OTOTOKSISITAS PADA PASIEN TUBERKULOSIS RESISTEN OBAT: SCOPING REVIEW PADA STUDI DI INDONESIA
Statistik artikel
Data OJS dan sumber sitasiTayangan dan unduhan adalah aktivitas yang tercatat di OJS; pemrosesan statistik dapat tertunda. Tanda — berarti angka dari sumber tersebut belum tersedia. Cari di Google Scholar
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Oki Nugraha Putra, Affan Yuniar N.H., Fariz Hidayat, I.G.E. Sagitha (2022). OTOTOKSISITAS PADA PASIEN TUBERKULOSIS RESISTEN OBAT: SCOPING REVIEW PADA STUDI DI INDONESIA. Journal of Pharmaceutical and Sciences, Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022). https://doi.org/10.36490/journal-jps.com.v5i1.71
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Abstrak
Variasi yang luas dalam ototoksisitas atau gangguan pendengaran akibat obat antituberkulosis injeksi pada pasien dengan multidrug-resistant tuberculosis (MDR-TB) telah dilaporkan secara global dan di Indonesia. Scoping review ini mengulas ototoksisitas obat antituberkulosis injeksi lini kedua pada pasien MDR-TB di Indonesia. Tinjauan ini dilakukan menggunakan PRISMA extension for scoping review (PRISMA-ScR). Database Google Scholar dan PubMed digunakan untuk mencari artikel tentang MDR-TB pada penelitian di Indonesia. Tujuh penelitian diidentifikasi berdasarkan kriteria inklusi yang melaporkan kanamisin dan kapreomisin sebagai tatalaksana MDR-TB. Ototoksisitas ditemukan pada 39,3% (116/295) pasien TB-MDR. Ototoksisitas diamati pada kanamisin, 38,7% (105/271 pasien); kapreomisin, 36,8% (7/19 pasien); dan kanamisin ditambah kapreomisin, 80% (4/5 pasien). Hanya satu penelitian yang melaporkan faktor risiko ototoksisitas pada pasien TB-MDR. Ototoksisitas secara signifikan terkait dengan usia yang lebih tua dan lamanya terapi kanamisin berkorelasi dengan gangguan pendengaran. Review ini mengidentifikasi prevalensi tinggi ototoksisitas pada pasien MDR-TB Indonesia yang diobati dengan obat injeksi lini kedua. Upaya sangat diperlukan untuk mengembangkan pedoman untuk memantau ototoksisitas, meningkatkan kesadaran apoteker dan dokter, dan mendidik pasien untuk melaporkan gejala gangguan pendengaran sebagai tanda ototoksisitas.
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Referensi
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