Uji efektivitas sediaan sirup dari ekstrak etanol daun jambu biji merah (Psidium guajava Linn.) sebagai antipiretik terhadap mencit jantan
Statistik artikel
Data OJS dan sumber sitasiTayangan dan unduhan adalah aktivitas yang tercatat di OJS; pemrosesan statistik dapat tertunda. Tanda — berarti angka dari sumber tersebut belum tersedia. Cari di Google Scholar
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Cut Alfia Nafiza, Syilvi Rinda Sari, Minda Sari Lubis, Rafita Yuniarti (2026). Uji efektivitas sediaan sirup dari ekstrak etanol daun jambu biji merah (Psidium guajava Linn.) sebagai antipiretik terhadap mencit jantan. Journal of Pharmaceutical and Sciences, JPS Volume 9 Nomor 4 (2026). https://doi.org/10.36490/journal-jps.com.v9i4.2188
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Latar belakang: Daun jambu biji (Psidium guajava L.) mengandung metabolit sekunder yang berpotensi memiliki aktivitas antipiretik, tetapi bukti pada sediaan sirup masih terbatas. Tujuan: Mengevaluasi karakteristik fisik dan respons antipiretik ekstrak etanol serta sirup daun jambu biji pada mencit jantan dengan demam terinduksi pepton. Metode: Ekstraksi dilakukan dengan maserasi etanol 96%, kemudian ekstrak diformulasikan menjadi sirup berkadar 15,5%, 23,2%, dan 31%. Karakteristik fisik diamati selama empat minggu. Suhu rektal diukur sebelum induksi, satu jam sesudah induksi, serta setiap 30 menit sampai 120 menit setelah perlakuan pada lima kelompok (n = 5 per kelompok pada setiap kumpulan data ekstrak dan sirup). Hasil: Rendemen ekstrak mencapai 24,57%; pH sirup berkisar 6,04–6,84 dan rerata viskositas formula 29,98–59,26 cP selama pengamatan. Pada menit ke-120, suhu rata-rata kelompok ekstrak dengan dosis nominal 100, 150, dan 200 mg/kg BB berturut-turut 36,20; 36,00; dan 36,30 °C, sedangkan kontrol negatif 37,42 °C. Pada kelompok sirup, suhu akhir berturut-turut 36,62; 36,32; dan 36,26 °C dibandingkan 37,64 °C pada kontrol negatif. Perbedaan antarkelompok pada menit ke-120 bermakna secara statistik (p < 0,001; analisis varians satu arah). Kesimpulan: Ekstrak dan sirup menunjukkan respons antipiretik pada model hewan ini. Kelompok sirup dosis nominal 200 mg/kg BB memperlihatkan penurunan suhu rata-rata terbesar pada menit ke-120. Verifikasi kesetaraan dosis dan evaluasi stabilitas lanjutan masih diperlukan.
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