Anti-inflammatory Activity of Bay Leaf (Sygyzium polyanthum Wight.) Aqueous Extract in Male Wistar Rats Induced by 1% Carrageenan
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Fenny Hasanah, Nurul Hidayah (2018). Anti-inflammatory Activity of Bay Leaf (Sygyzium polyanthum Wight.) Aqueous Extract in Male Wistar Rats Induced by 1% Carrageenan. Journal of Pharmaceutical and Sciences, JPS Volume 1 Nomor 1 (2018). https://doi.org/10.36490/journal-jps.com.v1i1.3
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Abstract
Inflammation is a local reaction of an organism to an irritant or non-physiological state. Existing anti-inflammatory treatments have many side effects if used for a long time. Indonesian people have known and made bay leaves as anti-inflammatory drugs. The purpose of this study was to determine the antiinflammatory activity of bay leaf water extract (Sygyzium polyanthum Wight.) On the feet of male Wistar rats which were induced by carrageenan 1%. The research method used is experimental. The data obtained were analyzed by SPSS 20.0 ANOVA method at a confidence level of 95%. The results of the characteristics of the bay leaf simplicia showed that the water content was 6.6%, the water soluble extract content was 35%, the soluble extract content of ethanol was 21%. The antiinflammatory test results, observed by the percentage of inflammation in the induction group, had the highest percentage of inflammation compared to the other test groups at minute (T300). Whereas in the percentage of inflammation inhibition, all groups of test extracts have effectiveness that is comparable to the comparison group at (T300). EADS group 50 mg / kgbb is the best dose of extract as anti-inflammatory at (T300) where flavonoid compounds are thought to be responsible for decreasing the volume of inflammation in the legs of test animals.
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