luka Bakar pada Kulit. J Sains Dan Kesehat 2023;5:243–9. https://doi.org/10.25026/jsk.v5i2.1247. DOI: https://doi.org/10.25026/jsk.v5i2.1247
Rusnedy R, Febrina M, Sari CP. Uji Aktivitas Wound Healing Ekstrak Etanol Buah Averrhoa bilimbiL. (Belimbing Wuluh) pada Mencit Putih Jantan (Mus musculus). Pharmacon J Farm Indones 2023;20:50–60. https://doi.org/10.23917/pharmacon.v20i1.22677. DOI: https://doi.org/10.23917/pharmacon.v20i1.22677
Kusuma MHP, Rakhmatullah AN, Yunarti A. Uji Aktivitas Antioksidan Ekstrak Etanol 70% Buah Belimbing Wuluh (Averrhoa bilimbi L.) Menggunakan Metode DPPH. J Surya Med 2023;9:27–33. https://doi.org/10.33084/jsm.v9i1.5130. DOI: https://doi.org/10.33084/jsm.v9i1.5130
Dwita L, Ladeska V, Ramadhani A, Augusta D, Saufia R. MANFAAT EKSTRAK ETANOL DAUN REMEK DAGING (Hemigraphis colorata W. Bull) TERHADAP LUKA BAKAR PADA TIKUS. J Tumbuh Obat Indones 2020;13:32–41. https://doi.org/10.22435/jtoi.v13i1.2823. DOI: https://doi.org/10.22435/jtoi.v13i1.2823
Aisyah S, Gumelar AS, Maulana MS, Amalia R. HT. Identifikasi Karakteristik Hewan Vertebrata Mamalia Tikus Putih (Rattus norvegicus) Berdasarkan Morfologi dan Anatominya. J Farm Galen (Galenika J Pharmacy)(e-Journal) 2023;3:93–102.
Prasongko ET, Lailiyah M, Muzayyidin W. Formulasi Dan Uji Efektivitas Gel Ekstrak Daun Kedondong ( Spondias dulcis F .) Terhadap Luka Bakar Pada Tikus Wastar ( Rattus novergicus ). J Wiyata S1 Farm Fak Farm ,Institut Ilmu Kesehat Bhakti, Kesehat Bhakti Wiyata 2020;7(10:27–36.
Muthmainnah B. Skrining Fitokimia Senyawa Metabolit Sekunder dari Ekstrak Etanol Buah Delima (Punica granatum L.) Dengan Metode Uji Warna 2017;XIII:2–4.
Mohammad Zaky, Nita Rusdiana AD. Mohammad Zaky, Nita Rusdiana Kurniasih, Ayunda Darmawati 2021 2021;VIII:26–36. DOI: https://doi.org/10.47653/farm.v8i2.556
Susianti N, Juliantoni Y, Hanifa NI. Optimasi Sediaan Gel Ekstrak Buah Belimbing Wuluh (Averrhoa bilimbi L.) Dengan Variasi Basis Karbopol 940 dan CMC-Na. Acta Pharm Indones Acta Pharm Indo 2021;9:44. https://doi.org/10.20884/1.api.2021.9.1.3669. DOI: https://doi.org/10.20884/1.api.2021.9.1.3669
Elfasyari TY, Kintoko K, Nurkhasanah N. Gambaran Penyembuhan Luka Tikus Diabetes Dengan Fraksi Etil Asetat Daun Binahong (Anredera cordifolia (Tenore) Steenis). Talent Conf Ser Trop Med 2018;1:158–61. https://doi.org/10.32734/tm.v1i3.282. DOI: https://doi.org/10.32734/tm.v1i3.282
Balqis U, Masyitha D, Febrina F. Healing Process Of Burns Using Ambarella Leaf (Spondias dulcis F.) and Vaselin in Rats (Rattus norvegicus). J Med Vet 2019;8:114–24. https://doi.org/10.21157/j.med.vet..v8i1.3318. DOI: https://doi.org/10.21157/j.med.vet..v13i1.4310
Hasibuan RA, Bakar L, Nagaoka S. Efektifitas Ekstrak Daun Bidara Laut (Ziziphus mauritiana) terhadap Penyembuhan Luka Bakar pada Tikus Putih (Rattus norvegicus L.) Galur Wistar. J Implementa Husada 2023;4. https://doi.org/10.30596/jih.v4i3.15856. DOI: https://doi.org/10.30596/jih.v4i3.15856
Andayani R, Chismirina S, Kumalasari I. Pengaruh Ekstrak Buah Belimbing Wuluh (Averrhoa Bilimbi) Terhadap Interaksi Streptococcus Sanguinis Dan Streptococcus Mutans Secara In Vitro. Cakradonya Dent J 2014;6:678–744.
Veterinaria JM, Balqis U, Masyitha D, Patologi L, Kedokteran F, Universitas H, et al. Proses Penyembuhan Luka Bakar dengan Gerusan Daun Kedondong (Spondias dulcis) dan Vaselin pada Tikus Putih (Rattus norvegicus) Secara Histopatologis. J Med Veterania 2011;8:9–14.
Irianto IDK, Purwanto P, Mardan MT. Aktivitas Antibakteri dan Uji Sifat Fisik Sediaan Gel Dekokta Sirih Hijau (Piper betle L.) Sebagai Alternatif Pengobatan Mastitis Sapi. Maj Farm 2020;16:202. https://doi.org/10.22146/farmaseutik.v16i2.53793. DOI: https://doi.org/10.22146/farmaseutik.v16i2.53793
Irmaneisa E, Witjahjo RBB, Bagiana IK. Pengaruh Perbedaan Konsentrasi Ekstrak Etanol Daun Awar-awar (Ficus septic Burm F.) dalam Sediaan Gel pada Karakteristik Fisik Sediaan dan Penyembuhan Luka Bakar Kulit Kelinci secara Makroskopis Mikroskopis. Media Farm Indones 2019;14:1442–7.
Setyopuspito Pramitaningastuti A. Uji Efektivitas Antiinflamasi Ekstrak Etanol Daun Srikaya (Annona Squamosa. L) Terhadap Edema Kaki Tikus Putih Jantan Galur Wistar. J Ilm Farm 2017;13:8–14. https://doi.org/10.20885/jif.vol13.iss1.art2. DOI: https://doi.org/10.20885/jif.vol13.iss1.art2
Galomat DE, de Queljoe E, Datu OS, Studi Farmasi FMIPA UNSRAT Manado P. Effect Of Giving Centella (Centella asiatica) (L) Urb) Leaves Extract Ointment On Wound Healing Of Male White Rats (Rattus norvegicus). Pharmacon 2020;10:1205–14.
Priamsari MR, Yuniawati NA. Skrining Fitokimia dan Aktivitas Penyembuhan Luka Bakar Ekstrak Etanolik Morinda Citrifolia L. pada Kulit Kelinci (Oryctolagus Cuniculus). J Farm (Journal Pharmacy) 2019;8:22–8. https://doi.org/10.37013/jf.v1i8.76. DOI: https://doi.org/10.37013/jf.v1i8.76