Prevalence and risk factors for potential drug interactions in geriatric patients with type 2 diabetes mellitus (This study was conducted at the Haji Regional General Hospital, East Java Province)
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Asri Wido Mukti, Ira Purbosari, Nadya Ambarwati (2026). Prevalence and risk factors for potential drug interactions in geriatric patients with type 2 diabetes mellitus. Journal of Pharmaceutical and Sciences, JPS Volume 9 Nomor 4 (2026). https://doi.org/10.36490/journal-jps.com.v9i4.1771
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Abstrak
Pasien geriatri dengan diabetes melitus tipe 2 (DMT2) memiliki risiko tinggi mengalami interaksi obat akibat polifarmasi dan penurunan fungsi fisiologis terkait usia. Interaksi obat dapat meningkatkan risiko hipoglikemia, hiperglikemia, serta komplikasi kardiovaskular. Tujuan penelitian ini adalah untuk menganalisis prevalensi, tingkat keparahan, mekanisme, dan faktor risiko potensial interaksi obat antidiabetes dengan terapi lain pada pasien geriatri DMT2. Metode penelitian dilakukan secara observasional dengan mengumpulkan rekam medis secara retrospektif periode Januari - Desember 2023 di RSUD Haji Provinsi Jawa Timur. Hasil penelitian didapatkan total 94 pasien dengan Interaksi dengan tingkat keparahan mayor sebanyak (19,0%) pada obat spironolactone dengan candesartan, interaksi dengan tingkat keparahan moderate sebanyak (81.0%) pada obat glimepiride dengan metformin. Sedangkan interaksi berdasarkan mekanisme farmakokinetik (66.0%) pada obat glimepiride dengan metformin. Berdasarkan mekanisme farmakodinamik (34.0%) pada obat glimepiride dengan insulin degludec.
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Referensi
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