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Vika Rizky Dwi Septyani
Septian Maulid Wicahyo
Danang Raharjo

Page: 588-599

Abstract

Skin is one of the organs that serve to protect the body from external influences. Exposure to free radicals causes skin damage, so antioxidant compounds are needed. Baby corn (Zea mays L.) hair contains flavonoids that have the potential to be antioxidants so that they can be formulated into an optimum serum preparation. This experimental study aims to determine the optimal formula concentration and antioxidant activity of anti-aging serum preparation of ethanol extract of Hair (Zea Mays L.). The optimum formula was obtained from the data analysis of Design Expert 13 Simplex Lattice Design method with variations in the concentration of Karbopol and TEA. The results showed that the variation of Karbopol and TEA concentrations affected the physical quality evaluation. The desirability value was 0.903, and the optimum formula concentration was obtained at Karbopol 1.7795% and TEA I2.294%. Data analysis of the optimum formula using the Shapiro-Wilk Normality Test and One Sample T-Test Test resulted in normally distributed data and no significant difference with the predicted value. The antioxidant activity test result of the optimum formula was 65.08 μg/ml with a strong category.

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How to Cite
Dwi Septyani, V. R., Wicahyo , S. M., & Raharjo , D. (2024). Optimization of Antiaging Serum Preparation with Ethanol Extract for Baby Corn (Zea Mays L.) Hair. Journal of Pharmaceutical and Sciences, 7(4), 588–599. https://doi.org/10.36490/journal-jps.com.v7i4.622
Section
Original Articles

References

A. Haerani, A. Y. Chaerunisa, and A. Subarnas, “Artikel Tinjauan: Antioksidan Untuk Kulit,” Farmaka, vol. 16, no. 2, pp. 135–151, 2018.

S. D. Vijitha T P, “Corn Silk- A Medicinal Boon,” Int. J. ChemTech Res., vol. 10, no. 10, pp. 129–137, 2017.

E. D. Wijayanti, N. C. E. Setiawan, and J. P. Christi, “Effect of Lactic Acid Fermentation on Total Phenolic Content and Antioxidant Activity of Fig Fruit Juice (Ficus carica),” Heal. Sci. Int. Conf., vol. 2, no. Hsic, pp. 282–289, 2017, doi: 10.2991/hsic-17.2017.44. DOI: https://doi.org/10.2991/hsic-17.2017.44

A. Fajrina, D. D. A. Bakhtra, A. Eriadi, W. C. Putri, and S. Wahyuni, “Uji Aktivitas Antibakteri Ekstrak Etanol Rambut Jagung (Zea mays L.) Terhadap Bakteri Streptococcus mutans dan Porphyromonas gingivalis,” J. Farm. Higea, vol. 13, no. 2, p. 155, 2021, doi: 10.52689/higea.v13i2.391. DOI: https://doi.org/10.52689/higea.v13i2.391

Y. Anas and N. A. Hatimah, “Efek Antihipertensi Ekstrak Etanol Kombinasi Rambut dan Biji Jagung (Zea mays L.) pada Tikus Hipertensi yang Diinduksi Monosodium Glutamat,” JIFFK J. Ilmu Farm. dan Farm. Klin., vol. 15, no. 01, p. 29, 2018, doi: 10.31942/jiffk.v15i01.2170. DOI: https://doi.org/10.31942/jiffk.v15i01.2170

N. Aulyawati, Yahdi, and N. Suryani, “Skrining fitokimia dan aktivitas antioksidan ekstrak etanol rambut jagung manis (Zea mays ssaccharata strurf) menggunakan metode DPPH,” J. Kim. Pendidik. Kim., vol. 3, no. 2, pp. 132–142, 2021, doi: 10.20414/spin.v3i2.4101.

H. F. Hidayah, “Optimasi Sediaan Dan Stabilitas Fisik Serum Kombucha Daun Teh Hijau (Camellia sinensis),” Univ. Islam Sultan Agung, p. 13, 2023, [Online]. Available: https://www.ncbi.nlm.nih.gov/books/NBK558907/

Wimpy, T. Harningsih, and W. Larassati, “Uji Aktivitas Antioksidan Dan Tabir Surya Kombinasi Ekstrak Kulit Buah Pisang Kepok (Musa Paradisiaca Linn) Dan Ekstrak Kulit Buah Alpukat (Persea Americana Mill),” J. Ilm. Manuntung, vol. 6, no. 2, pp. 231–239, 2020.

F. N. Liandhajani and A. Padua Ratu, “Karakteristik Dan Stabilitas Sediaan Serum Ekstrak Buah Kersen (Muntingia calabura L.) dengan Variasi Konsentrasi,” J. Farmamedika (Pharmamedica Journal), vol. 7, no. 1, pp. 17–27, 2022, doi: 10.47219/ath.v7i1.140. DOI: https://doi.org/10.47219/ath.v7i1.140

Dyera Forestryana, Yuliani, and Aristha Novyra Putri, “OPTIMASI FORMULA SEDIAAN KRIM EKSTRAK ETANOL 95% DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.),” Borneo J. Pharmascientech, vol. 4, no. 1, pp. 22–31, 2020, doi: 10.51817/bjp.v4i1.274. DOI: https://doi.org/10.51817/bjp.v4i1.274

P. C. Shanti, “FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN EMULGEL MINYAK ATSIRI BUNGA CENGKEH MENGGUNAKAN METODE (1,1- Difenil-2-Pikrilhidrazil),” Skripsi. p. 55, 2019.

N. Lestari, “UJI AKTIVITAS ANTIOKSIDAN JUS LABU SIAM YANG DIKOMBINASIKAN DENGAN MADU MENGGUNAKAN METODE DPPH ( 2,2-difenil-1-pikrilhidrazil ) SKRIPSI,” Skripsi, 2021.

I. A. Putri, “Skrining Fitokimia dan Uji Aktivitas Antioksidan Ekstrak Etanol 70% Batang Nilam (Pogostemon cablin Benth.) dengan Metode DPPH,” Indones. J. Pharm. Sci. Clin. Res., vol. 1, no. 2, pp. 1–16, 2023. DOI: https://doi.org/10.59638/junomefar.v1i1.592

A. A. Bakti, L. Triyasmono, and M. I. Rizki, “Penentuan Kadar Flavonoid Total dan Uji Antioksidan Ekstrak Etanol Daun Kasturi (Mangifera casturi Kosterm.) dengan Metode DPPH,” J. Pharmascience, vol. 4, no. 1, pp. 102–108, 2017, doi: 10.20527/jps.v4i1.5762. DOI: https://doi.org/10.20527/jps.v4i1.5762

D. K. Membri, A. Yudistira, and S. S. Abdullah, “UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL SPONS Liosina paradoxa YANG DIKOLEKSI DARI PULAU MANTEHAGE,” Pharmacon, vol. 10, no. 2, p. 774, 2021, doi: 10.35799/pha.10.2021.34024. DOI: https://doi.org/10.35799/pha.10.2021.34024

K. Kurnia, M. Yunus, and N. Herawati, “Uji Aktivitas Antioksidan Ekstrak Etanol Rambut Jagung (Zea mays L.) dengan Menggunakan Metode 2,2-difenil-1-pikrilhidrazil (DPPH),” Chem. J. Ilm. Kim. dan Pendidik. Kim., vol. 22, no. 2, p. 69, 2021, doi: 10.35580/chemica.v22i2.26210. DOI: https://doi.org/10.35580/chemica.v22i2.26210

Wardani Indah Mahendra and Vifta Rissa Laila, “Potensi Antioksidan dan Tabir Surya Ekstrak dan Sediaan Krim Rambut Jagung (Zea mays L.),” J. Holistics Heal. Sci., vol. 3, no. 2, pp. 233–245, 2021, doi: 10.35473/jhhs.v3i2.92. DOI: https://doi.org/10.35473/jhhs.v3i2.92

I. Y. Yudhianto, E. S. Rejeki, and D. Ekowati, “Optimasi Formula Gel Ekstrak Apel (Pyrus malus L.) sebagai Antioksidan dengan Kombinasi Basis Metil Selulosa dan Gliserin Secara Simplex Latice Design,” Biomedika, vol. 6, no. 2, pp. 7–13, 2013.