Main Article Content

Afrizal Mubarok
Tista Ayu Fortuna

Page: 2208-2218

Abstract

Background: Chronic kidney disease (CKD) is a condition characterized by impaired kidney function lasting at least three months. In patients with chronic kidney failure, the use of multiple medications has the potential to increase the risk of drug-related problems (DRPs), which can hinder the expected effectiveness of therapy. Objective: This study aims to determine the incidence of DRPs in patients with chronic kidney disease treated at the inpatient facility of Hospital X in Surakarta. Methods: This study employed a cross-sectional methodology and a non-experimental design. Data were collected retrospectively through the medical records of patients with chronic kidney disease treated at the inpatient facility of Hospital X in Surakarta. Data analysis was performed univariately by describing and analyzing the study variables. DRPs were identified based on the Pharmaceutical Care Network Europe (PCNE) classification. Results: The most common comorbidity was anemia at 27.93%, while the most frequently used drug class was vitamins and minerals at 24.70%. Of the 108 patients analyzed, 12 patients experienced at least one DRP (11.11%). In total, 15 cases of DRPs were identified with code P1.3 (problem) and codes C3.1, C3.2, C3.3, and C3.4 (causes) from those 12 patients. Conclusion: This study shows the occurrence of DRPs in patients with chronic kidney disease treated at Hospital X in Surakarta.

Downloads

Download data is not yet available.

Article Details

How to Cite
Mubarok, A., & Fortuna, T. A. (2025). Identification of Drug-Related Problems among Chronic Kidney Disease Patients Hospitalized at X Hospital Surakarta in 2024. Journal of Pharmaceutical and Sciences, 8(4), 2208–2218. https://doi.org/10.36490/journal-jps.com.v8i4.1075
Section
Original Articles

References

Dipiro JT, Tee GC, Haines ST, Nolin TD, Ellingrod VL, Posey LM. Dipiro’S Pharmacotherapy a Pathophysiologic Approach 12Th Edition. 2023.

Bikbov B, Purcell C, Levey AS, Smith M, Abdoli A, Abebe M, et al. Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet 2020;395:709–33. https://doi.org/10.1016/S0140-6736(20)30045-3. DOI: https://doi.org/10.1016/S0140-6736(20)30045-3

Goh JX, Tesfaye W, Van C, Sud K, Seth S, Tarafdar S, et al. The Impact of Medication Regimen Complexity on Patient-Related and Clinical Outcomes in Patients Undergoing Hemodialysis. Hemodialysis International 2025;29:231–6. https://doi.org/10.1111/hdi.13214. DOI: https://doi.org/10.1111/hdi.13214

Cipolle RJ, Strand LM, Morley PC. Pharmaceutical Care Practice: The Patient-Centered Approach to Medication Management Services, 3rd Edition. 3rd ed. New York, USA: McGraw-Hill Medical; 2012.

PCNE. PCNE Classification for Drug-Related Problems V9.1. PCNE Association 2020;1:22–8.

Juwita DA, Rachmaini F, Abdillah R, Meliani M. Drugs Related Problems (DRPs) Pada Pasien Penyakit Ginjal Kronik (PGK) Di RSUP Dr. M. Djamil. Jurnal Sains Farmasi & Klinis 2023;9:184. https://doi.org/10.25077/jsfk.9.sup.184-189.2022. DOI: https://doi.org/10.25077/jsfk.9.sup.184-189.2022

Indarto, Novitasari M, Yulianto DJ, Agustina DT, Sakka L. SENTRI : Analisa DRPs Kategori PCNE Pada Pasien Gagal Ginjal Akut Dengan Infeksi Tanpa Hemodialisis Di Rawat Inap RSUD Dr . Moewardi 2025;4:1162–74. DOI: https://doi.org/10.55681/sentri.v4i8.4340

PERNEFRI. 13th Annual Report of Indonesian Renal Registry 2020. Indonesian Renal Registry (IRR) 2020;13:11.

Fitriani D, Pratiwi RD, Saputra R, Haningrum KS. Hubungan Lama Menjalani Terapi Hemodialisis Dengan Kualitas Hidup Pasien Penyakit Ginjal Kronik Di Ruang Hemodialisa Rumah Sakit Dr Sitanala Tangerang. Edu Dharma Journal: Jurnal Penelitian Dan Pengabdian Masyarakat 2020;4:70. https://doi.org/10.52031/edj.v4i1.44. DOI: https://doi.org/10.52031/edj.v4i1.44

Artiany S, Gamayana Trimawang Aji Y. Gambaran Komorbid pada Pasien Hemodialisis di Rumah Sakit Angkatan Udara (RSAU) drEsnawan Antariksa. Jurnal Keperawatan Cikini 2021;2:1–6. https://doi.org/10.55644/jkc.v2i2.57. DOI: https://doi.org/10.55644/jkc.v2i2.57

Sinaga CR. DOI: http://dx.doi.org/10.33846/sf14209 EQ-5D-5L untuk Pengukuran Biaya dan Indeks Utilitas pada Pasien Gagal Ginjal Kronik dengan Hemodialisis Clara Ritawany Sinaga 2023;14:286–90.

Dewi NKS, Maharianingsih NM. Evaluasi Penggunaan Obat Anemia Pada Pasien Penyakit Ginjal Kronik Dengan Hemodialisa Di Rsu Ari Canti Pada Tahun 2020. MEDFARM: Jurnal Farmasi Dan Kesehatan 2021;10:1–12. https://doi.org/10.48191/medfarm.v10i2.58. DOI: https://doi.org/10.48191/medfarm.v10i2.58

Megawati S, Sopiahani S, Fathonah N. Identifikasi Drug-Related Problems ( DRPs ) pada Pasien Gagal Ginjal Kronik di Instalasi Rawat Inap RSUP Dr . Sitanala Tangerang Tahun 2019-2021 Identifikasi Drug Related Problems ( DRPs ) Pada Pasien Gagal Ginjal Kronik … 2024;10:70–5. https://doi.org/10.36733/medicamento.v10i2.7006. DOI: https://doi.org/10.36733/medicamento.v10i2.7006

Ameer OZ. Hypertension in chronic kidney disease: What lies behind the scene. Frontiers in Pharmacology 2022;13:1–28. https://doi.org/10.3389/fphar.2022.949260. DOI: https://doi.org/10.3389/fphar.2022.949260

Narsa AC, Maulidya V, Reggina D, Andriani W, Rijai HR. Studi Kasus: Pasien Gagal Ginjal Kronis (Stage V) dengan Edema Paru dan Ketidakseimbangan Cairan Elektrolit. Jurnal Sains Dan Kesehatan 2022;4:17–22. https://doi.org/10.25026/jsk.v4ise-1.1685. DOI: https://doi.org/10.25026/jsk.v4iSE-1.1685

Al Kamaliah NI, Cahaya N, Rahmah S. Gambaran Karakteristik Pasien Gagal Ginjal Kronik Yang Menggunakan Suplemen Kalsium di Poliklinik Sub Spesialis Ginjal Hipertensi Rawat Jalan RSUD Ulin Banjarmasin. Jurnal Pharmascience 2021;8:111. https://doi.org/10.20527/jps.v8i1.8599. DOI: https://doi.org/10.20527/jps.v8i1.8599

Makmur SA, Madania M, Rasdianah N. Gambaran Interaksi Obat Pada Pasien Gagal Ginjal Kronik Dalam Proses Hemodialisis. Indonesian Journal of Pharmaceutical Education 2022;2:218–29. https://doi.org/10.37311/ijpe.v2i2.13333. DOI: https://doi.org/10.37311/ijpe.v2i2.13333

Fajriansyah F, Nisa M. Evaluasi Tingkat Kepatuhan Penggunaan Obat Antihipertensi Pada Pasien Penyakit Ginjal Kronik Lanjut Usia. Jurnal Ilmiah Manuntung 2018;3:178–85. https://doi.org/10.51352/jim.v3i2.125. DOI: https://doi.org/10.51352/jim.v3i2.125

Rudang SN, Rambe RE, Annisa S. Identifikasi Drug Related Problems Pada Pasien Penyakit Ginjal Kronis Di Rumah Sakit Prof. dr. Chairuddin Panusunan Lubis Tahun 2023. Indonesian Journal of Pharmaceutical and Clinical Research 2024;7:34–45. https://doi.org/10.32734/idjpcr.v7i1.18031. DOI: https://doi.org/10.32734/idjpcr.v7i1.18031

Bosi A, Xu Y, Gasparini A, Wettermark B, Barany P, Bellocco R, et al. Use of nephrotoxic medications in adults with chronic kidney disease in Swedish and US routine care. Clinical Kidney Journal 2022;15:442–51. https://doi.org/10.1093/ckj/sfab210. DOI: https://doi.org/10.1093/ckj/sfab210

Zhang Y, He D, Zhang W, Xing Y, Guo Y, Wang F, et al. ACE Inhibitor Benefit to Kidney and Cardiovascular Outcomes for Patients with Non-Dialysis Chronic Kidney Disease Stages 3–5: A Network Meta-Analysis of Randomised Clinical Trials. Drugs 2020;80:797–811. https://doi.org/10.1007/s40265-020-01290-3. DOI: https://doi.org/10.1007/s40265-020-01290-3

Syamsiatun NH, Siswati T. Pemberian ekstra jus putih telur terhadap kadar albumin dan Hb pada penderita hipoalbuminemia. Jurnal Gizi Klinik Indonesia 2015;12:54. https://doi.org/10.22146/ijcn.22919. DOI: https://doi.org/10.22146/ijcn.22919

Wang CH, Jiang MH, Ma JM, Yuan MC, Liao L, Duan HZ, et al. Identification of independent risk factors for hypoalbuminemia in patients with CKD stages 3 and 4: the construction of a nomogram. Frontiers in Nutrition 2024;11. https://doi.org/10.3389/fnut.2024.1453240. DOI: https://doi.org/10.3389/fnut.2024.1453240

Prayulis I, Susanti IH. Asuhan Keperawatan Pola Nafas Tidak Efektif dengan Balloon Blowing pada Pasien Chronic Kidney Disease. Jurnal Penelitian Perawat Profesional 2023;6:503–8. https://doi.org/10.37287/jppp.v6i2.2205. DOI: https://doi.org/10.37287/jppp.v6i2.2205

Nugraha PA, Yasa AAGWP. Anemia Defisiensi Besi: Diagnosis Dan Tatalaksana. Ganesha Medicine 2022;2:49–56. https://doi.org/10.23887/gm.v2i1.47015. DOI: https://doi.org/10.23887/gm.v2i1.47015

Zuliani P, Amita D. Hubungan Anemia dengan Kualitas Hidup Pasien Penyakit Ginjal Kronik yang Menjalani Hemodialisis. Jurnal Keperawatan Muhammadiyah Bengkulu 2020;08:1–1. https://doi.org/10.1007/978-3-642-54672-3_415-1. DOI: https://doi.org/10.37063/jurnalantarakeperawatan.v1i2.20

Das A, Naranje P, Bhalla AS, Das CJ. Imaging of Pulmonary Manifestations in Chronic Kidney Disease: A Review. Indographics 2023;02:10–3. https://doi.org/10.1055/s-0043-1774757. DOI: https://doi.org/10.1055/s-0043-1774757

Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease 2024;105 (Suppl:S117–S314.

Idris NA, Mongan AE, Memah MF. Gambaran kadar kalsium pada pasien penyakit ginjal kronik stadium 5 non dialisis. Jurnal E-Biomedik 2016;4:7–9. DOI: https://doi.org/10.35790/ebm.4.1.2016.10870

Lexicomp. Drug Information Handbook. Hudson, Ohio: Lexicomp / Wolters Kluwer; 2023.

Weking KK, Geografi L, Sinaga CR. Study of Medicine Dosage Adjustments in Inpatients with Chronic Kidney Disease. JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) 2024;14:180. https://doi.org/10.22146/jmpf.88181. DOI: https://doi.org/10.22146/jmpf.88181

Ashley C, Dunleavy A. The renal drug handbook: The ultimate prescribing guide for renal practitioners, 4th edition. 2017. https://doi.org/10.1201/9781315379456. DOI: https://doi.org/10.1201/9780429460418

Kim S, Ko K, Park S, Lee DR, Lee J. Effect of fenofibrate medication on renal function. Korean Journal of Family Medicine 2017;38:192–8. https://doi.org/10.4082/kjfm.2017.38.4.192. DOI: https://doi.org/10.4082/kjfm.2017.38.4.192

Naveed H, Tirumandyam G, Krishna Mohan GV, Gul S, Ali S, Siddiqui A, et al. Effect of Discontinuation of Renin Angiotensin-System Inhibitors in Patients With Advanced Chronic Kidney Disease: A Meta-Analysis. Cureus 2023;15. https://doi.org/10.7759/cureus.37813. DOI: https://doi.org/10.7759/cureus.37813

Flythe JE, Assimon MM, Tugman MJ, Narendra JH, Singh SK, Jin W, et al. Efficacy, Safety, and Tolerability of Oral Furosemide Among Patients Receiving Hemodialysis: A Pilot Study. Kidney International Reports 2022;7:2186–95. https://doi.org/10.1016/j.ekir.2022.07.003. DOI: https://doi.org/10.1016/j.ekir.2022.07.003

Hendardi FAM, Kosnayani AS, Listyawardhani Y. Hubungan Asupan Protein, Asam Folat dan Zat Besi dengan Kadar Hemoglobin Post-Hemodialisis pada Pasien Penyakit Ginjal Kronis. Muhammadiyah Journal of Nutrition and Food Science (MJNF) 2024;5:65. https://doi.org/10.24853/mjnf.5.1.65-73. DOI: https://doi.org/10.24853/mjnf.5.1.65-73

Athish K, Nayak Rao S, Marimuthu VH, Krishna V, Arun A. Tenofovir-Associated Kidney Dysfunction and Bone Fracture: A Case Report and Literature Review. Cureus 2024;16:3–7. https://doi.org/10.7759/cureus.61562. DOI: https://doi.org/10.7759/cureus.61562