The relationship between the severity of vitiligo and the quality of life of vitiligo patients in North Aceh Hospital
Article Sidebar
Main Article Content
Page: 1078-1090
Abstract
Vitiligo is an autoimmune disease that causes skin depigmentation through T-mediated destruction of melanocytes. The prevalence of vitiligo in Indonesia is currently around 0.1-2%. Skin depigmentation causes physical, psychological, and functional disorders in sufferers that can reduce quality of life. This study aims to analyze the relationship between the severity of vitiligo and quality of life. This research method is quantitative research with a cross-sectional study approach. The sampling technique is purposive sampling. The sample of this study consisted of 34 samples. The severity of vitiligo was measured using the Vitiligo Area Scoring Index (VASI) instrument and quality of life was measured using the validated Vitiligo Quality Of Life (VitiQOL) questionnaire. The results of the study obtained the characteristics of respondents in the study dominated by adult age (19-59 years) as many as 17 people (50%), female gender as many as 27 people (79.4%), last high school education as many as 17 people (50%) and vitiligo classification Non Segmental Vitiligo as many as 22 people (64.7%). Bivariate analysis using the Spearman correlation test obtained a p-value of 0.505 and a correlation coefficient (r) of -0.118. The conclusion of this study is that there is no relationship between the severity of vitiligo and the quality of life of vitiligo patients at the North Aceh Hospital
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
References
World health organization. QOL definition. 1 Maret 2012 2012. DOI: https://doi.org/10.7591/cornell/9780801450655.003.0001
Health Related Quality Of Life. Cent Dis Control Prev 2022.
Deane kevin D. precision medicine in autoimmune disease. SciencedirectCom 2021. DOI: https://doi.org/10.1016/B978-0-12-820239-5.00005-X
Miller FW. The increasing prevalence of autoimmunity and autoimmune diseases: an urgent call to action for improved understanding, diagnosis, treatment, and prevention. Curr Opin Immunol 2023;80:1–16. https://doi.org/10.1016/j.coi.2022.102266. DOI: https://doi.org/10.1016/j.coi.2022.102266
global autoimmune institue. Menjembatani Kesenjangan dalam Diagnosis, Pengobatan, dan Kesadaran Penyakit Autoimun. Glob Autoimmune Inst 2024.
Desai MK, Brinton RD. Autoimmune disease in women: Endocrine transition and risk across the lifespan. Front Endocrinol (Lausanne) 2019;10. https://doi.org/10.3389/fendo.2019.00265. DOI: https://doi.org/10.3389/fendo.2019.00265
National Institutes of Health, MedlinePlus NI of A and M and SD. common autoimmune disease. Natl Libr Med 2023.
Masykurin SB, Febria Wardani A, Pramuningtyas R, Kedokteran F, Surakarta UM, Muhammadiyah Surakarta U, et al. The Correlation Of Vitiligo With Depression Degrees And Level Of Quality Of Life 2018:486–502.
Tuyen NT, Doanh N Van, Huong NTM. Impact of Vitiligo on Quality of Life. Tạp Chí Da Liễu Học Việt Nam 2022;33:55–60. https://doi.org/10.56320/tcdlhvn.v33i.66. DOI: https://doi.org/10.56320/tcdlhvn.v33i.66
Frączek A, Owczarczyk-Saczonek A, Placek W. The role of TRM cells in the pathogenesis of vitiligo—a review of the current state-of-the-art. Int J Mol Sci 2020;21. https://doi.org/10.3390/ijms21103552. DOI: https://doi.org/10.3390/ijms21103552
Kang S, Amagai M, Bruckner anna l., Enk alexander h., Margolis david j., McMichael amy j., et al. Fitzpatrick’s Dermatology 9th Edition. 9th editio. McGraw Hill Education; 2019.
Hidayati A, Maulida M, Earlia N, Liana MR. Hubungan Derajat Keparahan Area Vitiligo dengan Tingkat Depresi pada Pasien Vitiligo di Poliklinik Kulit dan Kelamin Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh. J Med Sci 2023;4:8–16. https://doi.org/https://rsudza.acehprov.go.id/publikasi/index.php/JMS/article/view/75. DOI: https://doi.org/10.55572/jms.v4i1.75
Dockins P. vitiligo facts. Glob Vitiligo Found 2019.
Hlača N, Žagar T, Kaštelan M, Brajac I, Prpić-Massari L. Current Concepts of Vitiligo Immunopathogenesis. Biomedicines 2022;10. https://doi.org/10.3390/biomedicines10071639. DOI: https://doi.org/10.3390/biomedicines10071639
Info Sehat FKUI. Penderita Vitiligo Tak Harus Rendah Diri, Mereka Juga Bisa Berprestasi 2021.
Saiboo AA, Rosita C, Prakoeswa S, Indramaya DM, Nurul A. Characteristics and Clinical Profile of Vitiligo Patients in Dermatology and Venereology Outpatient Clinic Unit at Dr . Soetomo General Academic Hospital Surabaya Budi 2023;35:1–5. DOI: https://doi.org/10.20473/bikk.V35.1.2023.1-5
Rahim Zar A, Malik A, Mahmood A, Ahmad Naseer Q, Yumei L. Pathogenesis and the emerging Therapy of Vitiligo. Arch Clin Biomed Res 2019;03:361–73. https://doi.org/10.26502/acbr.50170080. DOI: https://doi.org/10.26502/acbr.50170080
Naldi L, Pagani A, Alduini C. Vitiligo : Epidemiology and Economic Impact 2023;13:1–8. DOI: https://doi.org/10.5826/dpc.1304S2a315S
Zainuddin AA, Faqih DM, Trisna DV, Waluyo DA, Ekayanti F, Hariyani I, et al. Panduan Praktik Klinis. Jakarta: PERDOSKI; 2017.
Kovacevic M, Stanimirovic A, Vucic M, Goren A, Situm M, Lukinovic Skudar V, et al. Mixed vitiligo of Blaschko lines: a newly discovered presentation of vitiligo responsive to combination treatment. Dermatol Ther 2016;29:240–3. https://doi.org/10.1111/dth.12345. DOI: https://doi.org/10.1111/dth.12345
Bibeau K, Pandya AG, Ezzedine K, Jones H, Gao J, Lindley A, et al. Vitiligo prevalence and quality of life among adults in Europe, Japan and the USA. J Eur Acad Dermatology Venereol 2022:1831–44. https://doi.org/10.1111/jdv.18257. DOI: https://doi.org/10.1111/jdv.18257
Asri E, Kampar P. Hubungan Vitiligo Area Scoring Index (Vasi) dengan Dermatology Life Quality Index (Dlqi) pada Pasien Vitiligo di RSUP Dr. M. Djamil Padang Periode 2015-2016. J Kesehat Andalas 2019;8:506. https://doi.org/10.25077/jka.v8i3.1034. DOI: https://doi.org/10.25077/jka.v8i3.1034
Bibeau K, Ezzedine K, Harris JE, Van Geel N, Grimes P, Parsad D, et al. Mental Health and Psychosocial Quality-of-Life Burden among Patients with Vitiligo: Findings from the Global VALIANT Study. JAMA Dermatology 2023;159:1124–8. https://doi.org/10.1001/jamadermatol.2023.2787. DOI: https://doi.org/10.1001/jamadermatol.2023.2787
Hedayat K, Karbakhsh M, Ghiasi M, Goodarzi A, Fakour Y, Akbari Z, et al. Quality of life in patients with vitiligo: A cross-sectional study based on Vitiligo Quality of Life index (VitiQoL). Health Qual Life Outcomes 2020;14:1–9. https://doi.org/10.1186/s12955-016-0490-y. DOI: https://doi.org/10.1186/s12955-016-0490-y
Merhi R, Cnu D, Barnetche T, Deuchez E. Assessment of Vitiligo Area Scoring Index (VASI), Facial‐VASI and Vitiligo Extent Score using standardized photography of patients with vitiligo. Br J Dermatol 2022;187:422–4. https://doi.org/https://doi.org/10.1111/bjd.21246. DOI: https://doi.org/10.1111/bjd.21246
Hasan Z, Pathania YS. J of Cosmetic Dermatology - 2024 - Hasan - Late‐Onset Vitiligo Epidemiology Clinical Characteristics and Management.pdf 2024. https://doi.org/https://doi.org/10.1111/jocd.16705. DOI: https://doi.org/10.1111/jocd.16705
Molla A, Allayoubi AM, Raed, Jannadi. First Cousin Marriages and the Risk of Childhood-Onset Vitiligo: Exploring the Genetic Background: A Cross-Sectional Study. Dove Med Press 2024;17. https://doi.org/10.2147/CCID.S470937. DOI: https://doi.org/10.2147/CCID.S470937
Lazzeri L, Colucci R, Cammi A, Dragoni F, Moretti S. Adult Onset Vitiligo: Multivariate Analysis Suggests the Need for a Thyroid Screening. Biomed Res Int 2018;2018. https://doi.org/10.1155/2016/8065765. DOI: https://doi.org/10.1155/2016/8065765
Spritz RA, Santorico SA. The Genetic Basis of Vitiligo. J Invest Dermatol 2021;141:265–73. https://doi.org/10.1016/j.jid.2020.06.004. DOI: https://doi.org/10.1016/j.jid.2020.06.004
Akl J, Lee S, Jeong H, Parisi R, Yoon J, Joon J. Estimating the Burden of Vitiligo: A Systematic Review and Modelling Study. Lancet Public Heal 2024;9. https://doi.org/10.1016/S2468-2667(24)00026-4. DOI: https://doi.org/10.1016/S2468-2667(24)00026-4
Husseiny R, Elhaleem A, Saleh W, Abdullah M. Childhood Vitiligo in Egypt: Clinico-epidemiologic Profile of 483 Patients. J Cosmet Dermatol 2020;20:237–42. https://doi.org/https://doi.org/10.1111/jocd.13451. DOI: https://doi.org/10.1111/jocd.13451
Taneja N, Sreenivas, Sahni K, Gupta V, Ramam. Disease Stability in Segmental and Non Segmental Vitiligo. Indian Dermatol Online J 2022. https://doi.org/10.4103/idoj.IDOJ_154_21. DOI: https://doi.org/10.4103/idoj.IDOJ_154_21
Mahajan VK, Verma YR, Mehta KS, Chauhan PS. dults with a more extensive body involvement, moderate to extremely severe vitiligo and a prolonged clinical course have an early onset in childhood in addition to other prognostic factors as compared to individuals with later-onset vitiligo. Australas J Dermatol 2020. https://doi.org/https://doi.org/10.1111/ajd.13417. DOI: https://doi.org/10.1111/ajd.13417
Pengpid S, Peltzer K. The impact of chronic diseases on the quality of life of primary care patients in Cambodia, Myanmar and Vietnam. Iran J Public Health 2018;47:1307–15.
Aji AS, Widodo A. Perilaku Pencarian Pengobatan terhadap Penyakit Tidak Menular pada Masyarakat. J Telenursing 2023;5:641–9. https://doi.org/10.31539/joting.v5i1.5606. DOI: https://doi.org/10.31539/joting.v5i1.5606
Swarty G, Nauli FA, Jumaini J. Hubungan Kepercayaan Keluarga Pasien Tentang Kesehatan Jiwa Terhadap Pencarian Pengobatan Formal Gangguan Jiwa. J Ners Indones 2022;13:88–95. https://doi.org/10.31258/jni.13.1.88-95. DOI: https://doi.org/10.31258/jni.13.1.88-95
Bhakti Wiranti. Urgensi Aspek Psikodermatologi dalam Perawatan Kulit: Memahami Keterkaitan Emosi dan Kesehatan Kulit. Mutiara J Ilm Multidisiplin Indones 2024;2:224–44. https://doi.org/10.61404/jimi.v2i1.175. DOI: https://doi.org/10.61404/jimi.v2i1.175
Dehnavi AZ, Daneshpazhooh M, Dehghani A, Balighi K, Azizpour A, Yaseri M, et al. Stigma Experience in Patients With Vitiligo: A Comprehensive Study in a Skin Hospital. Acta Med Iran 2022;60:422–8. https://doi.org/10.18502/acta.v60i7.10214. DOI: https://doi.org/10.18502/acta.v60i7.10214
Suseno LS, Sukma PMG, Rihatmadja R, Agustin T, Rahmayunita G, Novianto E. Profile of vitiligo patients and distribution of narrowband-UVB therapy at dr. Cipto Mangunkusumo General Hospital. J Gen Dermatology Venereol Indones 2018;3:29–33. https://doi.org/10.19100/jdvi.v3i1.132. DOI: https://doi.org/10.19100/jdvi.v3i1.132
Circadian clock gene expression and polymorphism in non-segmental vitiligo. Farag AGA Badr EAE Ibrahim AF 2024. https://doi.org/10.1007/s11033-023-09109-6. DOI: https://doi.org/10.1007/s11033-023-09109-6
Moftah NH, Alnos H, Rashed L, Hamdino M. Evaluation of serum and tissue levels of cold‑inducible RNA‑binding.pdf 2023. DOI: https://doi.org/10.1007/s00403-023-02586-6
Li S, Dai W, Wang S, Kang P, Ye Z, Han P, et al. Clinical Significance of Serum Oxidative Stress Markers to Assess Disease Activity and Severity in Patients With Non-Segmental Vitiligo. Front Cell Dev Biol 2021;9:1–10. https://doi.org/10.3389/fcell.2021.739413. DOI: https://doi.org/10.3389/fcell.2021.739413
Cabrera R, Hojman L, Recule F, Sepulveda R, Delgado I. Predictive model for response rate to narrowband ultraviolet B phototherapy in vitiligo: A retrospective cohort study of 579 patients. Acta Derm Venereol 2019;98:416–20. https://doi.org/10.2340/00015555-2889. DOI: https://doi.org/10.2340/00015555-2889
Shaikh FM, Pirzado MS, Bashir H, Kalhoro Ah, Memon A, Malkani M, et al. Occurrence Of Segmental And Non Segmental Vitiligo At Tertiary Care Hospital. Forum Linguist Study 2023;5.
Saumya P, Shyam V. Validation of the diagnostic criteria for segmental vitiligo. Indian J Dermatol Venereol Leprol 2020;84:6–15. https://doi.org/10.4103/ijdvl.IJDVL.
Geetha K, Upadhyaya A, Singh S. Clinical study of vitiligo with assessment of quality of life and comparison with Vitiligo Area Severity Index score in a tertiary care center in northern India. Pigment Int 2024:1–6. https://doi.org/10.4103/pigmentinternational_11_24. DOI: https://doi.org/10.4103/pigmentinternational_11_24
Awal G, Kaur N, Singh G, Sharma N. Impact of Vitiligo on Quality of Life in Patients of Skin of Color and Its Correlation With Clinical Severity Assessment Scores Utilizing Disease Specific Scores: A Cross-Sectional Study. Dermatology Pract Concept 2024;14:1–11. https://doi.org/10.5826/dpc.1402a75. DOI: https://doi.org/10.5826/dpc.1402a75
Chen J, Guo W, Du P, Cui T, Yang Y, Wang Y, et al. MIF inhibition alleviates vitiligo progression by suppressing CD8+ T cell activation and proliferation. J Pathol 2023;260:84–96. https://doi.org/10.1002/path.6073. DOI: https://doi.org/10.1002/path.6073
Rosmarin D, Soliman AM, Piercy J, Marwaha S, Anderson P, Camp HS. Health-Related Quality of Life Burden Among Adults with Vitiligo: Relationship to Disease Severity and Disease Location. Dermatol Ther (Heidelb) 2024;14:1633–47. https://doi.org/10.1007/s13555-024-01187-z. DOI: https://doi.org/10.1007/s13555-024-01187-z
abdou E ebrahim, Abdel sabour MH, Elmowafy RE, Mohamed MA. Assessment of Quality of Life for Vitiligo Patients and Its Associated Factors: A Descriptive Study. Port Said Sci J Nurs 2024;11:1–28. https://doi.org/10.21608/pssjn.2024.271565.1297. DOI: https://doi.org/10.21608/pssjn.2024.271565.1297
Tabassum S, Rahman A, Ghafoor R, Khan Q, Ahmed N, Amber T, et al. Quality of Life Index in Patients with Vitiligo. J Coll Physicians Surg Pakistan 2023;33:521–6. https://doi.org/10.29271/jcpsp.2023.05.521. DOI: https://doi.org/10.29271/jcpsp.2023.05.521
Topal IO, Duman H, Goncu OEK, Durmuscan M, Gungor S, Ulkumen PK. Knowledge, beliefs, and perceptions of Turkish vitiligo patients regarding their condition. An Bras Dermatol 2023;91:770–5. https://doi.org/10.1590/abd1806-4841.20165060. DOI: https://doi.org/10.1590/abd1806-4841.20165060
Belgaumkar VA, Chavan RB, Deshmukh NS, Warke NV. Impact of Vitiligo on Quality of Life: A Cross-sectional Pilot Study from Western India. J Ski Stem Cell 2020;7. https://doi.org/10.5812/jssc.107184. DOI: https://doi.org/10.5812/jssc.107184
Joshua Jota Romadhona. Hubungan antara Derajat Keparahan Vitiligo Terhadap Indeks Kualitas Hidup dalam Dermatologi Penderita Vitiligo 2019.
Elsayed RM, Mahmoud ED, Mostafa HA. Correlation between psychological problems, self-esteem and quality of life among vitiligo patients. Int J Nov Res Healthc Nurs 2021;8:727–43.